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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H32N2O2
Molecular Weight 392.5338
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEXTROMORAMIDE

SMILES

C[C@H](CN1CCOCC1)C(C(=O)N2CCCC2)(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=INUNXTSAACVKJS-OAQYLSRUSA-N
InChI=1S/C25H32N2O2/c1-21(20-26-16-18-29-19-17-26)25(22-10-4-2-5-11-22,23-12-6-3-7-13-23)24(28)27-14-8-9-15-27/h2-7,10-13,21H,8-9,14-20H2,1H3/t21-/m1/s1

HIDE SMILES / InChI

Molecular Formula C25H32N2O2
Molecular Weight 392.5338
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Dextromoramide is a synthetic strong-acting opioid and full mu-opioid receptor agonist. Dextromoramide is a Schedule I drug illegal to possess. The current indication for Palfium® (dextromoramide) is severe acute or chronic pain requiring opioids, such as post-operative pain, and pain associated with bone fractures, malignancies and acute renal/biliary colic attacks in adults.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PALFIUM

Cmax

ValueDoseCo-administeredAnalytePopulation
2000 μg/L
5 mg single, intravenous
DEXTROMORAMIDE plasma
Homo sapiens
40 μg/L
5 mg single, sublingual
DEXTROMORAMIDE plasma
Homo sapiens
106 μg/L
7.5 mg single, oral
DEXTROMORAMIDE plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
1775.4 μg × h/L
5 mg single, intravenous
DEXTROMORAMIDE plasma
Homo sapiens
526 μg × h/L
5 mg single, sublingual
DEXTROMORAMIDE plasma
Homo sapiens
0.81 mg × h/L
7.5 mg single, oral
DEXTROMORAMIDE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
9.02 h
5 mg single, intravenous
DEXTROMORAMIDE plasma
Homo sapiens
12.37 h
5 mg single, sublingual
DEXTROMORAMIDE plasma
Homo sapiens
12.3 h
7.5 mg single, oral
DEXTROMORAMIDE plasma
Homo sapiens

Doses

AEs

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
IM: 15 mg Intra Rectal: 20 mg PO: 0.071 to 0.285 mg/kg SC: 15 mg
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
9S4S6CIY83
Record Status Validated (UNII)
Record Version