Details
Stereochemistry | ACHIRAL |
Molecular Formula | C24H23NO |
Molecular Weight | 341.4464 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCn1cc(c2ccccc21)C(=O)c3cccc4ccccc43
InChI
InChIKey=JDNLPKCAXICMBW-UHFFFAOYSA-N
InChI=1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3
Molecular Formula | C24H23NO |
Molecular Weight | 341.4464 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionCurator's Comment:: description was created based on several sources, including:
https://psychonautwiki.org/wiki/JWH-018 | https://en.wikipedia.org/wiki/JWH-018
Curator's Comment:: description was created based on several sources, including:
https://psychonautwiki.org/wiki/JWH-018 | https://en.wikipedia.org/wiki/JWH-018
JWH-018 is a full agonist synthetic cannabinoid with a high binding affinity to CB1 and CB2 cannabinoid receptors. JWH-018 has not been used in therapy. Many of the risks linked to cannabis use are also present in the case of JWH-018, among them complications in patients suffering from cardiovascular diseases and triggering of acute psychosis. JWH-018 has not been used in therapy. Studies in mice showed anti-inflammatory and cancer chemopreventive properties of JWH-018.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL218 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10940540 |
9.0 nM [Ki] | ||
Target ID: CHEMBL253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10940540 |
2.94 nM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
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Preventing | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Discriminative stimulus functions of methanandamide and delta(9)-THC in rats: tests with aminoalkylindoles (WIN55,212-2 and AM678) and ethanol. | 2010 Jan |
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Detection of JWH-018 metabolites in smoking mixture post-administration urine. | 2010 Jul 15 |
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JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist. | 2010 Jun |
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Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography-tandem mass spectrometry. | 2010 Oct 1 |
Patents
Sample Use Guides
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 10:35:18 UTC 2021
by
admin
on
Sat Jun 26 10:35:18 UTC 2021
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Record UNII |
G391998J57
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Record Status |
Validated (UNII)
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Record Version |
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DEA NO. |
7118
Created by
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209414-07-3
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G391998J57
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C552597
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JWH-018
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209414-07-3
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7998
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10382701
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TARGET -> AGONIST |
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
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