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Details

Stereochemistry ABSOLUTE
Molecular Formula C4H5O6.Na.H2O
Molecular Weight 190.0839
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM BITARTRATE MONOHYDRATE

SMILES

O.[Na+].O[C@H]([C@@H](O)C([O-])=O)C(O)=O

InChI

InChIKey=LLVQEXSQFBTIRD-OLXYHTOASA-M
InChI=1S/C4H6O6.Na.H2O/c5-1(3(7)8)2(6)4(9)10;;/h1-2,5-6H,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t1-,2-;;/m1../s1

HIDE SMILES / InChI

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H6O6
Molecular Weight 150.0868
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Tartaric acid is found in many plants such as grapes, tamarinds, pineapples, mulberries and so on. Wine lees (called mud in the US), the sediment collected during the fermentation of grapes, contains potassium bitartrate (potassium hydrogen tartrate) as its major component. L-(+)-tartaric acid is an enantiomer of tartaric acid. Twenty five years before the tetrahedral structure for carbon was proposed in 1874 to explain the optical activity and other properties of organic compounds, Louis Pasteur discovered the existence of enantiomerism in tartaric acid. L-(+)-tartaric acid is widely used in food and beverage as acidity regulator with E number E334.

Originator

Curator's Comment: Scheele first prepared tartaric acid. Louis Pasteur discovered the existence of enantiomerism in tartaric acid

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
CLEARASIL DAILY CLEAR CLEAR SKIN

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Inhibition of leukotriene function can modulate particulate-induced changes in bone cell differentiation and activity.
2001
Effect of brimonidine tartrate ophthalmic solution 0.2% on pupil size in normal eyes under different luminance conditions.
2001 Apr
A novel and simplified route to the synthesis of N3S chelators for 99mTc labeling.
2001 Aug
Synthesis and evaluation of a C-glycosyl nucleoside as an inhibitor of chitin synthase.
2001 Aug 30
Cinchoninium L-tartrate tetrahydrate.
2001 Dec
Production and chemiluminescent free radical reactions of glyoxal in lipid peroxidation of linoleic acid by the ligninolytic enzyme, manganese peroxidase.
2001 Dec
LAS, a novel selective estrogen receptor modulator with chemopreventive and therapeutic activity in the N-nitroso-N-methylurea-induced rat mammary tumor model.
2001 Dec 15
A comparison of salts for the crystallization of macromolecules.
2001 Feb
Response charactterization of ammonium tartrate solid state pellets for ESR dosimetry with radiotherapeutic photon and electron beams.
2001 Feb
Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase.
2001 Feb
Entropy-controlled selectivity in the vinylation of a cyclic chiral nitrone. An efficient route to enantiopure polyhydroxylated pyrrolidines.
2001 Feb 23
Reversal of multidrug resistance-associated protein-mediated drug resistance in cultured human neuroblastoma cells by the quinolone antibiotic difloxacin.
2001 Jan
Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes.
2001 Jul
A Mg-dependent ecto-ATPase in Leishmania amazonensis and its possible role in adenosine acquisition and virulence.
2001 Jul 1
Stability of chiral domains produced by adsorption of tartaric acid isomers on the Cu(110) surface: a periodic density functional theory study.
2001 Jul 11
Dicaffeoyl- or digalloyl pyrrolidine and furan derivatives as HIV integrase inhibitors.
2001 Jun
Chiral separations of transition metal complexes using capillary zone electrophoresis.
2001 Jun 15
Effect of several organic acids on phosphate adsorption by variable charge soils of central China.
2001 May
Production and characterization of 188Re-C595 antibody for radioimmunotherapy of transitional cell bladder cancer.
2001 May
[Increasing number of Salmonella paratyphi B isolates from slaughtered poultry sent in to the national Salmonella reference laboratory].
2001 May-Jun
Synthesis, characterization, and labeling with 99mTc/188Re of peptide conjugates containing a dithia-bisphosphine chelating agent.
2001 May-Jun
Technetium-99m direct radiolabeling of lanreotide: a somatostatin analog.
2001 Nov
Direct chiral resolution of malic acid in apple juice by ligand-exchange capillary electrophoresis using copper(II)-L-tartaric acid as a chiral selector.
2001 Sep
Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents.
2001 Sep 20
Preformulation studies for an ultrashort-acting neuromuscular blocking agent GW280430A. I. Buffer and cosolvent effects on the solution stability.
2002
The MRP1-mediated effluxes of arsenic and antimony do not require arsenic-glutathione and antimony-glutathione complex formation.
2002 Apr
New materials for ESR dosimetry.
2002 Apr
Acid phosphatases.
2002 Apr
Chiral versus racemic building blocks in supramolecular chemistry: tartrate salts of organic diamines.
2002 Apr
Stereoselective synthesis of myo-inositol via ring-closing metathesis: a building block for glycosylphosphatidylinositol (GPI) anchor synthesis.
2002 Apr 18
Retention of anions on silica-based metalloporphyrin stationary phases.
2002 Feb
Ergotamine-induced anorectal strictures: report of five cases.
2002 Feb
The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.
2002 Feb
Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells.
2002 Feb
Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade.
2002 Jan
Some comparative aspects of the pharmacokinetics of tylosin in buffaloes and cattle.
2002 Jan
Anaerobaculum mobile sp. nov., a novel anaerobic, moderately thermophilic, peptide-fermenting bacterium that uses crotonate as an electron acceptor, and emended description of the genus Anaerobaculum.
2002 Jan
Crystal structure analysis of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase), from Paramecium reveals significant conformational variability.
2002 Jan 11
Revision of absolute configuration of enantiomeric (methylenecyclopropyl)carbinols obtained from (R)-(-)- and (S)-(+)-epichlorohydrin and methylenetriphenylphosphorane. Implications for reaction mechanism and improved synthesis of antiviral methylenecyclopropane analogues of nucleosides.
2002 Jan 11
Effect of antibiotics on in vitro and in vivo avian cartilage degradation.
2002 Jan-Mar
Boronic acid receptors for alpha-hydroxycarboxylates: high affinity of Shinkai's glucose receptor for tartrate.
2002 Jul 26
Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo.
2002 Jun 7
Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice.
2002 Mar 1
Release of an acid phosphatase activity during lily pollen tube growth involves components of the secretory pathway.
2002 May
Potassium antimonyl tartrate induces reactive oxygen species-related apoptosis in human myeloid leukemic HL60 cells.
2002 May
Synovial macrophage-osteoclast differentiation in inflammatory arthritis.
2002 Oct
Effects of sigma(1) receptor ligand MS-377 on D(2) antagonists-induced behaviors.
2002 Oct
Symmetric and helical growth of polyacetylene fibers over a single copper crystal derived from copper tartrate decomposition.
2002 Sep 5
Patents

Sample Use Guides

L-(+)-tartaric acid as a food additive. Acceptable Daily Intake: 0-30 mg/kg
Route of Administration: Oral
In Vitro Use Guide
After incubation in medium containing 50 mM L(+)-tartaric acid, osteoclasts and chondroclasts were heavily stained with reaction product.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:47:08 GMT 2023
Edited
by admin
on Fri Dec 15 17:47:08 GMT 2023
Record UNII
S66F32Y3ZO
Record Status Validated (UNII)
Record Version
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Name Type Language
SODIUM BITARTRATE MONOHYDRATE
MI  
Systematic Name English
SODIUM BITARTRATE MONOHYDRATE [MI]
Common Name English
SODIUM DITARTRATE HYDROGEN
Common Name English
SODIUM ACID TARTRATE MONOHYDRATE
Common Name English
TARTARIC ACID, MONOSODIUM SALT, MONOHYDRATE
Systematic Name English
BUTANEDIOIC ACID, 2,3-DIHYDROXY- (2R,3R)-, SODIUM SALT, HYDRATE (1:1:1)
Common Name English
Code System Code Type Description
MERCK INDEX
m9995
Created by admin on Fri Dec 15 17:47:08 GMT 2023 , Edited by admin on Fri Dec 15 17:47:08 GMT 2023
PRIMARY Merck Index
PUBCHEM
76965350
Created by admin on Fri Dec 15 17:47:08 GMT 2023 , Edited by admin on Fri Dec 15 17:47:08 GMT 2023
PRIMARY
CAS
6131-98-2
Created by admin on Fri Dec 15 17:47:08 GMT 2023 , Edited by admin on Fri Dec 15 17:47:08 GMT 2023
PRIMARY
EPA CompTox
DTXSID60635539
Created by admin on Fri Dec 15 17:47:08 GMT 2023 , Edited by admin on Fri Dec 15 17:47:08 GMT 2023
PRIMARY
FDA UNII
S66F32Y3ZO
Created by admin on Fri Dec 15 17:47:08 GMT 2023 , Edited by admin on Fri Dec 15 17:47:08 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE
PARENT -> SALT/SOLVATE