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Details

Stereochemistry ACHIRAL
Molecular Formula C22H25N3O3
Molecular Weight 379.4522
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SOLYPERTINE

SMILES

COC1=C(C=CC=C1)N2CCN(CCC3=CNC4=CC5=C(OCO5)C=C34)CC2

InChI

InChIKey=GIWODWVYEOAGQV-UHFFFAOYSA-N
InChI=1S/C22H25N3O3/c1-26-20-5-3-2-4-19(20)25-10-8-24(9-11-25)7-6-16-14-23-18-13-22-21(12-17(16)18)27-15-28-22/h2-5,12-14,23H,6-11,15H2,1H3

HIDE SMILES / InChI

Molecular Formula C22H25N3O3
Molecular Weight 379.4522
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Solypertine (WIN-18413-2) is an antiadrenergic drug. Solypertine selectively blocked the conditioned avoidance response in rats. Solypertine potentiated hexobarbitone sleeping time, caused hypothermia and afforded protection from amphetamine toxicity inaggregated mice.

CNS Activity

Curator's Comment: Solypertine selectively blocked the conditioned avoidance response in rats. Solypertine potentiated hexobarbitone sleeping time, caused hypothermia and afforded protection from amphetamine toxicity inaggregated mice.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

Mice: LD50 = 81.5 mg/kg. Solypertine (WIN-18413-2) in doses of 4 and 8 mg/kg, caused behavioural depression and apathy in the cats.
Route of Administration: Intraperitoneal
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:55:27 GMT 2023
Edited
by admin
on Fri Dec 15 18:55:27 GMT 2023
Record UNII
9BUF6DCO0C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SOLYPERTINE
INN  
INN  
Official Name English
solypertine [INN]
Common Name English
5H-1,3-DIOXOLO(4,5-F)INDOLE, 7-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-
Systematic Name English
7-(2-(4-(O-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-5H-1,3-DIOXOLO(4,5-F)INDOLE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66883
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
NCI_THESAURUS C29710
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
Code System Code Type Description
FDA UNII
9BUF6DCO0C
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
PUBCHEM
20517
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
EPA CompTox
DTXSID50196189
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
SMS_ID
100000084044
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
EVMPD
SUB10577MIG
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
ChEMBL
CHEMBL1739674
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
CAS
4448-96-8
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
NCI_THESAURUS
C152390
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
INN
1327
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY