CANNABINOID RECEPTOR 2

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 12:12:00 GMT 2023` Edited by `admin` on `Sat Dec 16 12:12:00 GMT 2023`
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	SKEU5X23RI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CANNABINOID RECEPTOR 2

Common Name

English

CANNABINOID RECEPTOR TYPE 2

Common Name

English

CB2

Common Name

English

Code System Code Type Description

UNIPROT

P34972

Created by admin on Sat Dec 16 12:12:10 GMT 2023 , Edited by admin on Sat Dec 16 12:12:10 GMT 2023

PRIMARY

FDA UNII

SKEU5X23RI

Created by admin on Sat Dec 16 12:12:10 GMT 2023 , Edited by admin on Sat Dec 16 12:12:10 GMT 2023

PRIMARY

PHAROS

P34972

Created by admin on Sat Dec 16 12:12:10 GMT 2023 , Edited by admin on Sat Dec 16 12:12:10 GMT 2023

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_11

Related Record Type Details


					G391998J57

JWH-018

AGONIST -> TARGET

Qualification:

EC50

Amount:


					4NHS962LCE

JWH-359

AGONIST -> TARGET

Comments:

Selectivity of around 220 times for CB2 over CB1 receptors.

Qualification:

Amount:


					S0JSR220TR

5F-SDB-003

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:

581F7DFA9B

OLORINAB

AGONIST -> TARGET


					05235E1S2O

ADB-FUBINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					X0IJ1PKG2Q

EG-2201

AGONIST -> TARGET

Qualification:

Amount:


					V6DM582RV1

CUMYL-4CN-BINACA

AGONIST -> TARGET

Comments:

A potent agonist


					9132NB1UJR

GSK-554418A

AGONIST -> TARGET


					544DR70TN4

MDMB-FUBINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					S723GJY405

SER-601

AGONIST -> TARGET


					7J8897W37S

DRONABINOL

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					D5UV8X4SEM

AB-FUBINACA 2-FLUOROBENZYL ISOMER

AGONIST -> TARGET

Amount:


					W6Z0932HYU

5-FLUORO-AB-PICA, (±)-

AGONIST -> TARGET

Qualification:

EC50

Amount:


					D7P051IW0T

THJ-2201

AGONIST -> TARGET

Qualification:

Amount:


					Q71G788A6H

ADBICA, (±)-

AGONIST -> TARGET

Qualification:

EC50

Amount:


					19GBJ60SN5

CANNABIDIOL

INVERSE AGONIST->TARGET

Amount:


					61TFT4BO1C

AM-679 (CANNABINOID)

AGONIST -> TARGET


					KFY70972J5

CP-55940

AGONIST -> TARGET

Comments:

Strong agonist

Qualification:

EC50

Amount:


					U1Q4F41C9U

ADB-PINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					4PH0NMD7GJ

AB-002

AGONIST -> TARGET

Qualification:

EC50

Amount:


					BAB5UV995D

CL-2201

AGONIST -> TARGET

Qualification:

Amount:


					U96GD9R3UZ

FUBIMINA

AGONIST -> TARGET

Qualification:

Amount:


					GP2N1PG5X2

MN-18

AGONIST -> TARGET

Qualification:

Amount:


					9FJY4287ZP

JWH-387

AGONIST -> TARGET

Qualification:

Amount:


					L2M8B977ZE

XLR-11

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					0J0035E9FT

ART-2713

AGONIST -> TARGET

Amount:


					Z6XWV5U765

SDB-005

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					W8QNY2T4YC

MCHB-1

AGONIST -> TARGET

Qualification:

EC50

Amount:


					8WXU5YRE25

MN-25

AGONIST -> TARGET

Comments:

MN-25 (UR-12) acts as a reasonably selective agonist of peripheral cannabinoid receptors. It has moderate affinity for CB2 receptors with a Ki of 11 nM.

Qualification:

Amount:


					5R7X34Y6Q1

TEDALINAB

AGONIST -> TARGET


					OGN7X90BT8

LENABASUM

AGONIST -> TARGET

Amount:


					CVL1MSR5Z2

CMX-020

AGONIST -> TARGET


					E8S33VNW75

PF-03550096

AGONIST -> TARGET


					S3ABP24K72

ADB-FUBICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					H4APZ90T9U

CUMYL-PICA

AGONIST -> TARGET

Qualification:

Amount:


					ZV48MQ8R4L

ADB-PHETINACA

AGONIST -> TARGET

Amount:


					NG3U6O970A

5F-MDMB-PICA

AGONIST -> TARGET

Amount:


					SEL385TU4Y

JWH-080

AGONIST -> TARGET

Qualification:

Amount:


					3X4PHX3PGF

5-FLUORO PHENYL-PICA

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					CGYGFRRXKK

AM-4030

AGONIST -> TARGET

Qualification:

Amount:


					429P6KRK5A

PSB-SB-1202

AGONIST -> TARGET

Amount:


					VX6CM75L92

AB-FUBINACA 3-FLUOROBENZYL ISOMER

AGONIST -> TARGET

Amount:


					0ETP8M4H3E

AMB

AGONIST -> TARGET

Qualification:

Amount:


					UR5G69TJKH

ANANDAMIDE

AGONIST -> TARGET

Qualification:

IC50

Amount:


					HN6S9AD58B

5F-BZO-POXIZID

AGONIST -> TARGET

Comments:

Selectivity over the psychoactive CB1 receptor

Amount:


					8I5L034D55

ONTERNABEZ

AGONIST -> TARGET

Amount:


					U1A0765NDN

RCS-3

AGONIST -> TARGET

Qualification:

EC50

Amount:


					E6917946XH

STS-135

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Amount:


					7BN4RS63UV

5-FLUORO-CUMYL-PICA

AGONIST -> TARGET

Qualification:

Amount:


					K9H6459WGA

F-2201

AGONIST -> TARGET

Qualification:

Amount:


					B39WNG6743

THJ-018

AGONIST -> TARGET

Amount:


					PR85BBU47K

BIPICANA

AGONIST -> TARGET

Amount:


					5H31GI9502

WIN-55212-2

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					MM02A5A302

SDB-006

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					RIO7RT8MFX

MDMB-CHMCZCA

INHIBITOR -> TARGET

Amount:


					DTI87HQ3GT

5-FLUORO-AB-PICA

AGONIST -> TARGET

Amount:


					W4JEN9G47K

BZO-CHMOXIZID

AGONIST -> TARGET

Comments:

Emax 65% of CP55940

Qualification:

EC50

Amount:


					5AUY4Y2UPU

CID-16020046

LIGAND->TARGET


					4UP4SXX8BW

5F-SDB-006

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					SL4C60689M

ADB-CHMINACA

AGONIST -> TARGET

Qualification:

Amount:


					QCB63R9792

5-FLUORO-PB-22

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					VL9WD3Y83A

BZO-4en-POXIZID

AGONIST -> TARGET

Comments:

Emax=68.8

Amount:


					2N4O9L084N

NABILONE

AGONIST -> TARGET

Amount:


					3877T06H05

APP-CHMINACA

AGONIST -> TARGET

Qualification:

Amount:


					FD7BD1M9FY

5F-ADB

AGONIST -> TARGET

Qualification:

Amount:


					VL1I6P2DZ8

GW842166

AGONIST -> TARGET


					379WF7JJ36

WIN 54,461

INVERSE AGONIST->TARGET


					JS8UEW5PEV

AB-BICA

AGONIST -> TARGET

Amount:


					TB180WQ919

CBS-0550

AGONIST -> TARGET

Comments:

High selectivity for CB2 (CB1 IC50/CB2 IC50 = 1400),

Qualification:

EC50

Amount:


					E827UUV3S9

5F-CUMYL-PINACA

AGONIST -> TARGET

Amount:


					DLM851L3RD

AM-1241

AGONIST -> TARGET


					15Q075Q5LO

5-CHLORO-AB-PINACA

AGONIST -> TARGET

Qualification:

Amount:


					2FNW3VE8P9

BIM-018

AGONIST -> TARGET


					1TYA7HVP1B

UR-144

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					8G2SU6V9L7

NMP-7

AGONIST -> TARGET

Amount:


					QM6J8F29FE

PB-22

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					X83OI5CX2U

BZO-HEXOXIZID

AGONIST -> TARGET

Amount:


					2V3HAX6RM7

MMB-018

AGONIST -> TARGET

Amount:


					V3J3TQ3UPP

5F-CUMYL-P7AICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					8CZ9946YZ8

5F-ADB-PINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					744M0WHE80

5-FLUORO-AMB-PICA

AGONIST -> TARGET

Qualification:

Amount:


					522ZC95042

5-FLUORO-MN-18

AGONIST -> TARGET

Qualification:

Amount:


					O12H7VFU6P

LY-2828360

AGONIST -> TARGET


					BJ7SBQ2H5I

PX-1

AGONIST -> TARGET

Qualification:

Amount:


					TW71LSK9DG

APP-FUBINACA

AGONIST -> TARGET

Qualification:

Amount:


					Z6EXBVG316

MDMB-CHMINACA

AGONIST -> TARGET

Qualification:

Amount:


					P0248QCZ04

ADBICA

AGONIST -> TARGET

Amount:


					2P77W9B21O

SDB-004

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					P6H2AAY2GE

NESS-040C5

AGONIST -> TARGET

Qualification:

Amount:


					7AX37Z58VV

SERINOLAMIDE A

AGONIST -> TARGET

Amount:


					06QTR14ONW

JWH-307

AGONIST -> TARGET

Amount:


					H657DIA015

AB-001 (cannabinoid)

AGONIST -> TARGET

Amount:


					J8AEQ47LPQ

BZO-POXIZID

AGONIST -> TARGET

Comments:

Emax=68.8

Qualification:

EC50

Amount:


					U6SUE53VVY

AB-FUBICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					U9H280G9O7

5F-ADBICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					6R5GTC3QVB

CUMYL-THPINACA

AGONIST -> TARGET

Qualification:

Amount:


					UGG8YB299R

RoSMA-18-d6

AGONIST -> TARGET

Qualification:

Amount:


					Q7S86DY7UF

AMG-1

AGONIST -> TARGET

Amount:


					R23DTW852D

WIN 55212-2 H-3

RADIOLIGAND->TARGET

Qualification:

Amount:


					KSN77ZL0GD

RCS-2

AGONIST -> TARGET

Amount:


					X6JI7EA6EJ

MDMB-CHMICA

AGONIST -> TARGET

Qualification:

Amount:


					TY9AKI870R

AMB-FUBINACA

AGONIST -> TARGET

Qualification:

Amount:


					G391998J57

JWH-018

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					OU56JJP891

MA-CHMINACA

AGONIST -> TARGET

Qualification:

Amount:


					QG3J28E7L8

AB-CHMINACA

AGONIST -> TARGET

Qualification:

Amount:


					8D239QDW64

2-ARACHIDONOYLGLYCEROL

AGONIST -> TARGET

Comments:

The primary endogenous ligand for the CB2

Amount:


					U0Z5KO073G

FUB-JWH-018

AGONIST -> TARGET

Qualification:

Amount:


					5G2788GL5G

EG-018

AGONIST -> TARGET

Qualification:

Amount:


					DK24ID0BCL

5-FLUORO-AMP

AGONIST -> TARGET

Qualification:

Amount:


					6J3KC3S2PA

AB-PINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					3L83B2298V

5-FLUORO-AB-PINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					HKU510FH74

APICA

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					OO52S1U9ET

EAM-2201

AGONIST -> TARGET

Qualification:

Amount:


					2QB22HNV5B

N-(2S,3S)-3-ETHYL-3-DIDEMETHYL 5-FLUORO ADB-PINACA

AGONIST -> TARGET

Qualification:

Amount:


					M5H92FEG4W

FDU-NNE1

AGONIST -> TARGET

Qualification:

Amount:


					W6OZW1T05K

MEPIRAPIM

WEAK AGONIST->TARGET

Qualification:

Amount:


					64OSW0N4YB

5F-EMB-PINACA

AGONIST -> TARGET


					Y6911BZ2UL

RCS-4

AGONIST -> TARGET

Qualification:

EC50

Amount:


					I7PZF0KTFK

AB-FUBINACA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					4MC625LVID

UR-144 N-5-HYDROXYPENTYL

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					JYD20N5YL7

RCS-4 C4

AGONIST -> TARGET

Qualification:

EC50

Amount:


					7FVT9P642K

MN-24

AGONIST -> TARGET

Qualification:

Amount:


					TBJ0966F1O

AM-2201

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					HX8KIC8HSH

5F-SDB-002

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					BWQ0BJ2OGX

AB-PICA

AGONIST -> TARGET

Qualification:

EC50

Amount:


					NTR89S6ATP

[18F]RoSMA-18-d6

RADIOLIGAND->TARGET

Qualification:

Amount:


					3T22QDP4D9

5-FLUORO-MN-24

AGONIST -> TARGET

Qualification:

Amount:


					B3EM4XQ2QX

CBL-018

AGONIST -> TARGET

Amount:


					FP569278V0

5F-SDB-004

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					60V195Q93I

SDB-003

AGONIST -> TARGET

Comments:

Mouse AtT-20 neuroblastoma cells stably transfected with human CB2

Qualification:

EC50

Amount:


					Z5N9WL7X4P

MO-CHMINAKA

AGONIST -> TARGET

Qualification:

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL