LADOSTIGIL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H20N2O2
Molecular Weight	272.3422
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(C)C(=O)OC1=CC2=C(CC[C@H]2NCC#C)C=C1

InChI

InChIKey=LHXOCOHMBFOVJS-OAHLLOKOSA-N

InChI=1S/C16H20N2O2/c1-4-10-17-15-9-7-12-6-8-13(11-14(12)15)20-16(19)18(3)5-2/h1,6,8,11,15,17H,5,7,9-10H2,2-3H3/t15-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C16H20N2O2
Molecular Weight	272.3422
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67423264 | https://www.ncbi.nlm.nih.gov/pubmed/11205137 | https://www.ncbi.nlm.nih.gov/pubmed/22280345

LADOSTIGIL, a rasagiline derivative, is a reversible acetylcholinesterase and butyrylcholinesterase inhibitor with neuroprotective properties. It also acts as an irreversible brain monoamine oxidases inhibitor. It is under development for the treatment of neurodegenerative disorders like dementia and Alzheimer's disease.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic-pituitary-adrenal axis in male and female prenatally stressed rats.	2005 Aug	15830235
Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression.	2006	17017566
The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30.	2006 Dec	17168653
The application of proteomics and genomics to the study of age-related neurodegeneration and neuroprotection.	2007 Feb	17115941
The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na, K)-, Mg-ATPase activities, antioxidant status, and learning performance of aged rats.	2008 Aug	19043511
The neuroprotective mechanism of action of the multimodal drug ladostigil.	2008 May 1	18508575
The neurotrophic and neuroprotective effects of psychotropic agents.	2009	19877500
Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?	2009 Apr 2	19461897
Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons.	2009 Aug 12	19672295
The New Inhibitor of Monoamine Oxidase, M30, has a Neuroprotective Effect Against Dexamethasone-Induced Brain Cell Apoptosis.	2010	21103012

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:45:17 GMT 2023` Edited by `admin` on `Sat Dec 16 17:45:17 GMT 2023`
Record UNII	SW3H1USR4Q
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LADOSTIGIL

Official Name

English

ladostigil [INN]

Common Name

English

TV-3326 FREE BASE

Code

English

(3R)-3-(PROP-2-YN-1-YLAMINO)-2,3-DIHYDRO-1H-INDEN-5-YL ETHYL(METHYL)CARBAMATE

Systematic Name

English

CARBAMIC ACID, ETHYL(METHYL)-, (3R)-2,3-DIHYDRO-3-(2-PROPYNYLAMINO)-1H-INDEN-5-YL ESTER

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C667