SODIUM TARTRATE

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C4H4O6.2Na
Molecular Weight	194.0505
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].O[C@H]([C@@H](O)C([O-])=O)C([O-])=O

InChI

InChIKey=HELHAJAZNSDZJO-OLXYHTOASA-L

InChI=1S/C4H6O6.2Na/c5-1(3(7)8)2(6)4(9)10;;/h1-2,5-6H,(H,7,8)(H,9,10);;/q;2*+1/p-2/t1-,2-;;/m1../s1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H4O6
Molecular Weight	148.071
Charge	-2
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://link.springer.com/article/10.1007/s12045-007-0005-6 | http://www.foodchemadditives.com/products/L-Tartaric-Acid

Tartaric acid is found in many plants such as grapes, tamarinds, pineapples, mulberries and so on. Wine lees (called mud in the US), the sediment collected during the fermentation of grapes, contains potassium bitartrate (potassium hydrogen tartrate) as its major component. L-(+)-tartaric acid is an enantiomer of tartaric acid. Twenty five years before the tetrahedral structure for carbon was proposed in 1874 to explain the optical activity and other properties of organic compounds, Louis Pasteur discovered the existence of enantiomerism in tartaric acid. L-(+)-tartaric acid is widely used in food and beverage as acidity regulator with E number E334.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
skin cleasing 8 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a33a11b2-926e-43bb-8775-d94b730d2c78	Inactive ingredient		Approved 8429	CLEARASIL DAILY CLEAR CLEAR SKIN Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-059382	http://www.3bsc.com/index/pro_info.php?id=98203
AK Scientific, Inc. (AKSCI)	7165AF	http://www.aksci.com/item_detail.php?cat=7165AF
Acadechem	ACDS-067423	http://www.acadechemical.com/product/142122
Alfa Chemistry	AP6106247-A	https://reagents.alfa-chemistry.com/product/sodium-tartrate-dihydrate-cas-6106-24-7-14010.html
Alfa Chemistry	AP6106247-B	https://reagents.alfa-chemistry.com/product/sodium-tartrate-dihydrate-cas-6106-24-7-14011.html
Ambinter	Amb22348226	http://www.ambinter.com/reference/22348226
Anward	ANW-33667	http://www.anward.com/pro_result/23235
Aurora Fine Chemicals LLC	A14.518.215	http://online.aurorafinechemicals.com/info?ID=A14.518.215
Avantor Inc	101225-558	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101225-558
Avantor Inc	101226-150	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101226-150
BOC Sciences	6106-24-7	https://www.bocsci.com/disodium-tartrate-dihydrate-cas-6106-24-7-item-95530.html
Chemspace	CSSB00102632354	https://chem-space.com/CSSB00102632354
Combi-Blocks	QE-8461	http://www.combi-blocks.com/cgi-bin/find.cgi?QE-8461
Fisher Chemical	AL2770100	https://www.fishersci.com/shop/products/aqualine-sodium-tartrate-dihydrate-water-standard-fisher-chemical/AL2770100
Fisher Chemical	S433100	https://www.fishersci.com/shop/products/sodium-l-tartrate-dihydrate-crystalline-certified-fisher-chemical-2/p-192917
Fisher Chemical	S433500	https://www.fishersci.com/shop/products/sodium-l-tartrate-dihydrate-crystalline-certified-fisher-chemical-2/p-192917
Glentham Life Sciences	GK1687	http://www.glentham.com/products/product/GK1687/
MolPort	MolPort-003-928-192	https://www.molport.com/shop/molecule-link/MolPort-003-928-192
Oakwood	104960	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=196368&ExtHyperLink=1
Oakwood	94747	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=79921&ExtHyperLink=1
Sigma-Aldrich	28-4380_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/284380?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	228729_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/228729?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	71995_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/71995?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	71994_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/71994?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1614909_USP	https://www.sigmaaldrich.com/catalog/product/usp/1614909?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S051766	http://www.sinfoobiotech.com/product/1055164
abcr GmbH	AB118837	http://www.abcr.de/shop/en/AB118837
abcr GmbH	AB207455	http://www.abcr.de/shop/en/AB207455
iChemical	EBD16533	http://www.ichemical.com/chemicals/cas-6106-24-7

PubMed

Title	Date	PubMed
Vitreous concentration of topically applied brimonidine tartrate 0.2%.	2001 Apr	11297498
Synthesis and evaluation of a C-glycosyl nucleoside as an inhibitor of chitin synthase.	2001 Aug 30	11513824
A comparison of salts for the crystallization of macromolecules.	2001 Feb	11266627
Response charactterization of ammonium tartrate solid state pellets for ESR dosimetry with radiotherapeutic photon and electron beams.	2001 Feb	11229726
Sarcosinium tartrate.	2001 Feb	11173439
Determination of organic acids of low molecular weight and phosphate in soil by capillary electrophoresis.	2001 Jul-Aug	11501905
Chemical and biochemical issues related to X-ray crystallography of the ligand-binding domain of estrogen receptor alpha.	2001 May-Jun	11353539
Technetium-99m direct radiolabeling of lanreotide: a somatostatin analog.	2001 Nov	11573798
Direct chiral resolution of malic acid in apple juice by ligand-exchange capillary electrophoresis using copper(II)-L-tartaric acid as a chiral selector.	2001 Sep	11589292
Oxidation of hydroquinones by the versatile ligninolytic peroxidase from Pleurotus eryngii. H2O2 generation and the influence of Mn2+.	2001 Sep	11532015
The MRP1-mediated effluxes of arsenic and antimony do not require arsenic-glutathione and antimony-glutathione complex formation.	2002 Apr	12018890
New materials for ESR dosimetry.	2002 Apr	11993477
Chiral versus racemic building blocks in supramolecular chemistry: tartrate salts of organic diamines.	2002 Apr	11910165
Thermophysical properties of pharmaceutically compatible buffers at sub-zero temperatures: implications for freeze-drying.	2002 Feb	11883647
The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.	2002 Feb	11818452
Screening method for inherited disorders of purine and pyrimidine metabolism by capillary electrophoresis with reversed electroosmotic flow.	2002 Feb 15	11885862
Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade.	2002 Jan	11899358
Therapy and disease concepts: the history (and future?) of antimony in cancer.	2002 Jan	11892514
Crystal structure analysis of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase), from Paramecium reveals significant conformational variability.	2002 Jan 11	11779235
Revision of absolute configuration of enantiomeric (methylenecyclopropyl)carbinols obtained from (R)-(-)- and (S)-(+)-epichlorohydrin and methylenetriphenylphosphorane. Implications for reaction mechanism and improved synthesis of antiviral methylenecyclopropane analogues of nucleosides.	2002 Jan 11	11777473
High frequency of phenotypic deviations in Physcomitrella patens plants transformed with a gene-disruption library.	2002 Jul 18	12123528
Engineering the substrate specificity of D-amino-acid oxidase.	2002 Jul 26	12021281
Improving the labeling of S-acetyl NHS-MAG(3)-conjugated morpholino oligomers.	2002 Jul-Aug	12121147
Effects of cyclic pressure on bone marrow cell cultures.	2002 Jun	12071266
Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice.	2002 Jun	12054176
Stereoselective radical reactions of some tartaric and glyceric acid derivatives.	2002 Jun 13	12049511
Determination of the side-products formed during the nitroxide-mediated bleach oxidation of glucose to glucaric acid.	2002 Jun 5	12039549
Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo.	2002 Jun 7	12052261
Use of disposable GRC electrodes for the detection of phenol and chlorophenols in liquid chromatography.	2002 May	12036123
Potassium antimonyl tartrate induces reactive oxygen species-related apoptosis in human myeloid leukemic HL60 cells.	2002 May	11956606
Synovial macrophage-osteoclast differentiation in inflammatory arthritis.	2002 Oct	12228163
Ectonucleotide diphosphohydrolase activity in Crithidia deanei.	2002 Oct	12209331

Patents

Sample Use Guides

In Vivo Use Guide

L-(+)-tartaric acid as a food additive. Acceptable Daily Intake: 0-30 mg/kg

Route of Administration: Oral

In Vitro Use Guide

After incubation in medium containing 50 mM L(+)-tartaric acid, osteoclasts and chondroclasts were heavily stained with reaction product.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:10:24 GMT 2023` Edited by `admin` on `Fri Dec 15 15:10:24 GMT 2023`
Record UNII	QTO9JB4MDD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM TARTRATE

Systematic Name

English

DISODIUM L-TARTRATE

Systematic Name

English

SODIUM TARTRATE [MI]

Common Name

English

INS-335(II)

Code

English

DISODIUM TARTRATE [INCI]

Common Name

English

SODIUM DEXTRO-TARTRATE

Common Name

English

BUTANEDIOIC ACID, 2,3-DIHYDROXY- (2R,3R)-, DISODIUM SALT

Common Name

English

SODIUM TARTRATE [FCC]

Common Name

English

SODIUM (+)-TARTRATE

Systematic Name

English

Sodium tartrate [WHO-DD]

Common Name

English

E-335(II)

Code

English

DISODIUM (+)-2,3-DIHYDROXYBUTANEDIOIC ACID

Systematic Name

English

DISODIUM TARTRATE

Official Name

English

INS NO.335(II)

Code

English

SODIUM TARTRATE, L (+)-

Common Name

English

SODIUM TARTRATE [MART.]

Common Name

English

TARTARIC ACID, DISODIUM SALT

Common Name

English

SODIUM TARTRATE [II]

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

INS-335(II)