CANNABINOID RECEPTOR 1

Approval Year

Substance Class	Protein Created by `admin` on `Sun Dec 18 07:56:22 UTC 2022` Edited by `admin` on `Sun Dec 18 07:56:22 UTC 2022`
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	NJ1Q2Q7LO5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CANNABINOID RECEPTOR 1

Common Name

English

CANN6

Common Name

English

CB1 RECEPTOR

Common Name

English

CB1

Common Name

English

CNR

Common Name

English

CB-1`

Common Name

English

CB-R

Common Name

English

Code System Code Type Description

UNIPROT

P21554

Created by admin on Sun Dec 18 07:56:33 UTC 2022 , Edited by admin on Sun Dec 18 07:56:33 UTC 2022

PRIMARY

PHAROS

P21554

Created by admin on Sun Dec 18 07:56:33 UTC 2022 , Edited by admin on Sun Dec 18 07:56:33 UTC 2022

PRIMARY

FDA UNII

NJ1Q2Q7LO5

Created by admin on Sun Dec 18 07:56:33 UTC 2022 , Edited by admin on Sun Dec 18 07:56:33 UTC 2022

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_77
N	1_83
N	1_112

Related Record Type Details


					8G2SU6V9L7

NMP-7

AGONIST -> TARGET

Amount:


					0D295FLV8W

HU-310

AGONIST -> TARGET

Qualification:

Amount:


					L2M8B977ZE

XLR-11

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					QG3J28E7L8

AB-CHMINACA

AGONIST -> TARGET

Qualification:

Amount:


					RIO7RT8MFX

MDMB-CHMCZCA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					T7JYL5VB4H

ZEVAQUENABANT

INHIBITOR -> TARGET

Amount:


					4RNU8C6XXW

ANEB-001

INHIBITOR -> TARGET

Amount:


					MHR0400Y84

APINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					K53ZMB4NR6

MDMB-FUBICA

AGONIST -> TARGET


					OU56JJP891

MA-CHMINACA

AGONIST -> TARGET

Qualification:

Amount:


					U9H280G9O7

5F-ADBICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					X0IJ1PKG2Q

EG-2201

AGONIST -> TARGET

Qualification:

Amount:


					85TS31SOL3

NIMACIMAB

INHIBITOR -> TARGET


					QM6J8F29FE

PB-22

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					2N4O9L084N

NABILONE

AGONIST -> TARGET

Qualification:

Amount:


					8CZ9946YZ8

5F-ADB-PINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					7AX37Z58VV

SERINOLAMIDE A

AGONIST -> TARGET

Amount:


					M5H92FEG4W

FDU-NNE1

AGONIST -> TARGET

Qualification:

Amount:


					VX6CM75L92

AB-FUBINACA 3-FLUOROBENZYL ISOMER

AGONIST -> TARGET

Amount:


					SEL385TU4Y

JWH-080

AGONIST -> TARGET

Qualification:

Amount:


					W0MO88040Q

PTI-2

AGONIST -> TARGET

Amount:


					TBJ0966F1O

AM-2201

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					U43QX7LH63

CUMYL-CB-MEGACLONE

AGONIST -> TARGET

Amount:


					V3J3TQ3UPP

5F-CUMYL-P7AICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					GP2N1PG5X2

MN-18

AGONIST -> TARGET

Qualification:

Amount:


					522ZC95042

5-FLUORO-MN-18

AGONIST -> TARGET

Qualification:

Amount:


					KXN3TSW3C3

CUMYL-NBMINACA

AGONIST -> TARGET

Amount:


					SL4C60689M

ADB-CHMINACA

AGONIST -> TARGET

Qualification:

Amount:


					744M0WHE80

5-FLUORO-AMB-PICA

AGONIST -> TARGET

Qualification:

Amount:


					Z5N9WL7X4P

MO-CHMINAKA

AGONIST -> TARGET

Qualification:

Amount:


					1TYA7HVP1B

UR-144

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					BE9L8378LU

PTI-3

AGONIST -> TARGET

Amount:


					Z6XWV5U765

SDB-005

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					W8QNY2T4YC

MCHB-1

AGONIST -> TARGET

Qualification:

Amount:


					5FWB35TKQ2

NE-CHMIMO

AGONIST -> TARGET


					JA6FTF7C5A

GAT100

NEGATIVE ALLOSTERIC MODULATOR->TARGET

Amount:


					D5UV8X4SEM

AB-FUBINACA 2-FLUOROBENZYL ISOMER

AGONIST -> TARGET

Qualification:

Amount:


					Q7S86DY7UF

AMG-1

AGONIST -> TARGET

Amount:


					FD7BD1M9FY

5F-ADB

AGONIST -> TARGET

Qualification:

Amount:


					61TFT4BO1C

AM-679 (CANNABINOID)

AGONIST -> TARGET


					D7P051IW0T

THJ-2201

AGONIST -> TARGET

Qualification:

Amount:


					HZ8N3GKD3U

PERROTTETINENE

ACTIVATOR -> TARGET

Amount:


					KFY70972J5

CP-55940

AGONIST -> TARGET

Comments:

Strong agonist

Qualification:

EC50

Amount:


					3877T06H05

APP-CHMINACA

AGONIST -> TARGET

Qualification:

Amount:


					E6917946XH

STS-135

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					3T22QDP4D9

5-FLUORO-MN-24

AGONIST -> TARGET

Amount:


					7J8897W37S

DRONABINOL

AGONIST -> TARGET

Qualification:

EC50

Amount:


					CUT2RV7EIQ

SGT-151

AGONIST -> TARGET

Amount:


					6J3KC3S2PA

AB-PINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					PWE2A57W2L

4F-ABINACA

AGONIST -> TARGET

Amount:


					TW71LSK9DG

APP-FUBINACA

AGONIST -> TARGET

Qualification:

Amount:


					BJ7SBQ2H5I

PX-1

AGONIST -> TARGET

Qualification:

Amount:


					K2DZN2TDD6

MDMB-4EN-PINACA

AGONIST -> TARGET


					P0248QCZ04

ADBICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					XVJ94H0U21

AM-404

ACTIVATOR -> TARGET

Comments:

Inhibits a anandamide selective transport mechanism (reuptake)


					9FJY4287ZP

JWH-387

AGONIST -> TARGET

Qualification:

Amount:


					B49D0HH807

.DELTA.8-TETRAHYDROCANNABINOL

AGONIST -> TARGET

Amount:


					8YHH21923L

JHU-75528 C-11

RADIOLIGAND->TARGET

Amount:


					E8S33VNW75

PF-03550096

AGONIST -> TARGET


					64OSW0N4YB

5F-EMB-PINACA

AGONIST -> TARGET


					MM6K732EQE

ADB-BICA

AGONIST -> TARGET

Amount:


					U0Z5KO073G

FUB-JWH-018

AGONIST -> TARGET

Qualification:

Amount:


					P6H2AAY2GE

NESS-040C5

AGONIST -> TARGET

Qualification:

Amount:


					4PH0NMD7GJ

AB-002

AGONIST -> TARGET

Qualification:

EC50

Amount:


					TY9AKI870R

AMB-FUBINACA

AGONIST -> TARGET

Qualification:

Amount:


					0ETP8M4H3E

AMB

AGONIST -> TARGET

Qualification:

Amount:


					FVN7GWR8S7

4F-MDMB-BICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					G391998J57

JWH-018

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					H4APZ90T9U

CUMYL-PICA

AGONIST -> TARGET

Qualification:

Amount:


					3L83B2298V

5-FLUORO-AB-PINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					S0JSR220TR

5F-SDB-003

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					B9JT6F9X8V

FAB-144

AGONIST -> TARGET

Amount:


					6R5GTC3QVB

CUMYL-THPINACA

AGONIST -> TARGET

Qualification:

Amount:


					63WDT9CZ3Y

METHANANDAMIDE, (±)-

AGONIST -> TARGET

Amount:


					8NXZ2B3EJ4

NNL-1

AGONIST -> TARGET

Amount:


					2V3HAX6RM7

MMB-018

AGONIST -> TARGET

Amount:


					05235E1S2O

ADB-FUBINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					5AUY4Y2UPU

CID-16020046

LIGAND->TARGET


					FP569278V0

5F-SDB-004

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					4UP4SXX8BW

5F-SDB-006

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					HX8KIC8HSH

5F-SDB-002

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					W6Z0932HYU

5-FLUORO-AB-PICA, (±)-

AGONIST -> TARGET

Qualification:

EC50

Amount:


					Q71G788A6H

ADBICA, (±)-

AGONIST -> TARGET

Qualification:

EC50

Amount:


					7FVT9P642K

MN-24

AGONIST -> TARGET

Amount:


					0J0035E9FT

ART-2713

AGONIST -> TARGET

Amount:


					QCB63R9792

5-FLUORO-PB-22

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					RML78EN3XE

RIMONABANT

INVERSE AGONIST->TARGET

Comments:

Rimonabant was the first CB1r antagonist to be approved for the treatment of obesity in Europe (Van Gaal et al., 2005; Henness et al., 2006). It was withdrawn from the market in 2008 because it was found to cause a significant drug-related risk of serious psychiatric disorders including anxiety and depression (Christensen et al., 2007).

Qualification:

Amount:


					5H31GI9502

WIN-55212-2

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					B39WNG6743

THJ-018

AGONIST -> TARGET

Amount:


					W4JEN9G47K

BZO-CHMOXIZID

AGONIST -> TARGET

Comments:

Emax 99% of CP55940

Qualification:

EC50

Amount:


					K9H6459WGA

F-2201

AGONIST -> TARGET

Qualification:

Amount:


					19GBJ60SN5

CANNABIDIOL

INVERSE AGONIST->TARGET


					2P77W9B21O

SDB-004

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					429P6KRK5A

PSB-SB-1202

AGONIST -> TARGET

Amount:


					Z6EXBVG316

MDMB-CHMINACA

AGONIST -> TARGET

Qualification:

Amount:


					I7PZF0KTFK

AB-FUBINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					3X4PHX3PGF

5-FLUORO PHENYL-PICA

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					ENZ75DG2Z6

JD-5037

INVERSE AGONIST->TARGET


					7BN4RS63UV

5-FLUORO-CUMYL-PICA

AGONIST -> TARGET

Qualification:

Amount:


					S3ABP24K72

ADB-FUBICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					77GNH26GH3

O-774

AGONIST -> TARGET

Comments:

Very potent cannabinoid effects in animal studies.

Qualification:

Amount:


					V6DM582RV1

CUMYL-4CN-BINACA

AGONIST -> TARGET

Comments:

A potent agonist


					544DR70TN4

MDMB-FUBINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					WEV89ETP9R

MK-9740 F-18

RADIOLIGAND->TARGET

Qualification:

IC50

Amount:


					BWQ0BJ2OGX

AB-PICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					W6OZW1T05K

MEPIRAPIM

WEAK AGONIST->TARGET

Qualification:

Amount:


					4G8X27X87A

MRI-1891

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					R5CLJ9ZS5H

NNL-2

AGONIST -> TARGET

Amount:


					G391998J57

JWH-018

AGONIST -> TARGET

Qualification:

EC50

Amount:


					U1Q4F41C9U

ADB-PINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					7HQ54W9RYH

MK-9740

INVERSE AGONIST->TARGET

Qualification:

IC50

Amount:


					5G2788GL5G

EG-018

AGONIST -> TARGET

Qualification:

Amount:


					U6SUE53VVY

AB-FUBICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					FSE9R26430

PTI-1

AGONIST -> TARGET


					DK24ID0BCL

5-FLUORO-AMP

AGONIST -> TARGET

Qualification:

Amount:


					H657DIA015

AB-001 (cannabinoid)

AGONIST -> TARGET

Qualification:

EC50

Amount:


					ZH38UTM145

4F-MDMB-BINACA

AGONIST -> TARGET

Amount:


					PR85BBU47K

BIPICANA

AGONIST -> TARGET

Amount:


					HKU510FH74

APICA

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					MJ9UWE9QAR

PX-2

AGONIST -> TARGET

Amount:


					J8211Y53EF

OTENABANT

INHIBITOR -> TARGET


					DTI87HQ3GT

5-FLUORO-AB-PICA

INHIBITOR -> TARGET

Qualification:

Amount:


					65KJ8P7M9D

AM-679

AGONIST -> TARGET


					7S7IFQ9PPG

5F-CUMYL-PEGACLONE

AGONIST -> TARGET

Comments:

5F-CUMYL-PEGACLONE acts as a potent full agonist of the CB1 receptor.

Amount:


					B3EM4XQ2QX

CBL-018

AGONIST -> TARGET

Amount:


					U96GD9R3UZ

FUBIMINA

AGONIST -> TARGET

Qualification:

Amount:


					XZ39M85EQB

FMPEP-D2 F-18

RADIOLIGAND->TARGET

Amount:


					CS3P21MZK4

MEPPEP C-11

RADIOLIGAND->TARGET

Qualification:

Amount:


					4MC625LVID

UR-144 N-5-HYDROXYPENTYL

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					06QTR14ONW

JWH-307

AGONIST -> TARGET

Amount:


					SRX4T6TMUS

KN-387271

AGONIST -> TARGET


					BAB5UV995D

CL-2201

AGONIST -> TARGET

Qualification:

Amount:


					2QB22HNV5B

N-(2S,3S)-3-ETHYL-3-DIDEMETHYL 5-FLUORO ADB-PINACA

AGONIST -> TARGET

Qualification:

Amount:


					MM02A5A302

SDB-006

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					JS8UEW5PEV

AB-BICA

AGONIST -> TARGET

Comments:

ASSUMED ACTIVITY FROM ANALOGS

Amount:


					WSQ49D7D2Q

BZODZ-EPYR

AGONIST -> TARGET

Amount:


					37ZM2K3RZA

5-BROMO APINACA

AGONIST -> TARGET

Amount:


					F4U8EF3PBH

METHANANDAMIDE

AGONIST -> TARGET

Amount:


					B2U5NV8ZMN

5F-MDMB-P7AICA

AGONIST -> TARGET

Comments:

Emax=142% relative to JWH-018

Qualification:

EC50

Amount:


					NG3U6O970A

5F-MDMB-PICA

AGONIST -> TARGET

Comments:

Potent agonist of both the CB1 receptor and the CB2 receptor.

Qualification:

EC50

Amount:


					8D239QDW64

2-ARACHIDONOYLGLYCEROL

AGONIST -> TARGET

Comments:

An endogenous agonist

Amount:


					60V195Q93I

SDB-003

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					15Q075Q5LO

5-CHLORO-AB-PINACA

AGONIST -> TARGET

Qualification:

Amount:


					CVL1MSR5Z2

CMX-020

AGONIST -> TARGET


					E827UUV3S9

5F-CUMYL-PINACA

AGONIST -> TARGET

Amount:


					7J8897W37S

DRONABINOL

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB1

Qualification:

EC50

Amount:


					76QQ7SDU32

ADB-4EN-PINACA

AGONIST -> TARGET

Amount:


					X6JI7EA6EJ

MDMB-CHMICA

AGONIST -> TARGET

Qualification:

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL