U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:34:04 GMT 2023
Edited
by admin
on Sat Dec 16 11:34:04 GMT 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
NJ1Q2Q7LO5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CANNABINOID RECEPTOR 1
Common Name English
CANN6
Common Name English
CNR1
Common Name English
CB1 RECEPTOR
Common Name English
CB1
Common Name English
CNR
Common Name English
CB-1
Common Name English
CB-R
Common Name English
Code System Code Type Description
UNIPROT
P21554
Created by admin on Sat Dec 16 11:34:14 GMT 2023 , Edited by admin on Sat Dec 16 11:34:14 GMT 2023
PRIMARY
PHAROS
P21554
Created by admin on Sat Dec 16 11:34:14 GMT 2023 , Edited by admin on Sat Dec 16 11:34:14 GMT 2023
PRIMARY
FDA UNII
NJ1Q2Q7LO5
Created by admin on Sat Dec 16 11:34:14 GMT 2023 , Edited by admin on Sat Dec 16 11:34:14 GMT 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_77
N 1_83
N 1_112
Related Record Type Details
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
WEAK AGONIST->TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
NEGATIVE ALLOSTERIC MODULATOR->TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
∆9-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation.
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
Ki
ACTIVATOR -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Strong agonist
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
EC50
ACTIVATOR -> TARGET
Inhibits a anandamide selective transport mechanism (reuptake)
AGONIST -> TARGET
Ki
AGONIST -> TARGET
RADIOLIGAND->TARGET
AGONIST -> TARGET
INVERSE AGONIST->TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
RADIOLIGAND->TARGET
Kd
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
EC50
LIGAND->TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
INHIBITOR -> TARGET
AM281 is a selective CB1 receptor antagonis
BINDING
IC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
Ki
INVERSE AGONIST->TARGET
Rimonabant was the first CB1r antagonist to be approved for the treatment of obesity in Europe (Van Gaal et al., 2005; Henness et al., 2006). It was withdrawn from the market in 2008 because it was found to cause a significant drug-related risk of serious psychiatric disorders including anxiety and depression (Christensen et al., 2007).
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Emax 99% of CP55940
EC50
AGONIST -> TARGET
Ki
INVERSE AGONIST->TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
INVERSE AGONIST->TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Very potent cannabinoid effects in animal studies.
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
A potent agonist
INHIBITOR -> TARGET
BINDING
IC50
AGONIST -> TARGET
EC50
RADIOLIGAND->TARGET
IC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
EC50
WEAK AGONIST->TARGET
Ki
INHIBITOR -> TARGET
IC50
AGONIST -> TARGET
AGONIST -> TARGET
Natural agonist
AGONIST -> TARGET
EC50
AGONIST -> TARGET
EC50
INHIBITOR -> TARGET
INVERSE AGONIST->TARGET
IC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
Assumed from CBD and CBDA
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Ki
AGONIST -> TARGET
Assumed target and agonist
AGONIST -> TARGET
AGONIST -> TARGET
5F-CUMYL-PEGACLONE acts as a potent full agonist of the CB1 receptor.
AGONIST -> TARGET
AGONIST -> TARGET
Exhibit cannabinoid (CB) receptor activity but overall potency is expected to be low.
AGONIST -> TARGET
Ki
RADIOLIGAND->TARGET
RADIOLIGAND->TARGET
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
ASSUMED ACTIVITY FROM ANALOGS
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Emax=142% relative to JWH-018
EC50
AGONIST -> TARGET
Potent agonist of both the CB1 receptor and the CB2 receptor.
EC50
AGONIST -> TARGET
An endogenous agonist
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
INHIBITOR -> TARGET
Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist
BINDING
IC50
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Ki
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL