PRAJMALIUM BITARTRATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H33N2O2.C4H5O6
Molecular Weight	518.5992
Optical Activity	UNSPECIFIED
Defined Stereocenters	12 / 12
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H]([C@@H](O)C([O-])=O)C(O)=O.[H][C@@]12N(C)C3=C(C=CC=C3)[C@]14C[C@H]5[C@@H]([C@H]4O)[C@@]6([H])C[C@]2([H])[N@+]5(CCC)[C@H](O)[C@H]6CC

InChI

InChIKey=VZAUGYDMVQSQAO-VOTNWUEESA-M

InChI=1S/C23H33N2O2.C4H6O6/c1-4-10-25-17-11-14(13(5-2)22(25)27)19-18(25)12-23(21(19)26)15-8-6-7-9-16(15)24(3)20(17)23;5-1(3(7)8)2(6)4(9)10/h6-9,13-14,17-22,26-27H,4-5,10-12H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/q+1;/p-1/t13-,14-,17-,18-,19-,20-,21+,22+,23+,25-;1-,2-/m01/s1

HIDE SMILES / InChI

Molecular Formula	C23H33N2O2
Molecular Weight	369.5203
Charge	1
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	8 / 10
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C4H5O6
Molecular Weight	149.0789
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1694924 | https://www.ncbi.nlm.nih.gov/pubmed/6723753 | https://www.ncbi.nlm.nih.gov/pubmed/4029242

Neo-Gilurythmal (or prajmaline), an antiarrhythmic agent, which is used to treat angina pectoris, Wolff–Parkinson–White Syndrome and coronary artery disease. Neo-Gilurythmal found to be effective even in the case where other previously used antiarrhythmics were ineffective.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
sodium channel complex 2 Target ID: GO:0034706 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2422563\|https://www.ncbi.nlm.nih.gov/pubmed/1886140\|https://www.ncbi.nlm.nih.gov/pubmed/2410054\|https://www.ncbi.nlm.nih.gov/pubmed/6249418	Blocker 537

PubMed

Title	Date	PubMed
[Efficacy of prajmaline (Neo-Gilurytmal) objectifiable by means of a test].	1983 May 5	6190722
Differential analysis of the frequency-dependent effects of class 1 antiarrhythmic drugs according to periodical ligand binding: implications for antiarrhythmic and proarrhythmic efficacy.	1990 Jun	1694924
The structure of the ring-opened N beta-propyl-ajmaline (Neo-Gilurytmal) at physiological pH is obviously responsible for its better absorption and bioavailability when compared with ajmaline (Gilurytmal).	2000 Jul	10944783

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:48:42 GMT 2023` Edited by `admin` on `Fri Dec 15 15:48:42 GMT 2023`
Record UNII	H671L9190Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PRAJMALIUM BITARTRATE

Official Name

English

NEO-GILURYTMAL

Common Name

English

PRAJMALINE HYDROGEN TARTRATE

Common Name

English

PRAJMALINE HYDROGEN TARTRATE [MI]

Common Name

English

NEO GILURYTHMAL

Brand Name

English

PRAJMALIUM BITARTRATE [MART.]

Common Name

English

AJMALANIUM, 17,21-DIHYDROXY-4-PROPYL-, (17R,21.ALPHA.)-, SALT WITH(2R,3R)-2,3-DIHYDROXYBUTANEDIOIC ACID (1:1)

Common Name

English

Prajmalium bitartrate [WHO-DD]

Common Name

English

NPA-P

Code

English

N-PROPYLAJMALINE BITARTRATE

Common Name

English

prajmalium bitartrate [INN]

Common Name

English

AJMALANIUM, 17,21-DIHYDROXY-4-PROPYL-, (17R,21.ALPHA.)-, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE (1:1)

Common Name

English

N-PROPYLAJMALINE HYDROGEN TARTRATE

Common Name

English

NPAP

Code

English

PRAJMALIUM BITARTRATE [JAN]

Common Name

English

PRAJMALINE BITARTRATE

Common Name

English

GT-1012

Code

English

BUTANEDIOIC ACID, 2,3-DIHYDROXY- (2R,3R)-, ION(1-), (17R,21.ALPHA.)-17,21-DIHYDROXY-4-PROPYLAJMALANIUM

Common Name

English

N-PROPYLAJMALINIUM TARTRATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793