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Details

Stereochemistry ABSOLUTE
Molecular Formula C27H31I2NO5.C4H6O6
Molecular Weight 853.4345
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BUDIODARONE TARTRATE

SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@H](C)OC(=O)CC1=C(C(=O)C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)C3=C(O1)C=CC=C3

InChI

InChIKey=CAMFTHAPYYLIIG-YRSVLNEHSA-N
InChI=1S/C27H31I2NO5.C4H6O6/c1-5-17(4)34-24(31)16-23-25(19-10-8-9-11-22(19)35-23)26(32)18-14-20(28)27(21(29)15-18)33-13-12-30(6-2)7-3;5-1(3(7)8)2(6)4(9)10/h8-11,14-15,17H,5-7,12-13,16H2,1-4H3;1-2,5-6H,(H,7,8)(H,9,10)/t17-;1-,2-/m01/s1

HIDE SMILES / InChI

Molecular Formula C27H31I2NO5
Molecular Weight 703.3477
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula C4H6O6
Molecular Weight 150.0868
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Budiodarone is a chemical analog of amiodarone with mixed ion channel electrophysiological activity. Budiodarone was developed to capitalize on the proven efficacy of amiodarone and to avoid its side effects. Budiodarone has a short plasma half-life (7 h) and a lower volume of distribution (13 L/kg). It is cleared from the body in 48 h. Like amiodarone, Budiodarone has balanced, multiple cardiac ion channel inhibiting activity, giving it properties of all four Vaughan Williams antiarrhythmic drug classes. Budiodarone, unlike amiodarone, undergoes rapid metabolism by plasma and tissue esterases. In clinical trials, Budiodarone effectively reduces the number and duration of atrial tachycardia/atrial fibrillation episodes.

Approval Year

PubMed

PubMed

TitleDatePubMed
A randomized trial of budiodarone in paroxysmal atrial fibrillation.
2012 Jun
Patents

Patents

Sample Use Guides

400 and 600 mg BID
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:22:23 GMT 2023
Edited
by admin
on Fri Dec 15 16:22:23 GMT 2023
Record UNII
3HV5H0W9GM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BUDIODARONE TARTRATE
USAN  
USAN  
Official Name English
(1S)-1-Methylpropyl 2-(3-{4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl}benzofuran-2-yl)acetate, hydrogen (2R,3R)-2,3-dihydroxybutanedioate
Common Name English
ATI-2042 TARTRATE
Code English
2-BENZOFURANACETIC ACID, 3-(4-(2-(DIETHYLAMINO)ETHOXY)-3,5-DIIODOBENZOYL)-, (1S)-1-METHYLPROPYL ESTER, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE (1:1)
Common Name English
BUDIODARONE TARTRATE [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47793
Created by admin on Fri Dec 15 16:22:23 GMT 2023 , Edited by admin on Fri Dec 15 16:22:23 GMT 2023
Code System Code Type Description
CAS
478941-93-4
Created by admin on Fri Dec 15 16:22:23 GMT 2023 , Edited by admin on Fri Dec 15 16:22:23 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105631
Created by admin on Fri Dec 15 16:22:23 GMT 2023 , Edited by admin on Fri Dec 15 16:22:23 GMT 2023
PRIMARY
DRUG BANK
DBSALT002596
Created by admin on Fri Dec 15 16:22:23 GMT 2023 , Edited by admin on Fri Dec 15 16:22:23 GMT 2023
PRIMARY
USAN
UU-118
Created by admin on Fri Dec 15 16:22:23 GMT 2023 , Edited by admin on Fri Dec 15 16:22:23 GMT 2023
PRIMARY
SMS_ID
300000044570
Created by admin on Fri Dec 15 16:22:23 GMT 2023 , Edited by admin on Fri Dec 15 16:22:23 GMT 2023
PRIMARY
NCI_THESAURUS
C83564
Created by admin on Fri Dec 15 16:22:23 GMT 2023 , Edited by admin on Fri Dec 15 16:22:23 GMT 2023
PRIMARY
FDA UNII
3HV5H0W9GM
Created by admin on Fri Dec 15 16:22:23 GMT 2023 , Edited by admin on Fri Dec 15 16:22:23 GMT 2023
PRIMARY
PUBCHEM
25227360
Created by admin on Fri Dec 15 16:22:23 GMT 2023 , Edited by admin on Fri Dec 15 16:22:23 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY