PROXORPHAN TARTRATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C19H25NO2.C4H6O6
Molecular Weight	748.9014
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O.OC1=CC=C2C[C@@H]3[C@@H]4CCOC[C@]4(CCN3CC5CC5)C2=C1.OC6=CC=C7C[C@@H]8[C@@H]9CCOC[C@]9(CCN8CC%10CC%10)C7=C6

InChI

InChIKey=RLECFUYBVBJYHJ-ADFQYSHBSA-N

InChI=1S/2C19H25NO2.C4H6O6/c2*21-15-4-3-14-9-18-16-5-8-22-12-19(16,17(14)10-15)6-7-20(18)11-13-1-2-13;5-1(3(7)8)2(6)4(9)10/h2*3-4,10,13,16,18,21H,1-2,5-9,11-12H2;1-2,5-6H,(H,7,8)(H,9,10)/t2*16-,18+,19-;1-,2-/m001/s1

HIDE SMILES / InChI

Molecular Formula	C19H25NO2
Molecular Weight	299.4073
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C4H6O6
Molecular Weight	150.0868
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6137557 | https://www.ncbi.nlm.nih.gov/pubmed/8394915 | https://www.ncbi.nlm.nih.gov/pubmed/2566680 | https://www.ncbi.nlm.nih.gov/pubmed/1331411

Proxorphan is a N-substituted 6-oxamorphinane patented by American pharmaceutical company Bristol-Myers Co. as opioid analgesic and antitussive drug. Proxorphan acts as a κ-opioid receptor partial agonist and to a lesser extent as a μ-opioid receptor partial agonist.

Originator

Approval Year

PubMed

Title	Date	PubMed
Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists.	1989-05	2566680

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:47:10 GMT 2025` Edited by `admin` on `Mon Mar 31 17:47:10 GMT 2025`
Record UNII	T32BM3AM71
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BL-5572M

Preferred Name

English

PROXORPHAN TARTRATE

Official Name

English

PROXORPHAN TARTRATE [USAN]

Common Name

English

6-OXAMORPHINAN-3-OL, 17-(CYCLOPROPYLMETHYL)-, (S-(R*,R*))-2,3-DIHYDROXYBUTANEDIOATE (2:1) (SALT)

Common Name

English

(-)-(4AR,5R,10BS)-13-(CYCLOPROPYLMETHYL)-4,4A,5,6-TETRAHYDRO-3H-5,10B-(IMINOETHANO)-1H-NAPHTHO(1,2-C)-PYRAN-9-OL D-(-)-TARTRATE (2:1) (SALT)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67413