SOLYPERTINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H25N3O3
Molecular Weight	379.4522
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C(C=CC=C1)N2CCN(CCC3=CNC4=CC5=C(OCO5)C=C34)CC2

InChI

InChIKey=GIWODWVYEOAGQV-UHFFFAOYSA-N

InChI=1S/C22H25N3O3/c1-26-20-5-3-2-4-19(20)25-10-8-24(9-11-25)7-6-16-14-23-18-13-22-21(12-17(16)18)27-15-28-22/h2-5,12-14,23H,6-11,15H2,1H3

HIDE SMILES / InChI

Molecular Formula	C22H25N3O3
Molecular Weight	379.4522
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://books.google.ca/books?id=0vXTBwAAQBAJ&pg=PA1105&lpg=PA1105&dq=SOLYPERTINE retrieved from The Dictionary of Drugs: Chemical Data. Chemical Data, Structures and Bibliographies. Editors: Elks, J. (Ed.), p.1105 | https://www.ncbi.nlm.nih.gov/pubmed/5919502

Solypertine (WIN-18413-2) is an antiadrenergic drug. Solypertine selectively blocked the conditioned avoidance response in rats. Solypertine potentiated hexobarbitone sleeping time, caused hypothermia and afforded protection from amphetamine toxicity inaggregated mice.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Pyscho-sedative properties of three indolyl-ethyl-piperazine derivatives.	1966 Jan	5919502

Patents

Sample Use Guides

In Vivo Use Guide

Mice: LD50 = 81.5 mg/kg. Solypertine (WIN-18413-2) in doses of 4 and 8 mg/kg, caused behavioural depression and apathy in the cats.

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:55:27 GMT 2023` Edited by `admin` on `Fri Dec 15 18:55:27 GMT 2023`
Record UNII	9BUF6DCO0C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SOLYPERTINE

Official Name

English

solypertine [INN]

Common Name

English

5H-1,3-DIOXOLO(4,5-F)INDOLE, 7-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-

Systematic Name

English

7-(2-(4-(O-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-5H-1,3-DIOXOLO(4,5-F)INDOLE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66883