CANNABINOID RECEPTOR 2

Approval Year

Substance Class	Protein
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	SKEU5X23RI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CANNABINOID RECEPTOR TYPE 2

Preferred Name

English

CANNABINOID RECEPTOR 2

Common Name

English

CB2

Common Name

English

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Code System

Code

Type

Description

UNIPROT

P34972

PRIMARY

FDA UNII

SKEU5X23RI

PRIMARY

PHAROS

P34972

PRIMARY

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Subunit 0

Glycosylation Type

HUMAN

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Glycosylation Link Type	Site
N	1_11

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Related Record

Type

Details


					G391998J57

JWH-018

AGONIST -> TARGET

Qualification:

EC50

Amount:

22 NANOMOLAR (average)


					4NHS962LCE

JWH-359

AGONIST -> TARGET

Comments:

Selectivity of around 220 times for CB2 over CB1 receptors.

Qualification:

Ki

Amount:

13 NANOMOLAR (average)


					S0JSR220TR

5F-SDB-003

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:

29 NANOMOLAR (average)

581F7DFA9B

OLORINAB

AGONIST -> TARGET


					05235E1S2O

ADB-FUBINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:

3.5 NANOMOLAR (average)

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_335] [1_336] [1_352]				DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_338]				THREONINE PHOSPHATE	3L4WX7B1EI

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C1807H2855N466O504P4S24
MOL_WEIGHT	CHEMICAL

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