MN-18

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C30H29N3O
Molecular Weight	447.5708
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MN-18

Structure Search

SMILES

CCCCCC1=CC=C(CN2N=C(C(=O)NC3=CC=CC4=CC=CC=C34)C5=C2C=CC=C5)C=C1

InChI

InChIKey=BLOQUZQMKJZVQE-UHFFFAOYSA-N

InChI=1S/C30H29N3O/c1-2-3-4-10-22-17-19-23(20-18-22)21-33-28-16-8-7-14-26(28)29(32-33)30(34)31-27-15-9-12-24-11-5-6-13-25(24)27/h5-9,11-20H,2-4,10,21H2,1H3,(H,31,34)

HIDE SMILES / InChI

Molecular Formula	C30H29N3O
Molecular Weight	447.5708
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Cannabinoid CB2 receptor 71 Target ID: CHEMBL253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29549157	Agonist 2678		1.233 nM [EC50]
Cannabinoid CB1 receptor 85 Target ID: CHEMBL218 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29549157	Agonist 2678		2.028 nM [EC50]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:50:39 UTC 2023` Edited by `admin` on `Sat Dec 16 11:50:39 UTC 2023`
Record UNII	GP2N1PG5X2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MN-18

Common Name

English

1H-INDAZOLE-3-CARBOXAMIDE, N-1-NAPHTHALENYL-1-PENTYL-

Systematic Name

English

N-(NAPHTHALEN-1-YL)-1-PENTYL-1H-INDAZOLE-3-CARBOXAMIDE

Systematic Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-MN-18

Created by admin on Sat Dec 16 11:50:39 UTC 2023 , Edited by admin on Sat Dec 16 11:50:39 UTC 2023

Code System Code Type Description

CAS

1391484-80-2

Created by admin on Sat Dec 16 11:50:39 UTC 2023 , Edited by admin on Sat Dec 16 11:50:39 UTC 2023

PRIMARY

FDA UNII

GP2N1PG5X2

Created by admin on Sat Dec 16 11:50:39 UTC 2023 , Edited by admin on Sat Dec 16 11:50:39 UTC 2023

PRIMARY

WIKIPEDIA

MN-18

Created by admin on Sat Dec 16 11:50:39 UTC 2023 , Edited by admin on Sat Dec 16 11:50:39 UTC 2023

PRIMARY

MN 18 is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug. It is the indazole core analogue of NNE1. Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of MN-18 may release 1-naphthylamine, a known carcinogen. MN-18 is banned in Sweden.

MANUFACTURER PRODUCT INFORMATION

MN-18

Created by admin on Sat Dec 16 11:50:39 UTC 2023 , Edited by admin on Sat Dec 16 11:50:39 UTC 2023

PRIMARY

MN-18 is a synthetic cannabinoid modeled after AKB48 (APINACA, Item No. 11566), with the adamantyl group replaced by a naphthalenyl group. The physiological and toxicological properties of this compound are unknown. This product is intended for forensic and research applications.

EPA CompTox

DTXSID301010033

Created by admin on Sat Dec 16 11:50:39 UTC 2023 , Edited by admin on Sat Dec 16 11:50:39 UTC 2023

PRIMARY

PUBCHEM

154925762

Created by admin on Sat Dec 16 11:50:39 UTC 2023 , Edited by admin on Sat Dec 16 11:50:39 UTC 2023

PRIMARY

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