U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 18:39:44 GMT 2025
Edited
by admin
on Tue Apr 01 18:39:44 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
SKEU5X23RI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CANNABINOID RECEPTOR TYPE 2
Preferred Name English
CANNABINOID RECEPTOR 2
Common Name English
CB2
Common Name English
Code System Code Type Description
UNIPROT
P34972
Created by admin on Tue Apr 01 18:39:45 GMT 2025 , Edited by admin on Tue Apr 01 18:39:45 GMT 2025
PRIMARY
FDA UNII
SKEU5X23RI
Created by admin on Tue Apr 01 18:39:45 GMT 2025 , Edited by admin on Tue Apr 01 18:39:45 GMT 2025
PRIMARY
PHAROS
P34972
Created by admin on Tue Apr 01 18:39:45 GMT 2025 , Edited by admin on Tue Apr 01 18:39:45 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_11
Related Record Type Details
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Selectivity of around 220 times for CB2 over CB1 receptors.
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
A potent agonist
AGONIST -> TARGET
IC50
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
INVERSE AGONIST->TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Strong agonist
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
MN-25 (UR-12) acts as a reasonably selective agonist of peripheral cannabinoid receptors. It has moderate affinity for CB2 receptors with a Ki of 11 nM.
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
EC50
INVERSE AGONIST->TARGET
?69% of basal activity
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
IC50
AGONIST -> TARGET
Selectivity over the psychoactive CB1 receptor
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Emax 65% of CP55940
EC50
LIGAND->TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
Emax=68.8
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
INVERSE AGONIST->TARGET
AGONIST -> TARGET
AGONIST -> TARGET
High selectivity for CB2 (CB1 IC50/CB2 IC50 = 1400),
EC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Emax=68.8
EC50
RADIOLIGAND->TARGET
Highly selective. Binding to the CB1 receptor KihCB1 >1000 nM
BINDING
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
RADIOLIGAND->TARGET
Kd
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
The primary endogenous ligand for the CB2
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Ki
WEAK AGONIST->TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
EC50
RADIOLIGAND->TARGET
Ki
AGONIST -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
AGONIST -> TARGET
Ki

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_335] [1_336] [1_352] DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_338] THREONINE PHOSPHATE 3L4WX7B1EI
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL