Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Tue Apr 01 19:48:14 GMT 2025
by
admin
on
Tue Apr 01 19:48:14 GMT 2025
|
| Protein Type | ENZYME |
| Protein Sub Type | MONOAMINE OXIDASE |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
3OV8HVI592
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
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Preferred Name | English | ||
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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P27338
Created by
admin on Tue Apr 01 19:48:14 GMT 2025 , Edited by admin on Tue Apr 01 19:48:14 GMT 2025
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PRIMARY | |||
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MONOAMINE OXIDASE B
Created by
admin on Tue Apr 01 19:48:14 GMT 2025 , Edited by admin on Tue Apr 01 19:48:14 GMT 2025
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PRIMARY | |||
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3OV8HVI592
Created by
admin on Tue Apr 01 19:48:14 GMT 2025 , Edited by admin on Tue Apr 01 19:48:14 GMT 2025
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PRIMARY | |||
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EC 1.4.3.4
Created by
admin on Tue Apr 01 19:48:14 GMT 2025 , Edited by admin on Tue Apr 01 19:48:14 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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RADIOLIGAND->TARGET |
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INHIBITOR -> METABOLIC ENZYME |
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INHIBITOR -> TARGET |
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INHIBITOR -> METABOLIC ENZYME |
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INHIBITOR -> METABOLIC ENZYME |
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RADIOLIGAND->TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IRREVERSIBLE INHIBITOR
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INHIBITOR -> METABOLIC ENZYME |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> METABOLIC ENZYME |
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SUBSTRATE->ENZYME |
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INHIBITOR -> TARGET |
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INHIBITOR -> METABOLIC ENZYME | |||
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INHIBITOR -> TARGET |
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SUBSTRATE -> METABOLIC ENZYME |
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INHIBITOR -> TARGET |
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SUBSTRATE -> METABOLIC ENZYME |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Ki
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INHIBITOR -> METABOLIC ENZYME |
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INHIBITOR -> METABOLIC ENZYME |
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INHIBITOR -> METABOLIC ENZYME |
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INHIBITOR -> TARGET |
IRREVERSIBLE INHIBITOR
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INHIBITOR -> TARGET |
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INHIBITOR -> METABOLIC ENZYME |
MAO inhibition can lead to peripheral or central neurotransmitter accumulation, with potentially serious consequences. MAO inhibitors, when taken in combination with vasoconstrictors, such as pseudoephedrine, or high dietary tyramine can cause sudden blood pressure elevations that may lead to hypertensive crises. Combination with serotonergic agents may lead to rare, but potentially life-threatening, serotonin syndrome
IC50
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RADIOLIGAND->TARGET |
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Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_1] | N-TERMINUS | SERINE | N-ACETYLSERINE | W98518XGZ3 | |
| AMINO ACID SUBSTITUTION | [1_396] | SITE_SPECIFIC | CYSTEINE | S-8ALPHA-FAD CYSTEINE | N124966P04 | |
| AMINO ACID SUBSTITUTION | [1_51] | SITE_SPECIFIC | LYSINE | N6-ACETYLLYSINE | 470AD5VY1X |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) | CHEMICAL |
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| Molecular Formula | CHEMICAL |
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