SODIUM BITARTRATE

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C4H5O6.Na
Molecular Weight	172.0687
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].O[C@H]([C@@H](O)C([O-])=O)C(O)=O

InChI

InChIKey=NKAAEMMYHLFEFN-ZVGUSBNCSA-M

InChI=1S/C4H6O6.Na/c5-1(3(7)8)2(6)4(9)10;/h1-2,5-6H,(H,7,8)(H,9,10);/q;+1/p-1/t1-,2-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C4H5O6
Molecular Weight	149.0789
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://link.springer.com/article/10.1007/s12045-007-0005-6 | http://www.foodchemadditives.com/products/L-Tartaric-Acid

Tartaric acid is found in many plants such as grapes, tamarinds, pineapples, mulberries and so on. Wine lees (called mud in the US), the sediment collected during the fermentation of grapes, contains potassium bitartrate (potassium hydrogen tartrate) as its major component. L-(+)-tartaric acid is an enantiomer of tartaric acid. Twenty five years before the tetrahedral structure for carbon was proposed in 1874 to explain the optical activity and other properties of organic compounds, Louis Pasteur discovered the existence of enantiomerism in tartaric acid. L-(+)-tartaric acid is widely used in food and beverage as acidity regulator with E number E334.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
skin cleasing 8 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a33a11b2-926e-43bb-8775-d94b730d2c78	Inactive ingredient		Approved 8583	CLEARASIL DAILY CLEAR CLEAR SKIN Approved Use Unknown

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 2252	inhibitor 2438	inhibitor 2507	inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 2153 CYP2C19 2057 UGT2B15 84 CYP19A1 429	OAT4 93 OAT1 395

Drug as perpetrator

Target	Modality	Activity
CYP1A2 2333	inhibitor 4027 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzMzU2IiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDEyMDA4NjEifX0=	no [IC50 >10 uM]
CYP2C19 2141	inhibitor 4027 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzNjIyIiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDEyMDA4NjEifX0=	no [IC50 >10 uM]
CYP2C9 2497	inhibitor 4027 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzMzk3IiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDEyMDA4NjEifX0=	no [IC50 >10 uM]
CYP2D6 2546	inhibitor 4027 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwyODkiLCJ1c2VfY3VzdG9tX3F1ZXJ5Ijp0cnVlLCJzZWFyY2hfdGVybSI6IiIsInRleHRfZmlsdGVyIjoiQ0hFTUJMMTIwMDg2MSJ9fQ==	no [IC50 >10 uM]
CYP3A4 2633	inhibitor 4027 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzNDAiLCJ1c2VfY3VzdG9tX3F1ZXJ5Ijp0cnVlLCJzZWFyY2hfdGVybSI6IiIsInRleHRfZmlsdGVyIjoiQ0hFTUJMMTIwMDg2MSJ9fQ==	no [IC50 >10 uM]
CYP19A1 430	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/875#section=Biological-Test-Results Page: 59.0	no
UGT2B15 84	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/31837310/	yes [Ki 91 uM]

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
OAT1 395	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/37087614/	yes
OAT4 93	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/37087614/	yes

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/875#section=Biological-Test-Results Page: 93.0

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-059382	http://www.3bsc.com/index/pro_info.php?id=98203
abcr GmbH	AB118837	http://www.abcr.de/shop/en/AB118837
abcr GmbH	AB207455	http://www.abcr.de/shop/en/AB207455
Acadechem	ACDS-067423	http://www.acadechemical.com/product/142122
AK Scientific, Inc. (AKSCI)	7165AF	http://www.aksci.com/item_detail.php?cat=7165AF
Alfa Chemistry	AP6106247-A	https://reagents.alfa-chemistry.com/product/sodium-tartrate-dihydrate-cas-6106-24-7-14010.html
Alfa Chemistry	AP6106247-B	https://reagents.alfa-chemistry.com/product/sodium-tartrate-dihydrate-cas-6106-24-7-14011.html
Ambinter	Amb22348226	http://www.ambinter.com/reference/22348226
Anward	ANW-33667	http://www.anward.com/pro_result/23235
Aurora Fine Chemicals LLC	A14.518.215	http://online.aurorafinechemicals.com/info?ID=A14.518.215
Avantor Inc	101225-558	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101225-558
Avantor Inc	101226-150	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101226-150
BOC Sciences	6106-24-7	https://www.bocsci.com/disodium-tartrate-dihydrate-cas-6106-24-7-item-95530.html
Chemspace	CSSB00102632354	https://chem-space.com/CSSB00102632354
Combi-Blocks	QE-8461	http://www.combi-blocks.com/cgi-bin/find.cgi?QE-8461
Fisher Chemical	AL2770100	https://www.fishersci.com/shop/products/aqualine-sodium-tartrate-dihydrate-water-standard-fisher-chemical/AL2770100
Fisher Chemical	S433100	https://www.fishersci.com/shop/products/sodium-l-tartrate-dihydrate-crystalline-certified-fisher-chemical-2/p-192917
Fisher Chemical	S433500	https://www.fishersci.com/shop/products/sodium-l-tartrate-dihydrate-crystalline-certified-fisher-chemical-2/p-192917
Glentham Life Sciences	GK1687	http://www.glentham.com/products/product/GK1687/
iChemical	EBD16533	http://www.ichemical.com/chemicals/cas-6106-24-7
MolPort	MolPort-003-928-192	https://www.molport.com/shop/molecule-link/MolPort-003-928-192
Oakwood	104960	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=196368&ExtHyperLink=1
Oakwood	94747	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=79921&ExtHyperLink=1
Sigma-Aldrich	1614909_USP	https://www.sigmaaldrich.com/catalog/product/usp/1614909?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	228729_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/228729?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	28-4380_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/284380?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	71994_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/71994?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	71995_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/71995?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S051766	http://www.sinfoobiotech.com/product/1055164

PubMed

Title	Date	PubMed
Reversal of multidrug resistance-associated protein-mediated drug resistance in cultured human neuroblastoma cells by the quinolone antibiotic difloxacin.	2001 Jan	11464877
Capillary electrophoresis for evaluating orange juice authenticity: a study on Spanish oranges.	2001 Jan	11170552
A Mg-dependent ecto-ATPase in Leishmania amazonensis and its possible role in adenosine acquisition and virulence.	2001 Jul 1	11414680
Catalytic spectrophotometric determination of vanadium in seawaters based on the bromate oxidative coupling reaction of metol and 2,3,4-trihydroxybenzoic acid.	2001 Jun	11707949
Effect of several organic acids on phosphate adsorption by variable charge soils of central China.	2001 May	11392751
Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport.	2001 May 11	11278867
[Increasing number of Salmonella paratyphi B isolates from slaughtered poultry sent in to the national Salmonella reference laboratory].	2001 May-Jun	11413710
Chemical and biochemical issues related to X-ray crystallography of the ligand-binding domain of estrogen receptor alpha.	2001 May-Jun	11353539
The hygroscopic properties of dicarboxylic and multifunctional acids: measurements and UNIFAC predictions.	2001 Nov 15	11757607
Preformulation studies for an ultrashort-acting neuromuscular blocking agent GW280430A. I. Buffer and cosolvent effects on the solution stability.	2002	11926357
The MRP1-mediated effluxes of arsenic and antimony do not require arsenic-glutathione and antimony-glutathione complex formation.	2002 Apr	12018890
New materials for ESR dosimetry.	2002 Apr	11993477
Acid phosphatases.	2002 Apr	11950951
The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor.	2002 Apr	11937054
Stereoselective synthesis of myo-inositol via ring-closing metathesis: a building block for glycosylphosphatidylinositol (GPI) anchor synthesis.	2002 Apr 18	11950362
Towards atomic resolution with crystals grown in gel: the case of thaumatin seen at room temperature.	2002 Aug 1	12112683
Crystal structure analysis of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase), from Paramecium reveals significant conformational variability.	2002 Jan 11	11779235
A simple spectrophotometric method for the determination of copper in industrial, environmental, biological and soil samples using 2,5-dimercapto-1,3,4-thiadiazole.	2002 Jul	12137377
High frequency of phenotypic deviations in Physcomitrella patens plants transformed with a gene-disruption library.	2002 Jul 18	12123528
Boronic acid receptors for alpha-hydroxycarboxylates: high affinity of Shinkai's glucose receptor for tartrate.	2002 Jul 26	12126445
Engineering the substrate specificity of D-amino-acid oxidase.	2002 Jul 26	12021281
Improving the labeling of S-acetyl NHS-MAG(3)-conjugated morpholino oligomers.	2002 Jul-Aug	12121147
Effects of cyclic pressure on bone marrow cell cultures.	2002 Jun	12071266
Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice.	2002 Jun	12054176
Stereoselective radical reactions of some tartaric and glyceric acid derivatives.	2002 Jun 13	12049511
The separation of racemic crystals into enantiomers by chiral block copolymers.	2002 Jun 3	12180321
Determination of the side-products formed during the nitroxide-mediated bleach oxidation of glucose to glucaric acid.	2002 Jun 5	12039549
Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo.	2002 Jun 7	12052261
Consumption of an omega-3 fatty acids product, INCELL AAFA, reduced side-effects of CPT-11 (irinotecan) in mice.	2002 Mar 18	11953833
Release of an acid phosphatase activity during lily pollen tube growth involves components of the secretory pathway.	2002 May	12099218
Use of disposable GRC electrodes for the detection of phenol and chlorophenols in liquid chromatography.	2002 May	12036123
Crystallization and preliminary X-ray crystallographic analysis of UDP-N-acetylglucosamine acyltransferase from Helicobacter pylori.	2002 May	11976505
Potassium antimonyl tartrate induces reactive oxygen species-related apoptosis in human myeloid leukemic HL60 cells.	2002 May	11956606
Synovial macrophage-osteoclast differentiation in inflammatory arthritis.	2002 Oct	12228163
Ectonucleotide diphosphohydrolase activity in Crithidia deanei.	2002 Oct	12209331
Formation of methylantimony species by an aerobic prokaryote: Flavobacterium sp.	2002 Oct	12209260
Effects of sigma(1) receptor ligand MS-377 on D(2) antagonists-induced behaviors.	2002 Oct	12151023
Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5.	2002 Oct 15	12119043
Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator.	2002 Oct 25	12171919
Symmetric and helical growth of polyacetylene fibers over a single copper crystal derived from copper tartrate decomposition.	2002 Sep 5	12201732

Patents

Sample Use Guides

In Vivo Use Guide

L-( )-tartaric acid as a food additive. Acceptable Daily Intake: 0-30 mg/kg

Route of Administration: Oral

In Vitro Use Guide

After incubation in medium containing 50 mM L( )-tartaric acid, osteoclasts and chondroclasts were heavily stained with reaction product.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:36:05 GMT 2025` Edited by `admin` on `Mon Mar 31 17:36:05 GMT 2025`
Record UNII	75E63I9H07
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

E-335(I)

Preferred Name

English

SODIUM BITARTRATE

Systematic Name

English

SODIUM BITARTRATE [MART.]

Common Name

English

INS-335(I)

Code

English

MONOBASIC SODIUM TARTRATE

Common Name

English

SODIUM HYDROGEN L-TARTRATE

Systematic Name

English

Sodium bitartrate [WHO-DD]

Common Name

English

MONOSODIUM TARTRATE

Systematic Name

English

SODIUM BITARTRATE [II]

Common Name

English

BUTANEDIOIC ACID, 2,3-DIHYDROXY- (2R,3R)-, MONOSODIUM SALT

Common Name

English

INS NO.335(I)

Code

English

MONOSODIUM L-(+)-TARTRATE

Systematic Name

English

MONOSODIUM DL-TARTRATE

Common Name

English

TARTARIC ACID, MONOSODIUM SALT

Common Name

English

SODIUM BITARTRATE [MI]

Common Name

English

SODIUM ACID TARTRATE

Common Name

English

BUTANEDIOIC ACID, 2,3-DIHYDROXY- (2R,3R)-, SODIUM SALT (1:1)

Common Name

English

SODIUM HYDROGEN TARTRATE

Systematic Name

English

Classification Tree Code System Code

JECFA EVALUATION

INS-335(I)