Details
Stereochemistry | ABSOLUTE |
Molecular Formula | 2C16H20N2O2.C4H6O6 |
Molecular Weight | 694.7712 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN(C)C(=O)OC1=CC=C2CC[C@@H](NCC#C)C2=C1.CCN(C)C(=O)OC3=CC=C4CC[C@@H](NCC#C)C4=C3
InChI
InChIKey=PRLVBVAJMQZMJN-OGOSNNLPSA-N
InChI=1S/2C16H20N2O2.C4H6O6/c2*1-4-10-17-15-9-7-12-6-8-13(11-14(12)15)20-16(19)18(3)5-2;5-1(3(7)8)2(6)4(9)10/h2*1,6,8,11,15,17H,5,7,9-10H2,2-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t2*15-;1-,2-/m111/s1
Molecular Formula | C16H20N2O2 |
Molecular Weight | 272.3422 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | C4H6O6 |
Molecular Weight | 150.0868 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
LADOSTIGIL, a rasagiline derivative, is a reversible acetylcholinesterase and butyrylcholinesterase inhibitor with neuroprotective properties. It also acts as an irreversible brain monoamine oxidases inhibitor. It is under development for the treatment of neurodegenerative disorders like dementia and Alzheimer's disease.
CNS Activity
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells. | 2003 Feb 7 |
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Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. | 2004 Mar 25 |
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The neurochemical and behavioral effects of the novel cholinesterase-monoamine oxidase inhibitor, ladostigil, in response to L-dopa and L-tryptophan, in rats. | 2005 Oct |
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Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats. | 2007 Mar |
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The neuroprotective mechanism of action of the multimodal drug ladostigil. | 2008 May 1 |
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Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk. | 2009 Dec 1 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:05:59 GMT 2025
by
admin
on
Mon Mar 31 18:05:59 GMT 2025
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Record UNII |
2J1346C51H
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Record Status |
Validated (UNII)
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Record Version |
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-
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Official Name | English | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C47792
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NCI_THESAURUS |
C667
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Code System | Code | Type | Description | ||
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300000044446
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CHEMBL255231
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209394-46-7
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C76072
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QQ-52
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2J1346C51H
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11607225
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DTXSID60175107
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admin on Mon Mar 31 18:05:59 GMT 2025 , Edited by admin on Mon Mar 31 18:05:59 GMT 2025
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PRIMARY |
Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE | |||
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PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |