Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C53H87NO19.C4H6O6 |
Molecular Weight | 1192.34 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 23 / 23 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@@]1(C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O1)O[C@@H]2[C@@H](C)O[C@@]([H])(O[C@H]3[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(C)=C\[C@H](CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)[C@@H](CC)OC(=O)C[C@@H](OC(C)=O)[C@@H]3C)[C@H](O)[C@H]2N(C)C
InChI
InChIKey=OLLSDNUHBJHKJS-XKORHJEPSA-N
InChI=1S/C53H87NO19.C4H6O6/c1-16-38-36(26-65-52-49(64-15)48(63-14)44(60)31(7)67-52)22-28(4)17-18-37(57)29(5)23-35(19-20-55)46(30(6)39(69-34(10)56)24-41(59)70-38)73-51-45(61)43(54(12)13)47(32(8)68-51)72-42-25-53(11,62)50(33(9)66-42)71-40(58)21-27(2)3;5-1(3(7)8)2(6)4(9)10/h17-18,20,22,27,29-33,35-36,38-39,42-52,60-62H,16,19,21,23-26H2,1-15H3;1-2,5-6H,(H,7,8)(H,9,10)/b18-17+,28-22+;/t29-,30+,31-,32-,33+,35+,36-,38-,39-,42+,43-,44-,45-,46-,47-,48-,49-,50+,51+,52-,53-;1-,2-/m11/s1
Molecular Formula | C4H6O6 |
Molecular Weight | 150.0868 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | C53H87NO19 |
Molecular Weight | 1042.2532 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 21 / 21 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ema.europa.eu/en/documents/product-information/aivlosin-epar-product-information_en.pdf | https://www.ncbi.nlm.nih.gov/pubmed/19767637 | https://www.ncbi.nlm.nih.gov/pubmed/25185108 | https://www.ncbi.nlm.nih.gov/pubmed/29696149http://www.ecoanimalhealth.com/us/US04PIM-6A5%20Aivlosin%20Water%20soluble%20granules%20Pack%20Insert%20-%20USA%20-%20Pigs.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26392896
Sources: https://www.ema.europa.eu/en/documents/product-information/aivlosin-epar-product-information_en.pdf | https://www.ncbi.nlm.nih.gov/pubmed/19767637 | https://www.ncbi.nlm.nih.gov/pubmed/25185108 | https://www.ncbi.nlm.nih.gov/pubmed/29696149http://www.ecoanimalhealth.com/us/US04PIM-6A5%20Aivlosin%20Water%20soluble%20granules%20Pack%20Insert%20-%20USA%20-%20Pigs.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26392896
Tylvalosin (TVS) is a third-generation macrolide drug used for prophylaxis and treatment of mycoplasma. Tylvalosin, the active ingredient of Aivlosin
625 mg/g Water Soluble Granules (ECO
Animal Health, UK), is a modern macrolide
that has shown its effectiveness in the control
of porcine proliferative enteropathy, EP and swine dysentery. Aivlosin is indicated for the control of porcine proliferative enteropathy (PPE)
associated with Lawsonia intracellularis infection in
groups of swine in buildings experiencing an outbreak
of PPE. Tylvalosin tartrate is a macrolide antibiotic that has antibacterial activity against Gram-positive, some
Gram-negative organisms and mycoplasma. It acts by inhibiting protein synthesis in the bacteria cell.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | AIVLOSIN Approved UseControl of porcine proliferative enteropathy (PPE)
associated with Lawsonia intracellularis infection in
groups of swine in buildings experiencing an outbreak
of PPE. Launch Date2012 |
PubMed
Title | Date | PubMed |
---|---|---|
In vitro activity of tylvalosin against Spanish field strains of Mycoplasma hyopneumoniae. | 2014 Nov 29 |
|
Use of tylvalosin in the control of porcine enzootic pneumonia. | 2015 |
|
Antibiotic susceptibility profiles of Mycoplasma sp. 1220 strains isolated from geese in Hungary. | 2016 Aug 19 |
|
Antimicrobial susceptibility of Brachyspira hyodysenteriae in Switzerland. | 2016 Jun |
Patents
Sample Use Guides
Control of porcine proliferative enteropathy: 50 ppm tylvalosin in drinking water for five consecutive
days
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27543140
Tylvalosin (MIC50 0.5 ug/ml) was found to be the most effective drug against M. sp. 1220.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:28:37 GMT 2023
by
admin
on
Fri Dec 15 16:28:37 GMT 2023
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Record UNII |
AL5667FY0W
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C254
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |