TARTARIC ACID

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C4H6O6
Molecular Weight	150.0868
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O

InChI

InChIKey=FEWJPZIEWOKRBE-JCYAYHJZSA-N

InChI=1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C4H6O6
Molecular Weight	150.0868
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://link.springer.com/article/10.1007/s12045-007-0005-6 | http://www.foodchemadditives.com/products/L-Tartaric-Acid

Tartaric acid is found in many plants such as grapes, tamarinds, pineapples, mulberries and so on. Wine lees (called mud in the US), the sediment collected during the fermentation of grapes, contains potassium bitartrate (potassium hydrogen tartrate) as its major component. L-(+)-tartaric acid is an enantiomer of tartaric acid. Twenty five years before the tetrahedral structure for carbon was proposed in 1874 to explain the optical activity and other properties of organic compounds, Louis Pasteur discovered the existence of enantiomerism in tartaric acid. L-(+)-tartaric acid is widely used in food and beverage as acidity regulator with E number E334.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
skin cleasing 9 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a33a11b2-926e-43bb-8775-d94b730d2c78	Inactive ingredient		Approved 8360	CLEARASIL DAILY CLEAR CLEAR SKIN Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-059382	http://www.3bsc.com/index/pro_info.php?id=98203
AK Scientific, Inc. (AKSCI)	7165AF	http://www.aksci.com/item_detail.php?cat=7165AF
Acadechem	ACDS-067423	http://www.acadechemical.com/product/142122
Alfa Chemistry	AP6106247-A	https://reagents.alfa-chemistry.com/product/sodium-tartrate-dihydrate-cas-6106-24-7-14010.html
Alfa Chemistry	AP6106247-B	https://reagents.alfa-chemistry.com/product/sodium-tartrate-dihydrate-cas-6106-24-7-14011.html
Ambinter	Amb22348226	http://www.ambinter.com/reference/22348226
Anward	ANW-33667	http://www.anward.com/pro_result/23235
Aurora Fine Chemicals LLC	A14.518.215	http://online.aurorafinechemicals.com/info?ID=A14.518.215
Avantor Inc	101225-558	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101225-558
Avantor Inc	101226-150	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101226-150
BOC Sciences	6106-24-7	https://www.bocsci.com/disodium-tartrate-dihydrate-cas-6106-24-7-item-95530.html
Chemspace	CSSB00102632354	https://chem-space.com/CSSB00102632354
Combi-Blocks	QE-8461	http://www.combi-blocks.com/cgi-bin/find.cgi?QE-8461
Fisher Chemical	AL2770100	https://www.fishersci.com/shop/products/aqualine-sodium-tartrate-dihydrate-water-standard-fisher-chemical/AL2770100
Fisher Chemical	S433100	https://www.fishersci.com/shop/products/sodium-l-tartrate-dihydrate-crystalline-certified-fisher-chemical-2/p-192917
Fisher Chemical	S433500	https://www.fishersci.com/shop/products/sodium-l-tartrate-dihydrate-crystalline-certified-fisher-chemical-2/p-192917
Glentham Life Sciences	GK1687	http://www.glentham.com/products/product/GK1687/
MolPort	MolPort-003-928-192	https://www.molport.com/shop/molecule-link/MolPort-003-928-192
Oakwood	104960	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=196368&ExtHyperLink=1
Oakwood	94747	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=79921&ExtHyperLink=1
Sigma-Aldrich	28-4380_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/284380?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	228729_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/228729?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	71995_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/71995?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	71994_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/71994?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1614909_USP	https://www.sigmaaldrich.com/catalog/product/usp/1614909?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S051766	http://www.sinfoobiotech.com/product/1055164
abcr GmbH	AB118837	http://www.abcr.de/shop/en/AB118837
abcr GmbH	AB207455	http://www.abcr.de/shop/en/AB207455
iChemical	EBD16533	http://www.ichemical.com/chemicals/cas-6106-24-7

PubMed

Title	Date	PubMed
Cell-surface recognition of biotinylated membrane proteins requires very long spacer arms: an example from glucose-transporter probes.	2001 Jan 8	11828427
[Acid phosphatase, ACP (EC 3.1.3.2)].	2001 Nov	11797369
Preformulation studies for an ultrashort-acting neuromuscular blocking agent GW280430A. I. Buffer and cosolvent effects on the solution stability.	2002	11926357
The MRP1-mediated effluxes of arsenic and antimony do not require arsenic-glutathione and antimony-glutathione complex formation.	2002 Apr	12018890
New materials for ESR dosimetry.	2002 Apr	11993477
Acid phosphatases.	2002 Apr	11950951
The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor.	2002 Apr	11937054
Initial stages of cell-matrix adhesion can be mediated and modulated by cell-surface hyaluronan.	2002 Apr	11916844
Chiral versus racemic building blocks in supramolecular chemistry: tartrate salts of organic diamines.	2002 Apr	11910165
Stereoselective synthesis of myo-inositol via ring-closing metathesis: a building block for glycosylphosphatidylinositol (GPI) anchor synthesis.	2002 Apr 18	11950362
Towards atomic resolution with crystals grown in gel: the case of thaumatin seen at room temperature.	2002 Aug 1	12112683
Thermophysical properties of pharmaceutically compatible buffers at sub-zero temperatures: implications for freeze-drying.	2002 Feb	11883647
Retention of anions on silica-based metalloporphyrin stationary phases.	2002 Feb	11874117
Ergotamine-induced anorectal strictures: report of five cases.	2002 Feb	11852344
Diaquabis[mu-(R,R)-tartrato-kappa4O1,O2:O3,O4]dinickel(II) trihydrate.	2002 Feb	11828105
The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.	2002 Feb	11818452
Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells.	2002 Feb	11796394
Screening method for inherited disorders of purine and pyrimidine metabolism by capillary electrophoresis with reversed electroosmotic flow.	2002 Feb 15	11885862
Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade.	2002 Jan	11899358
Therapy and disease concepts: the history (and future?) of antimony in cancer.	2002 Jan	11892514
Some comparative aspects of the pharmacokinetics of tylosin in buffaloes and cattle.	2002 Jan	11860087
Anaerobaculum mobile sp. nov., a novel anaerobic, moderately thermophilic, peptide-fermenting bacterium that uses crotonate as an electron acceptor, and emended description of the genus Anaerobaculum.	2002 Jan	11837298
From local adsorption stresses to chiral surfaces: (R,R)-tartaric acid on Ni(110).	2002 Jan 23	11792223
Effect of antibiotics on in vitro and in vivo avian cartilage degradation.	2002 Jan-Mar	11922351
In vitro antibiotic susceptibility of field isolates of Mycoplasma synoviae in Argentina.	2002 Jan-Mar	11922338
A simple spectrophotometric method for the determination of copper in industrial, environmental, biological and soil samples using 2,5-dimercapto-1,3,4-thiadiazole.	2002 Jul	12137377
High frequency of phenotypic deviations in Physcomitrella patens plants transformed with a gene-disruption library.	2002 Jul 18	12123528
Boronic acid receptors for alpha-hydroxycarboxylates: high affinity of Shinkai's glucose receptor for tartrate.	2002 Jul 26	12126445
Engineering the substrate specificity of D-amino-acid oxidase.	2002 Jul 26	12021281
Improving the labeling of S-acetyl NHS-MAG(3)-conjugated morpholino oligomers.	2002 Jul-Aug	12121147
Effects of cyclic pressure on bone marrow cell cultures.	2002 Jun	12071266
Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice.	2002 Jun	12054176
Stereoselective radical reactions of some tartaric and glyceric acid derivatives.	2002 Jun 13	12049511
The separation of racemic crystals into enantiomers by chiral block copolymers.	2002 Jun 3	12180321
Determination of the side-products formed during the nitroxide-mediated bleach oxidation of glucose to glucaric acid.	2002 Jun 5	12039549
Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo.	2002 Jun 7	12052261
Gender- and age-related differences in osteoclast formation from circulating precursors.	2002 Mar	11874715
Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice.	2002 Mar 1	11855834
Consumption of an omega-3 fatty acids product, INCELL AAFA, reduced side-effects of CPT-11 (irinotecan) in mice.	2002 Mar 18	11953833
Release of an acid phosphatase activity during lily pollen tube growth involves components of the secretory pathway.	2002 May	12099218
Use of disposable GRC electrodes for the detection of phenol and chlorophenols in liquid chromatography.	2002 May	12036123
Crystallization and preliminary X-ray crystallographic analysis of UDP-N-acetylglucosamine acyltransferase from Helicobacter pylori.	2002 May	11976505
Potassium antimonyl tartrate induces reactive oxygen species-related apoptosis in human myeloid leukemic HL60 cells.	2002 May	11956606
Synovial macrophage-osteoclast differentiation in inflammatory arthritis.	2002 Oct	12228163
Ectonucleotide diphosphohydrolase activity in Crithidia deanei.	2002 Oct	12209331
Formation of methylantimony species by an aerobic prokaryote: Flavobacterium sp.	2002 Oct	12209260
Effects of sigma(1) receptor ligand MS-377 on D(2) antagonists-induced behaviors.	2002 Oct	12151023
Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5.	2002 Oct 15	12119043
Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator.	2002 Oct 25	12171919
Symmetric and helical growth of polyacetylene fibers over a single copper crystal derived from copper tartrate decomposition.	2002 Sep 5	12201732

Patents

Sample Use Guides

In Vivo Use Guide

L-(+)-tartaric acid as a food additive. Acceptable Daily Intake: 0-30 mg/kg

Route of Administration: Oral

In Vitro Use Guide

After incubation in medium containing 50 mM L(+)-tartaric acid, osteoclasts and chondroclasts were heavily stained with reaction product.

Substance Class	Chemical Created by `admin` on `Wed Jul 05 22:31:22 UTC 2023` Edited by `admin` on `Wed Jul 05 22:31:22 UTC 2023`
Record UNII	W4888I119H
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TARTARIC ACID

Official Name

English

BUTANEDIOIC ACID, 2,3-DIHYDROXY-, (R-(R*,R*))-

Common Name

English

INS-334

Code

English

E-334

Code

English

TARTARIC ACID [JAN]

Common Name

English

FEMA NO. 3044

Code

English

L-TARTARIC ACID [MI]

Common Name

English

TARTARICUM ACIDUM

Common Name

English

TARTARIC ACID [FCC]

Common Name

English

TARTARIC ACID [ORANGE BOOK]

Common Name

English

(2R,3R)-2,3-DIHYDROXYBUTANEDIOIC ACID

Systematic Name

English

L-2,3-DIHYDROXYBUTANEDIOIC ACID

Common Name

English

THREARIC ACID

Common Name

English

L-TARTARIC ACID

Systematic Name

English

TARTRATE

Common Name

English

NSC-62778

Code

English

TARTARIC ACID [EP MONOGRAPH]

Common Name

English

INS NO.334

Code

English

NATURAL TARTARIC ACID

Common Name

English

TARTARIC ACID [USP-RS]

Common Name

English

L-2,3-DIHYDROXYSUCCINIC ACID

Common Name

English

TARTARIC ACID [II]

Common Name

English

TARTARIC ACID, L-

Common Name

English

Tartaric acid [WHO-DD]

Common Name

English

E 334

Code

English

TARTARIC ACID (L(+)-)

Common Name

English

TARTARIC ACID [INCI]

Common Name

English

L-(+)-TARTARIC ACID

Systematic Name

English

TARTARIC ACID COMPONENT OF BAROS

Common Name

English

TARTARIC ACID [MART.]

Common Name

English

(+)-TARTARIC ACID

Systematic Name

English

BAROS COMPONENT TARTARIC ACID

Common Name

English

TARTARIC ACID [VANDF]

Common Name

English

TARTARICUM ACIDUM [HPUS]

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

INS-334