U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 16:34:09 GMT 2025
Edited
by admin
on Tue Apr 01 16:34:09 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
NJ1Q2Q7LO5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CANN6
Preferred Name English
CANNABINOID RECEPTOR 1
Common Name English
CNR1
Common Name English
CB1 RECEPTOR
Common Name English
CB1
Common Name English
CNR
Common Name English
CB-1
Common Name English
CB-R
Common Name English
Code System Code Type Description
UNIPROT
P21554
Created by admin on Tue Apr 01 16:34:09 GMT 2025 , Edited by admin on Tue Apr 01 16:34:09 GMT 2025
PRIMARY
PHAROS
P21554
Created by admin on Tue Apr 01 16:34:09 GMT 2025 , Edited by admin on Tue Apr 01 16:34:09 GMT 2025
PRIMARY
FDA UNII
NJ1Q2Q7LO5
Created by admin on Tue Apr 01 16:34:09 GMT 2025 , Edited by admin on Tue Apr 01 16:34:09 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_77
N 1_83
N 1_112
Related Record Type Details
Structure of NMP-7
AGONIST -> TARGET
Structure of AZD-2207
INHIBITOR -> TARGET
Structure of HU-310
AGONIST -> TARGET
Ki
Structure of XLR-11
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of AB-CHMINACA
AGONIST -> TARGET
Ki
Structure of MDMB-CHMCZCA
AGONIST -> TARGET
EC50
Structure of ZEVAQUENABANT
INHIBITOR -> TARGET
Structure of Selonabant
INHIBITOR -> TARGET
Structure of APINACA
AGONIST -> TARGET
EC50
Structure of MDMB-FUBICA
AGONIST -> TARGET
Structure of MA-CHMINACA
AGONIST -> TARGET
Ki
Structure of 5F-ADBICA
AGONIST -> TARGET
EC50
Structure of EG-2201
AGONIST -> TARGET
Ki
Structure of ADB-HEXINACA
AGONIST -> TARGET
Structure of JWH-091
LIGAND->TARGET
NIMACIMAB
INHIBITOR -> TARGET
Structure of PB-22
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of NABILONE
AGONIST -> TARGET
Ki
Structure of DRINABANT
INHIBITOR -> TARGET
Structure of 5F-ADB-PINACA
AGONIST -> TARGET
EC50
Structure of SERINOLAMIDE A
AGONIST -> TARGET
Structure of Rezosicone
INHIBITOR -> TARGET
cannabinoid CB1 receptor signalling inhibitor
Structure of FDU-NNE1
AGONIST -> TARGET
Ki
Structure of AB-FUBINACA 3-FLUOROBENZYL ISOMER
AGONIST -> TARGET
Structure of JWH-080
AGONIST -> TARGET
Ki
Structure of PTI-2
AGONIST -> TARGET
Structure of TAK-937
AGONIST -> TARGET
IC50
Structure of AM-2201
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of ADB-5’Br-PINACA
AGONIST -> TARGET
Structure of CUMYL-CB-MEGACLONE
AGONIST -> TARGET
Structure of 5F-CUMYL-P7AICA
AGONIST -> TARGET
EC50
Structure of MN-18
AGONIST -> TARGET
Ki
Structure of 5-FLUORO-MN-18
AGONIST -> TARGET
Ki
Structure of CUMYL-NBMINACA
AGONIST -> TARGET
Structure of MDMB-BINACA
AGONIST -> TARGET
Structure of ADB-CHMINACA
AGONIST -> TARGET
Ki
Structure of 5-FLUORO-AMB-PICA
AGONIST -> TARGET
Ki
Structure of MO-CHMINAKA
AGONIST -> TARGET
Ki
Structure of UR-144
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of PTI-3
AGONIST -> TARGET
Structure of SDB-005
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of RCS-4 C4
WEAK AGONIST->TARGET
EC50
Structure of MCHB-1
AGONIST -> TARGET
Ki
Structure of NE-CHMIMO
AGONIST -> TARGET
Structure of GAT100
NEGATIVE ALLOSTERIC MODULATOR->TARGET
Structure of AB-FUBINACA 2-FLUOROBENZYL ISOMER
AGONIST -> TARGET
Ki
Structure of AMG-1
AGONIST -> TARGET
Structure of Pregnenolone
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
?9-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation.
Structure of 5F-ADB
AGONIST -> TARGET
Ki
Structure of AM-679 (CANNABINOID)
AGONIST -> TARGET
Structure of THJ-2201
AGONIST -> TARGET
Ki
Structure of PERROTTETINENE
ACTIVATOR -> TARGET
Structure of AM-4030
AGONIST -> TARGET
Ki
Structure of CP-55940
AGONIST -> TARGET
Strong agonist
EC50
Structure of APP-CHMINACA
AGONIST -> TARGET
Ki
Structure of STS-135
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of 5-FLUORO-MN-24
AGONIST -> TARGET
Structure of DRONABINOL
AGONIST -> TARGET
EC50
Structure of SGT-151
AGONIST -> TARGET
Structure of AB-PINACA
AGONIST -> TARGET
EC50
Structure of 4F-ABINACA
AGONIST -> TARGET
Structure of APP-FUBINACA
AGONIST -> TARGET
Ki
Structure of PX-1
AGONIST -> TARGET
Ki
Structure of MDMB-4EN-PINACA
AGONIST -> TARGET
Structure of ADBICA
AGONIST -> TARGET
EC50
Structure of AM-404
ACTIVATOR -> TARGET
Inhibits a anandamide selective transport mechanism (reuptake)
Structure of JWH-387
AGONIST -> TARGET
Ki
Structure of Delta-8-Tetrahydrocannabinol
AGONIST -> TARGET
Structure of JHU-75528 C-11
RADIOLIGAND->TARGET
Structure of PF-03550096
AGONIST -> TARGET
Structure of TARANABANT
INVERSE AGONIST->TARGET
Structure of 5F-EMB-PINACA
AGONIST -> TARGET
Structure of ABO-4EN-PINACA
AGONIST -> TARGET
Structure of ADB-BICA
AGONIST -> TARGET
Structure of FUB-JWH-018
AGONIST -> TARGET
Ki
Structure of NESS-040C5
AGONIST -> TARGET
Ki
Structure of AB-002
AGONIST -> TARGET
EC50
Structure of AMB-FUBINACA
AGONIST -> TARGET
Ki
Structure of AMB
AMB
AGONIST -> TARGET
Ki
Structure of 4F-MDMB-BICA
AGONIST -> TARGET
EC50
Structure of JWH-018
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of CUMYL-PICA
AGONIST -> TARGET
Ki
Structure of 5-FLUORO-AB-PINACA
AGONIST -> TARGET
EC50
Structure of 5F-SDB-003
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of FAB-144
AGONIST -> TARGET
Structure of AM-11542
AGONIST -> TARGET
Ki
Structure of CUMYL-THPINACA
AGONIST -> TARGET
Ki
Structure of CP-55940 H-3
RADIOLIGAND->TARGET
Kd
Structure of METHANANDAMIDE, (±)-
AGONIST -> TARGET
Structure of NNL-1
AGONIST -> TARGET
Structure of MMB-018
AGONIST -> TARGET
Structure of ADB-FUBINACA
AGONIST -> TARGET
EC50
Structure of CID-16020046
LIGAND->TARGET
Structure of 5F-SDB-004
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of 5F-SDB-006
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of TETRAHYDROCANNABIVARIN
INHIBITOR -> TARGET
Structure of 5F-SDB-002
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of AM-281
INHIBITOR -> TARGET
AM281 is a selective CB1 receptor antagonis
BINDING
IC50
Structure of 5-FLUORO-AB-PICA, (±)-
AGONIST -> TARGET
EC50
Structure of ADBICA, (±)-
AGONIST -> TARGET
EC50
Structure of MN-24
AGONIST -> TARGET
Structure of ART-2713
AGONIST -> TARGET
Structure of IBIPINABANT
INHIBITOR -> TARGET
Structure of EDMB-4EN-PINACA
AGONIST -> TARGET
Structure of Lixosicone
INHIBITOR -> TARGET
Structure of 6-Methyl-3-[2-nitro-1-(2-thienyl)ethyl]-2-phenyl-1H-indole
POSITIVE ALLOSTERIC MODULATOR->TARGET
Structure of 5-FLUORO-PB-22
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of EAM-2201
AGONIST -> TARGET
Ki
Structure of RIMONABANT
INVERSE AGONIST->TARGET
Rimonabant was the first CB1r antagonist to be approved for the treatment of obesity in Europe (Van Gaal et al., 2005; Henness et al., 2006). It was withdrawn from the market in 2008 because it was found to cause a significant drug-related risk of serious psychiatric disorders including anxiety and depression (Christensen et al., 2007).
Ki
Structure of WIN-55212-2
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of NE-40 C-11
NON-BINDER->OFF TARGET
Ki
Structure of THJ-018
AGONIST -> TARGET
Structure of BZO-CHMOXIZID
AGONIST -> TARGET
Emax 99% of CP55940
EC50
Structure of F-2201
AGONIST -> TARGET
Ki
Structure of CANNABIDIOL
INVERSE AGONIST->TARGET
Structure of SDB-004
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of RCS-3
AGONIST -> TARGET
EC50
Structure of PSB-SB-1202
AGONIST -> TARGET
Structure of MDMB-CHMINACA
AGONIST -> TARGET
Ki
Structure of AB-FUBINACA
AGONIST -> TARGET
EC50
Structure of 5-FLUORO PHENYL-PICA
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of JD-5037
INVERSE AGONIST->TARGET
Structure of 5-FLUORO-CUMYL-PICA
AGONIST -> TARGET
Ki
Structure of ADB-FUBICA
AGONIST -> TARGET
EC50
Structure of O-774
AGONIST -> TARGET
Very potent cannabinoid effects in animal studies.
Ki
Structure of RCS-4
AGONIST -> TARGET
EC50
Structure of CUMYL-4CN-BINACA
AGONIST -> TARGET
A potent agonist
Structure of CP-55940
INHIBITOR -> TARGET
BINDING
IC50
Structure of MDMB-FUBINACA
AGONIST -> TARGET
EC50
Structure of MK-9740 F-18
RADIOLIGAND->TARGET
IC50
Structure of AB-PICA
AGONIST -> TARGET
EC50
Structure of RCS-2
AGONIST -> TARGET
EC50
Structure of MEPIRAPIM
WEAK AGONIST->TARGET
Ki
Structure of Monlunabant
INHIBITOR -> TARGET
IC50
Structure of 2-(2-Chlorophenyl)-1-(4-chlorophenyl)-5-ethyl-N-1-piperidinyl-1H-imidazole-4-carboxamideDE
INHIBITOR -> TARGET
Ki
Structure of NNL-2
AGONIST -> TARGET
Structure of ANANDAMIDE
AGONIST -> TARGET
Natural agonist
Structure of JWH-018
AGONIST -> TARGET
EC50
Structure of ADB-PINACA
AGONIST -> TARGET
EC50
Structure of ROSONABANT
INHIBITOR -> TARGET
Structure of MK-9740
INVERSE AGONIST->TARGET
IC50
Structure of EG-018
AGONIST -> TARGET
Ki
Structure of AB-FUBICA
AGONIST -> TARGET
EC50
Structure of 5-FLUORO-AMP
AGONIST -> TARGET
Ki
Structure of AB-001 (cannabinoid)
AGONIST -> TARGET
EC50
Structure of 4F-MDMB-BINACA
AGONIST -> TARGET
Structure of BIPICANA
AGONIST -> TARGET
Structure of 5F-EDMB-PICA
AGONIST -> TARGET
Structure of APICA
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of PX-2
AGONIST -> TARGET
Structure of EPM-301
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
Assumed from CBD and CBDA
Structure of OTENABANT
INHIBITOR -> TARGET
Structure of 5-FLUORO-AB-PICA
INHIBITOR -> TARGET
Ki
Structure of CHO-4'Me-5'Br-FUBOXPYRA
AGONIST -> TARGET
Assumed target and agonist
Structure of AM-679
AGONIST -> TARGET
Structure of MMB-FUBICA
AGONIST -> TARGET
Structure of 5F-CUMYL-PEGACLONE
AGONIST -> TARGET
5F-CUMYL-PEGACLONE acts as a potent full agonist of the CB1 receptor.
Structure of CBL-018
AGONIST -> TARGET
Structure of ADB-5Br-INACA
AGONIST -> TARGET
Exhibit cannabinoid (CB) receptor activity but overall potency is expected to be low.
Structure of FUBIMINA
AGONIST -> TARGET
Ki
Structure of FMPEP-D2 F-18
RADIOLIGAND->TARGET
Structure of MEPPEP C-11
RADIOLIGAND->TARGET
Ki
Structure of SURINABANT
INHIBITOR -> TARGET
Structure of UR-144 N-5-HYDROXYPENTYL
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of JWH-307
AGONIST -> TARGET
Structure of KN-387271
AGONIST -> TARGET
Structure of CL-2201
AGONIST -> TARGET
Ki
Structure of N-(2S,3S)-3-ETHYL-3-DIDEMETHYL 5-FLUORO ADB-PINACA
AGONIST -> TARGET
Ki
Structure of AZD-1175
INHIBITOR -> TARGET
Structure of SDB-006
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of AB-BICA
AGONIST -> TARGET
ASSUMED ACTIVITY FROM ANALOGS
Structure of BZODZ-EPYR
AGONIST -> TARGET
Structure of 5-BROMO APINACA
AGONIST -> TARGET
Structure of METHANANDAMIDE
AGONIST -> TARGET
Structure of 5F-MDMB-P7AICA
AGONIST -> TARGET
Emax=142% relative to JWH-018
EC50
Structure of 5F-MDMB-PICA
AGONIST -> TARGET
Potent agonist of both the CB1 receptor and the CB2 receptor.
EC50
Structure of 2-ARACHIDONOYLGLYCEROL
AGONIST -> TARGET
An endogenous agonist
Structure of SDB-003
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of RIMONABANT
INHIBITOR -> TARGET
Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist
BINDING
IC50
Structure of ABO-4EN-PINACA, (±)-
AGONIST -> TARGET
Structure of ADB-FUBIATA
AGONIST -> TARGET
EC50
Structure of 5-CHLORO-AB-PINACA
AGONIST -> TARGET
Ki
Structure of CMX-020
AGONIST -> TARGET
Structure of 5F-CUMYL-PINACA
AGONIST -> TARGET
Structure of PTI-1
AGONIST -> TARGET
Structure of DRONABINOL
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
Structure of ADB-4EN-PINACA
AGONIST -> TARGET
Structure of MDMB-CHMICA
AGONIST -> TARGET
Ki
Structure of TM-38837
INHIBITOR -> TARGET
INVERSE AGONIST/ANTAGONIST
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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