ADB-FUBINACA

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H23FN4O2
Molecular Weight	382.4321
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)[C@@]([H])(C(=N)O)NC(=O)c1c2ccccc2n(Cc3ccc(cc3)F)n1

InChI

InChIKey=ZSSGCSINPVBLQD-GOSISDBHSA-N

InChI=1S/C21H23FN4O2/c1-21(2,3)18(19(23)27)24-20(28)17-15-6-4-5-7-16(15)26(25-17)12-13-8-10-14(22)11-9-13/h4-11,18H,12H2,1-3H3,(H2,23,27)(H,24,28)/t18-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C21H23FN4O2
Molecular Weight	382.4321
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26134475 | https://www.ncbi.nlm.nih.gov/pubmed/28425681 | https://www.ncbi.nlm.nih.gov/pubmed/28262132

N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide [ADB-FUBINACA] is a synthetic cannabinoid, a Schedule I drug. ADB-FUBINACA acts as a high potency agonist of cannabinoid CB1 receptor. The compound considered to be a component of illicit smoking mixtures "spice".

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cannabinoid CB1 receptor 80 Target ID: CHEMBL218 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26134475	Agonist 2456		0.36 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown

PubMed

Title	Date	PubMed
UPLC/ESI-MS/MS-based determination of metabolism of several new illicit drugs, ADB-FUBINACA, AB-FUBINACA, AB-PINACA, QUPIC, 5F-QUPIC and α-PVT, by human liver microsome.	2014 Jun	24861751
Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA.	2015 Sep 16	26134475
Schedules of Controlled Substances: Temporary Placement of Six Synthetic Cannabinoids (5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-CHMICA and MDMB-FUBINACA) into Schedule I. Temporary Scheduling Order.	2017 Apr 10	28425681

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Jun 25 20:40:15 UTC 2021` Edited by `admin` on `Fri Jun 25 20:40:15 UTC 2021`
Record UNII	05235E1S2O
Record Status	`Validated (UNII)`
Record Version