DEXTROMORAMIDE TARTRATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H32N2O2.C4H6O6
Molecular Weight	542.6206
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O.C[C@H](CN1CCOCC1)C(C(=O)N2CCCC2)(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=ACRMUSVWIFZVSM-JTHHODAVSA-N

InChI=1S/C25H32N2O2.C4H6O6/c1-21(20-26-16-18-29-19-17-26)25(22-10-4-2-5-11-22,23-12-6-3-7-13-23)24(28)27-14-8-9-15-27;5-1(3(7)8)2(6)4(9)10/h2-7,10-13,21H,8-9,14-20H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t21-;1-,2-/m11/s1

HIDE SMILES / InChI

Molecular Formula	C25H32N2O2
Molecular Weight	392.5338
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C4H6O6
Molecular Weight	150.0868
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1959-01-01_4_page004.html
Curator's Comment: Description was created based on several sources, including https://books.google.ru/books?id=G7As-qawdzMC&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.cbg-meb.nl/documenten/rapporten/2015/09/14/par-dextromoramide | https://medikamio.com/nl-nl/geneesmiddelen/palfium-tablet-5-mg/pil

Dextromoramide is a synthetic strong-acting opioid and full mu-opioid receptor agonist. Dextromoramide is a Schedule I drug illegal to possess. The current indication for Palfium® (dextromoramide) is severe acute or chronic pain requiring opioids, such as post-operative pain, and pain associated with bone fractures, malignancies and acute renal/biliary colic attacks in adults.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Mu opioid receptor 221 Target ID: CHEMBL233 Sources: https://www.cbg-meb.nl/documenten/rapporten/2015/09/14/par-dextromoramide	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1959-01-01_4_page004.html	Primary		Approved 8429	PALFIUM Approved Use Palfium® (dextromoramide) is a synthetic strong-acting opioid and full mu-opioid receptor agonist that has been registered in the Netherlands since 1974. The current indication is severe acute or chronic pain requiring opioids, such as post-operative pain, and pain associated with bone fractures, malignancies and acute renal/biliary colic attacks in adults. Launch Date 1973

PubMed

Title	Date	PubMed
Properties and analysis of dextromoramide and its dosage forms.	1961 Jan	13721787
Effect of methadone and dextromoramide on dopamine metabolism: comparison with haloperidol and amphetamine.	1975 Dec	768800

Patents

Sample Use Guides

In Vivo Use Guide

IM: 15 mg Intra Rectal: 20 mg PO: 0.071 to 0.285 mg/kg SC: 15 mg

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:16:49 GMT 2023` Edited by `admin` on `Fri Dec 15 15:16:49 GMT 2023`
Record UNII	J778U505W5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEXTROMORAMIDE TARTRATE

Common Name

English

DEXTROMORAMIDE TARTRATE [EP MONOGRAPH]

Common Name

English

DEXTROMORAMIDE TARTRATE [MART.]

Common Name

English

Dextromoramide tartrate [WHO-DD]

Common Name

English

(+)-4-(2-METHYL-4-OXO-3,3-DIPHENYL-4-(1-PYRROLIDINYL)BUTYL)MORPHOLINE BITARTRATE

Systematic Name

English

DEXTROMORAMIDE BITARTRATE

Common Name

English

DEXTROMORAMIDE BITARTRATE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67413