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Details

Stereochemistry ABSOLUTE
Molecular Formula C4H5O6.Na
Molecular Weight 172.0687
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM BITARTRATE

SMILES

[Na+].O[C@H]([C@@H](O)C([O-])=O)C(O)=O

InChI

InChIKey=NKAAEMMYHLFEFN-ZVGUSBNCSA-M
InChI=1S/C4H6O6.Na/c5-1(3(7)8)2(6)4(9)10;/h1-2,5-6H,(H,7,8)(H,9,10);/q;+1/p-1/t1-,2-;/m1./s1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H5O6
Molecular Weight 149.0789
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Tartaric acid is found in many plants such as grapes, tamarinds, pineapples, mulberries and so on. Wine lees (called mud in the US), the sediment collected during the fermentation of grapes, contains potassium bitartrate (potassium hydrogen tartrate) as its major component. L-(+)-tartaric acid is an enantiomer of tartaric acid. Twenty five years before the tetrahedral structure for carbon was proposed in 1874 to explain the optical activity and other properties of organic compounds, Louis Pasteur discovered the existence of enantiomerism in tartaric acid. L-(+)-tartaric acid is widely used in food and beverage as acidity regulator with E number E334.

Originator

Curator's Comment: Scheele first prepared tartaric acid. Louis Pasteur discovered the existence of enantiomerism in tartaric acid

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
CLEARASIL DAILY CLEAR CLEAR SKIN

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Inhibition of leukotriene function can modulate particulate-induced changes in bone cell differentiation and activity.
2001
Studies on the association of 2-thiazolidinecarboxylic acid and antimony potassium tartrate: chiral recognition and prediction of absolute configuration by electrospray ionization mass spectrometry.
2001
Lasofoxifene (CP-336,156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats.
2001 Apr
L-prolinium tartrate.
2001 Apr
A comparison of salts for the crystallization of macromolecules.
2001 Feb
Sarcosinium tartrate.
2001 Feb
Entropy-controlled selectivity in the vinylation of a cyclic chiral nitrone. An efficient route to enantiopure polyhydroxylated pyrrolidines.
2001 Feb 23
Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes.
2001 Jul
Stabilization of minodronic acid in aqueous solution for parenteral formulation.
2001 Jul 3
Dicaffeoyl- or digalloyl pyrrolidine and furan derivatives as HIV integrase inhibitors.
2001 Jun
Classification of Ralstonia pickettii biovar 3/'thomasii' strains (Pickett 1994) and of new isolates related to nosocomial recurrent meningitis as Ralstonia mannitolytica sp. nov.
2001 Mar
Crystal structure analysis and chiral recognition study of Delta-[Ru(bpy)2(py)2][(+)-O,O'-dibenzoylD-tartrate].12H2O and Lambda-[Ru(bpy)2(py)2][(-)-O,O'-dibenzoyl-L-tartrate].12H2O.
2001 Mar 12
Direct resolution of (+/-)-ephedrine and atropine into their enantiomers by impregnated TLC.
2001 May
[Acid phosphatase, ACP (EC 3.1.3.2)].
2001 Nov
Platelet-activating factor modulates a secreted phosphatase activity of the trypanosomatid parasite Herpetomonas muscarum muscarum.
2001 Oct
Direct chiral resolution of tartaric acid in food products by ligand exchange capillary electrophoresis using copper(II)-D-quinic acid as a chiral selector.
2001 Oct 12
Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines.
2001 Sep 15
Preformulation studies for an ultrashort-acting neuromuscular blocking agent GW280430A. I. Buffer and cosolvent effects on the solution stability.
2002
The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor.
2002 Apr
Initial stages of cell-matrix adhesion can be mediated and modulated by cell-surface hyaluronan.
2002 Apr
Chiral versus racemic building blocks in supramolecular chemistry: tartrate salts of organic diamines.
2002 Apr
Towards atomic resolution with crystals grown in gel: the case of thaumatin seen at room temperature.
2002 Aug 1
Retention of anions on silica-based metalloporphyrin stationary phases.
2002 Feb
The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.
2002 Feb
Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells.
2002 Feb
Revision of absolute configuration of enantiomeric (methylenecyclopropyl)carbinols obtained from (R)-(-)- and (S)-(+)-epichlorohydrin and methylenetriphenylphosphorane. Implications for reaction mechanism and improved synthesis of antiviral methylenecyclopropane analogues of nucleosides.
2002 Jan 11
Effect of antibiotics on in vitro and in vivo avian cartilage degradation.
2002 Jan-Mar
In vitro antibiotic susceptibility of field isolates of Mycoplasma synoviae in Argentina.
2002 Jan-Mar
High frequency of phenotypic deviations in Physcomitrella patens plants transformed with a gene-disruption library.
2002 Jul 18
Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice.
2002 Jun
Stereoselective radical reactions of some tartaric and glyceric acid derivatives.
2002 Jun 13
Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo.
2002 Jun 7
Release of an acid phosphatase activity during lily pollen tube growth involves components of the secretory pathway.
2002 May
Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5.
2002 Oct 15
Patents

Sample Use Guides

L-(+)-tartaric acid as a food additive. Acceptable Daily Intake: 0-30 mg/kg
Route of Administration: Oral
In Vitro Use Guide
After incubation in medium containing 50 mM L(+)-tartaric acid, osteoclasts and chondroclasts were heavily stained with reaction product.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:02:06 GMT 2023
Edited
by admin
on Fri Dec 15 15:02:06 GMT 2023
Record UNII
75E63I9H07
Record Status Validated (UNII)
Record Version
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Name Type Language
SODIUM BITARTRATE
II   MART.   MI   WHO-DD  
Systematic Name English
SODIUM BITARTRATE [MART.]
Common Name English
INS-335(I)
Code English
MONOBASIC SODIUM TARTRATE
Common Name English
E-335(I)
Code English
SODIUM HYDROGEN L-TARTRATE
Systematic Name English
Sodium bitartrate [WHO-DD]
Common Name English
MONOSODIUM TARTRATE
Systematic Name English
SODIUM BITARTRATE [II]
Common Name English
BUTANEDIOIC ACID, 2,3-DIHYDROXY- (2R,3R)-, MONOSODIUM SALT
Common Name English
INS NO.335(I)
Code English
MONOSODIUM L-(+)-TARTRATE
Systematic Name English
MONOSODIUM DL-TARTRATE
Common Name English
TARTARIC ACID, MONOSODIUM SALT
Common Name English
SODIUM BITARTRATE [MI]
Common Name English
SODIUM ACID TARTRATE
Common Name English
BUTANEDIOIC ACID, 2,3-DIHYDROXY- (2R,3R)-, SODIUM SALT (1:1)
Common Name English
SODIUM HYDROGEN TARTRATE
Systematic Name English
Classification Tree Code System Code
JECFA EVALUATION INS-335(I)
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
CFR 21 CFR 331.11
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-335(I)
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
CFR 21 CFR 331.15
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
Code System Code Type Description
CAS
526-94-3
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
PRIMARY
FDA UNII
75E63I9H07
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
PRIMARY
SMS_ID
100000078102
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
PRIMARY
EPA CompTox
DTXSID70883423
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
PRIMARY
WIKIPEDIA
MONOSODIUM TARTRATE
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
PRIMARY
ECHA (EC/EINECS)
208-400-9
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
PRIMARY
MERCK INDEX
m9995
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
PRIMARY Merck Index
PUBCHEM
23684900
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
PRIMARY
EVMPD
SUB15273MIG
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
PRIMARY
RXCUI
89900
Created by admin on Fri Dec 15 15:02:06 GMT 2023 , Edited by admin on Fri Dec 15 15:02:06 GMT 2023
PRIMARY RxNorm
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS