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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 20:58:58 GMT 2025
Edited
by admin
on Tue Apr 01 20:58:58 GMT 2025
Protein Type ENZYME
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
B5QXZ49C7Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMINE OXIDASE (FLAVIN-CONTAINING) A
Common Name English
MAO-A
Preferred Name English
MONOAMINE OXIDASE A (HUMAN GENE MAOA)
Common Name English
MONOAMINE OXIDASE TYPE A
Common Name English
MAOA
Common Name English
Code System Code Type Description
CAS
479852-35-2
Created by admin on Tue Apr 01 20:58:58 GMT 2025 , Edited by admin on Tue Apr 01 20:58:58 GMT 2025
ALTERNATIVE
WIKIPEDIA
MONOAMINE OXIDASE
Created by admin on Tue Apr 01 20:58:58 GMT 2025 , Edited by admin on Tue Apr 01 20:58:58 GMT 2025
PRIMARY
CAS
624651-39-4
Created by admin on Tue Apr 01 20:58:58 GMT 2025 , Edited by admin on Tue Apr 01 20:58:58 GMT 2025
ALTERNATIVE
CAS
481302-91-4
Created by admin on Tue Apr 01 20:58:58 GMT 2025 , Edited by admin on Tue Apr 01 20:58:58 GMT 2025
ALTERNATIVE
CAS
391962-32-6
Created by admin on Tue Apr 01 20:58:58 GMT 2025 , Edited by admin on Tue Apr 01 20:58:58 GMT 2025
PRIMARY
CAS
480770-54-5
Created by admin on Tue Apr 01 20:58:58 GMT 2025 , Edited by admin on Tue Apr 01 20:58:58 GMT 2025
ALTERNATIVE
FDA UNII
B5QXZ49C7Y
Created by admin on Tue Apr 01 20:58:58 GMT 2025 , Edited by admin on Tue Apr 01 20:58:58 GMT 2025
PRIMARY
UNIPROT
P21397
Created by admin on Tue Apr 01 20:58:58 GMT 2025 , Edited by admin on Tue Apr 01 20:58:58 GMT 2025
PRIMARY
EC (ENZYME CLASS)
EC 1.4.3.4
Created by admin on Tue Apr 01 20:58:58 GMT 2025 , Edited by admin on Tue Apr 01 20:58:58 GMT 2025
PRIMARY
Related Record Type Details
Structure of PHENYLPROPANOLAMINE
INHIBITOR -> METABOLIC ENZYME
Structure of SAFINAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of TYRAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of LINEZOLID
INHIBITOR -> METABOLIC ENZYME
Structure of Dimethyltryptamine
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of INDANTADOL
INHIBITOR -> TARGET
Structure of INDOPAN
INHIBITOR -> TARGET
Structure of MMDA
INHIBITOR -> METABOLIC ENZYME
Structure of OCTYLAMINE, C-11
SUBSTRATE->ENZYME
Structure of LADOSTIGIL
INHIBITOR -> TARGET
Structure of RWJ-432205 FREE BASE
INHIBITOR -> TARGET
Structure of Mebufotenin
SUBSTRATE -> METABOLIC ENZYME
Structure of Epinephrine,(±)-
SUBSTRATE -> METABOLIC ENZYME
Structure of 7-METHYL-.ALPHA.-ETHYLTRYPTAMINE
INHIBITOR -> TARGET
Structure of DOPAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of 5-FLUORO-AMT
INHIBITOR -> TARGET
Strong inhibitor. As can be seen, 5-FMT dose-dependently inhibited only the activity of MAO A similarly in these regions of the brain with no effect on MAOB. The IC50 values (the dose to inhibit MAO A activity 50%) in these regions of the brain were about 11 mg/kg (0.05 mmol/kg).
Structure of OCTYLAMINE, C-11
RADIOLIGAND->TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_383] SERINE DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_1] METHIONINE N-ACETYLMETHIONINE 9J12WX5B6A
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL
NIH
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