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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C4H2O6.2K.2Sb.3H2O
Molecular Weight 667.873
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ANTIMONY POTASSIUM TARTRATE

SMILES

O.O.O.[K+].[K+].[Sb+3].[Sb+3].[O-][C@H]([C@@H]([O-])C([O-])=O)C([O-])=O.[O-][C@H]([C@@H]([O-])C([O-])=O)C([O-])=O

InChI

InChIKey=WBTCZEPSIIFINA-MSFWTACDSA-J
InChI=1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4/t2*1-,2-;;;;;;;/m11......./s1

HIDE SMILES / InChI
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C4H4O6
Molecular Weight 148.071
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Sb
Molecular Weight 121.76
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7ef48d40-6d63-440b-a73c-46d89f425936

Stibophen (Fuadin), an organic trivalent antimony compound, has been used for many years in the treatment of schistosomiasis. Stibophen is used as treatment of schistosomiasis by intramuscular injection. Stibophen is known to act by selectively inhibiting worm PFK.

Originator

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
ATP-dependent 6-phosphofructokinase
21
Target ID: Q27778
Gene ID: NA
Gene Symbol: PFK
Target Organism: Schistosoma mansoni (Blood fluke)
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
Fuadin

Approved Use

Schistosomiasis
PubMed

PubMed

TitleDatePubMed
Evaluation of fuadin therapy in schistosomiasis japonica.
1951 Apr
Laboratory studies on the joint effects of certain tris (p-aminophenyl) carbonium salts and antimonials as antischistosomal drugs.
1965
Current chemotherapy of schistosomiasis japonica in the Philippines.
1976 Jun
[Substantiation of maximum permissible levels of antimony trioxide and pentasulide in the atmospheric air of inhabitated places].
1989 Apr
Purification, kinetics and inhibition by antimonials of recombinant phosphofructokinase from Schistosoma mansoni.
1996 Oct 30
Antimony impairs nucleotide excision repair: XPA and XPE as potential molecular targets.
2010 Jul 19
Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes.
2012 Jul
Patents

Patents

03976788
20
04062962
20
04197262
20
04562009
22
04596784
20
05025031
25
05463088
20
05656573
25
05776425
20
07713950
20
07737233
22
08268997
20
08354532
21
20080146527
20
20090076227
20
20090124802
20
7361689
20
7615300
20
US3085943
20
US3965016
20
US5232441
21

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:39:06 GMT 2023
Edited
by admin
on Fri Dec 15 15:39:06 GMT 2023
Record UNII
DL6OZ476V3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ANTIMONY POTASSIUM TARTRATE
HSDB   INCI   MART.   MI   USP   VANDF   WHO-DD  
INCI  
Official Name English
Antimony potassium tartrate [WHO-DD]
Common Name English
ANTIMONY POTASSIUM TARTRATE [USP MONOGRAPH]
Common Name English
DIPOTASSIUM BIS(.MU.-(L-(+)-TARTRATO(4-)))DIANTIMONATE(2-) TRIHYDRATE
Common Name English
ANTIMONATE(2-), BIS(.MU.-(2,3-DIHYDROXYBUTANEDIOATO(4-)-O(SUP 1),O(SUP 2):O(SUP 3),O(SUP 4)))-DI-, DIPOTASSIUM, TRIHYDRATE, STEREOISOMER
Common Name English
ANTIMONIUM TARTARICUM
HPUS  
Common Name English
ANTIMONIUM TARTARICUM [HPUS]
Common Name English
ANTIMONY POTASSIUM TARTRATE [VANDF]
Common Name English
ANTIMONY POTASSIUM TARTRATE [MART.]
Common Name English
ANTIMONY POTASSIUM TARTRATE [MI]
Common Name English
ANTIMONY POTASSIUM TARTRATE [HSDB]
Common Name English
ANTIMONY POTASSIUM TARTRATE [INCI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C737
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
EPA PESTICIDE CODE 6201
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
Code System Code Type Description
WIKIPEDIA
ANTIMONY POTASSIUM TARTRATE
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY
CAS
28300-74-5
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY
FDA UNII
DL6OZ476V3
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY
MERCK INDEX
m1961
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY Merck Index
SMS_ID
100000077425
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY
NCI_THESAURUS
C76863
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY
HSDB
1428
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PRIMARY
CHEBI
2761
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PRIMARY
RXCUI
981
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY RxNorm
EVMPD
SUB34747
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY
PUBCHEM
73415808
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PRIMARY
DRUG BANK
DB15587
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY
EVMPD
SUB127075
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
ALTERNATIVE
EVMPD
SUB12916MIG
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY
DAILYMED
DL6OZ476V3
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY
MESH
D000966
Created by admin on Fri Dec 15 15:39:06 GMT 2023 , Edited by admin on Fri Dec 15 15:39:06 GMT 2023
PRIMARY
Related Record Type Details
Structure of ANTIMONY POTASSIUM TARTRATE ANHYDROUS
ANHYDROUS->SOLVATE
Structure of TARTARIC ACID
PARENT -> SALT/SOLVATE
Structure of ANTIMONY CATION (3+)
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of ANTIMONY CATION (3+)
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