PROXORPHAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H25NO2
Molecular Weight	299.4073
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CCOC[C@@]13CCN(CC4CC4)[C@@H]2CC5=C3C=C(O)C=C5

InChI

InChIKey=USEITRSTDJBLBU-UHOSZYNNSA-N

InChI=1S/C19H25NO2/c21-15-4-3-14-9-18-16-5-8-22-12-19(16,17(14)10-15)6-7-20(18)11-13-1-2-13/h3-4,10,13,16,18,21H,1-2,5-9,11-12H2/t16-,18+,19-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H25NO2
Molecular Weight	299.4073
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6137557 | https://www.ncbi.nlm.nih.gov/pubmed/8394915 | https://www.ncbi.nlm.nih.gov/pubmed/2566680 | https://www.ncbi.nlm.nih.gov/pubmed/1331411

Proxorphan is a N-substituted 6-oxamorphinane patented by American pharmaceutical company Bristol-Myers Co. as opioid analgesic and antitussive drug. Proxorphan acts as a κ-opioid receptor partial agonist and to a lesser extent as a μ-opioid receptor partial agonist.

Originator

Approval Year

PubMed

Title	Date	PubMed
Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists.	1989 May	2566680

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:36:46 UTC 2023` Edited by `admin` on `Fri Dec 15 18:36:46 UTC 2023`
Record UNII	TFE8T279QV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROXORPHAN

Official Name

English

6-OXAMORPHINAN-3-OL, 17-(CYCLOPROPYLMETHYL)-

Systematic Name

English

proxorphan [INN]

Common Name

English

(-)-(4AR,5R,10BS)-13-(CYCLOPROPYLMETHYL)-4,4A,5,6-TETRAHYDRO-3H-5,10B-(IMINOETHANO)-1H-NAPHTHO(1,2-C)-PYRAN-9-OL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1506