TIOMERGINE TARTRATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H21N3S.C4H6O6
Molecular Weight	497.563
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@@]12CC3=CNC4=C3C(=CC=C4)C1=C[C@@H](CSC5=CC=CC=N5)CN2C

InChI

InChIKey=DGGLBKGGUQAMKR-VAPABEGGSA-N

InChI=1S/C21H21N3S.C4H6O6/c1-24-12-14(13-25-20-7-2-3-8-22-20)9-17-16-5-4-6-18-21(16)15(11-23-18)10-19(17)24;5-1(3(7)8)2(6)4(9)10/h2-9,11,14,19,23H,10,12-13H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,19-;1-,2-/m11/s1

HIDE SMILES / InChI

Molecular Formula	C4H6O6
Molecular Weight	150.0868
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C21H21N3S
Molecular Weight	347.477
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6149502 | https://www.ncbi.nlm.nih.gov/pubmed/6102461 | https://apps.who.int/iris/bitstream/handle/10665/68742/WHO_EDM_QSM_2004.5.pdf | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 1206, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Tiomergine is an ergot alkaloid derivative. It is the agonist of the postulated presynaptic dopamine receptor. Tiomergine is the antiparkinsonian agent. Tiomergine modified brain glucose metabolism in a way similar to the neuroleptics but different from postsynaptic agonists. It was ineffective in the treatment of tardive dyskinesia.

Approval Year

PubMed

Title	Date	PubMed
Treatment of dyskinetic and dystonic disorders with CF 25-397: clinical and pharmacological aspects.	1980	6446848
Bromocriptine and CF 25-397 in the treatment of tardive dyskinesia.	1980 Apr	6102461
Presynaptic dopaminergic agonists modify brain glucose metabolism in a way similar to the neuroleptics.	1984 Sep 7	6149502

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:24:56 GMT 2023` Edited by `admin` on `Fri Dec 15 15:24:56 GMT 2023`
Record UNII	W36P44AVBI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TIOMERGINE TARTRATE

Common Name

English

CF-25-397 TARTRATE

Code

English

ERGOLINE, 9,10-DIDEHYDRO-6-METHYL-8-((2-PYRIDINYLTHIO)METHYL)-, (8.BETA.)-, (R-(R*,R*))-2,3-DIHYDROXYBUTANEDIOATE

Systematic Name

English

ERGOLINE, 9,10-DIDEHYDRO-6-METHYL-8-((2-PYRIDINYLTHIO)METHYL)-, (8.BETA.)-, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE (1:1)

Systematic Name

English

ERGOLINE, 9,10-DIDEHYDRO-6-METHYL-8-((2-PYRIDINYLTHIO)METHYL)-, (8.BETA.)-, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE

Systematic Name

English

Code System Code Type Description

CAS

58078-87-8

Created by admin on Fri Dec 15 15:24:56 GMT 2023 , Edited by admin on Fri Dec 15 15:24:56 GMT 2023

NON-SPECIFIC STOICHIOMETRY

PUBCHEM

72710770

Created by admin on Fri Dec 15 15:24:56 GMT 2023 , Edited by admin on Fri Dec 15 15:24:56 GMT 2023

PRIMARY

CAS

65530-40-7

Created by admin on Fri Dec 15 15:24:56 GMT 2023 , Edited by admin on Fri Dec 15 15:24:56 GMT 2023

PRIMARY

FDA UNII

W36P44AVBI

Created by admin on Fri Dec 15 15:24:56 GMT 2023 , Edited by admin on Fri Dec 15 15:24:56 GMT 2023

PRIMARY

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