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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H21N3S.C4H6O6
Molecular Weight 497.563
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIOMERGINE TARTRATE

SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@@]12CC3=CNC4=C3C(=CC=C4)C1=C[C@@H](CSC5=CC=CC=N5)CN2C

InChI

InChIKey=DGGLBKGGUQAMKR-VAPABEGGSA-N
InChI=1S/C21H21N3S.C4H6O6/c1-24-12-14(13-25-20-7-2-3-8-22-20)9-17-16-5-4-6-18-21(16)15(11-23-18)10-19(17)24;5-1(3(7)8)2(6)4(9)10/h2-9,11,14,19,23H,10,12-13H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,19-;1-,2-/m11/s1

HIDE SMILES / InChI

Molecular Formula C4H6O6
Molecular Weight 150.0868
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula C21H21N3S
Molecular Weight 347.477
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Tiomergine is an ergot alkaloid derivative. It is the agonist of the postulated presynaptic dopamine receptor. Tiomergine is the antiparkinsonian agent. Tiomergine modified brain glucose metabolism in a way similar to the neuroleptics but different from postsynaptic agonists. It was ineffective in the treatment of tardive dyskinesia.

Approval Year

PubMed

PubMed

TitleDatePubMed
Treatment of dyskinetic and dystonic disorders with CF 25-397: clinical and pharmacological aspects.
1980
Bromocriptine and CF 25-397 in the treatment of tardive dyskinesia.
1980 Apr
Presynaptic dopaminergic agonists modify brain glucose metabolism in a way similar to the neuroleptics.
1984 Sep 7
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 15:24:56 UTC 2023
Edited
by admin
on Fri Dec 15 15:24:56 UTC 2023
Record UNII
W36P44AVBI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TIOMERGINE TARTRATE
Common Name English
CF-25-397 TARTRATE
Code English
ERGOLINE, 9,10-DIDEHYDRO-6-METHYL-8-((2-PYRIDINYLTHIO)METHYL)-, (8.BETA.)-, (R-(R*,R*))-2,3-DIHYDROXYBUTANEDIOATE
Systematic Name English
ERGOLINE, 9,10-DIDEHYDRO-6-METHYL-8-((2-PYRIDINYLTHIO)METHYL)-, (8.BETA.)-, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE (1:1)
Systematic Name English
ERGOLINE, 9,10-DIDEHYDRO-6-METHYL-8-((2-PYRIDINYLTHIO)METHYL)-, (8.BETA.)-, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE
Systematic Name English
Code System Code Type Description
CAS
58078-87-8
Created by admin on Fri Dec 15 15:24:56 UTC 2023 , Edited by admin on Fri Dec 15 15:24:56 UTC 2023
NON-SPECIFIC STOICHIOMETRY
PUBCHEM
72710770
Created by admin on Fri Dec 15 15:24:56 UTC 2023 , Edited by admin on Fri Dec 15 15:24:56 UTC 2023
PRIMARY
CAS
65530-40-7
Created by admin on Fri Dec 15 15:24:56 UTC 2023 , Edited by admin on Fri Dec 15 15:24:56 UTC 2023
PRIMARY
FDA UNII
W36P44AVBI
Created by admin on Fri Dec 15 15:24:56 UTC 2023 , Edited by admin on Fri Dec 15 15:24:56 UTC 2023
PRIMARY
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ACTIVE MOIETY