ANTIMONY POTASSIUM TARTRATE

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C4H2O6.2K.2Sb.3H2O
Molecular Weight	667.873
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ANTIMONY POTASSIUM TARTRATE

Structure Search

SMILES

O.O.O.[K+].[K+].[Sb+3].[Sb+3].[O-][C@H]([C@@H]([O-])C([O-])=O)C([O-])=O.[O-][C@H]([C@@H]([O-])C([O-])=O)C([O-])=O

InChI

InChIKey=WBTCZEPSIIFINA-MSFWTACDSA-J

InChI=1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4/t2*1-,2-;;;;;;;/m11......./s1

HIDE SMILES / InChI

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H4O6
Molecular Weight	148.071
Charge	-2
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Sb
Molecular Weight	121.76
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.whocc.no/atcvet/atcvet_index/?code=QR05CA07https://www.ncbi.nlm.nih.gov/pubmed/5295139 | https://www.ncbi.nlm.nih.gov/pubmed/14851220 | https://www.ncbi.nlm.nih.gov/pubmed/8898332
Curator's Comment: description was created based on several sources, including https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7ef48d40-6d63-440b-a73c-46d89f425936

Stibophen (Fuadin), an organic trivalent antimony compound, has been used for many years in the treatment of schistosomiasis. Stibophen is used as treatment of schistosomiasis by intramuscular injection. Stibophen is known to act by selectively inhibiting worm PFK.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
ATP-dependent 6-phosphofructokinase 21 Target ID: Q27778 Gene ID: NA Gene Symbol: PFK Target Organism: Schistosoma mansoni (Blood fluke) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8898332 \| https://www.ncbi.nlm.nih.gov/pubmed/13446367	Inhibitor 8228

Conditions

Condition	Modality	Targets	Highest Phase	Product
Schistosomiasis 32 Sources: https://www.ncbi.nlm.nih.gov/pubmed/193200 https://www.ncbi.nlm.nih.gov/pubmed/193201 https://www.ncbi.nlm.nih.gov/pubmed/13268811 https://www.ncbi.nlm.nih.gov/pubmed/20292219	Curative		Approved 8360	Fuadin Approved Use Schistosomiasis
Unknown 2565

PubMed

Title	Date	PubMed
Evaluation of fuadin therapy in schistosomiasis japonica.	1951 Apr	14851220

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Jul 05 23:08:16 UTC 2023` Edited by `admin` on `Wed Jul 05 23:08:16 UTC 2023`
Record UNII	DL6OZ476V3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ANTIMONY POTASSIUM TARTRATE

Official Name

English

Antimony potassium tartrate [WHO-DD]

Common Name

English

ANTIMONY POTASSIUM TARTRATE [USP MONOGRAPH]

Common Name

English

DIPOTASSIUM BIS(.MU.-(L-(+)-TARTRATO(4-)))DIANTIMONATE(2-) TRIHYDRATE

Common Name

English

ANTIMONATE(2-), BIS(.MU.-(2,3-DIHYDROXYBUTANEDIOATO(4-)-O(SUP 1),O(SUP 2):O(SUP 3),O(SUP 4)))-DI-, DIPOTASSIUM, TRIHYDRATE, STEREOISOMER

Common Name

English

ANTIMONIUM TARTARICUM

Common Name

English

ANTIMONIUM TARTARICUM [HPUS]

Common Name

English

ANTIMONY POTASSIUM TARTRATE [VANDF]

Common Name

English

ANTIMONY POTASSIUM TARTRATE [MART.]

Common Name

English

ANTIMONY POTASSIUM TARTRATE [MI]

Common Name

English

ANTIMONY POTASSIUM TARTRATE [HSDB]

Common Name

English

ANTIMONY POTASSIUM TARTRATE [INCI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C737