SOLYPERTINE TARTRATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H25N3O3.C4H6O6
Molecular Weight	529.539
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O.COC1=C(C=CC=C1)N2CCN(CCC3=CNC4=C3C=C5OCOC5=C4)CC2

InChI

InChIKey=FDYHSJCNTRLQCR-LREBCSMRSA-N

InChI=1S/C22H25N3O3.C4H6O6/c1-26-20-5-3-2-4-19(20)25-10-8-24(9-11-25)7-6-16-14-23-18-13-22-21(12-17(16)18)27-15-28-22;5-1(3(7)8)2(6)4(9)10/h2-5,12-14,23H,6-11,15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1

HIDE SMILES / InChI

Molecular Formula	C22H25N3O3
Molecular Weight	379.4522
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H6O6
Molecular Weight	150.0868
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://books.google.ca/books?id=0vXTBwAAQBAJ&pg=PA1105&lpg=PA1105&dq=SOLYPERTINE retrieved from The Dictionary of Drugs: Chemical Data. Chemical Data, Structures and Bibliographies. Editors: Elks, J. (Ed.), p.1105 | https://www.ncbi.nlm.nih.gov/pubmed/5919502

Solypertine (WIN-18413-2) is an antiadrenergic drug. Solypertine selectively blocked the conditioned avoidance response in rats. Solypertine potentiated hexobarbitone sleeping time, caused hypothermia and afforded protection from amphetamine toxicity inaggregated mice.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Pyscho-sedative properties of three indolyl-ethyl-piperazine derivatives.	1966 Jan	5919502

Patents

Sample Use Guides

In Vivo Use Guide

Mice: LD50 = 81.5 mg/kg. Solypertine (WIN-18413-2) in doses of 4 and 8 mg/kg, caused behavioural depression and apathy in the cats.

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:11:46 UTC 2023` Edited by `admin` on `Fri Dec 15 15:11:46 UTC 2023`
Record UNII	LGH2D06D4K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SOLYPERTINE TARTRATE

Official Name

English

WIN-18413-2

Code

English

5H-1,3-DIOXOLO(4,5-F)INDOLE, 7-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-, (R-(R*,R*))-2,3-DIHYDROXYBUTANEDIOATE (1:1)

Common Name

English

7-[2-[4-(O-Methoxyphenyl)-1-piperazinyl]ethyl]-5H-1,3-dioxolo-[4,5-f]-indole tartrate (1:1)

Common Name

English

WIN 18,413-2

Code

English

SOLYPERTINE TARTRATE [USAN]

Common Name

English

NSC-107432

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29710