U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C24H24N2O
Molecular Weight 356.4611
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MN-24

SMILES

CCCCCn1cc(c2ccccc21)C(=Nc3cccc4ccccc43)O

InChI

InChIKey=GWCQNKRMTGVYIZ-UHFFFAOYSA-N
InChI=1S/C24H24N2O/c1-2-3-8-16-26-17-21(20-13-6-7-15-23(20)26)24(27)25-22-14-9-11-18-10-4-5-12-19(18)22/h4-7,9-15,17H,2-3,8,16H2,1H3,(H,25,27)

HIDE SMILES / InChI

Molecular Formula C24H24N2O
Molecular Weight 356.4611
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
10.0 nM [EC50]
100.0 nM [Ki]
Substance Class Chemical
Created
by admin
on Sat Jun 26 12:23:03 UTC 2021
Edited
by admin
on Sat Jun 26 12:23:03 UTC 2021
Record UNII
7FVT9P642K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MN-24
Common Name English
NNE1
Common Name English
AM-6527
Code English
1H-INDOLE-3-CARBOXAMIDE, N-1-NAPHTHALENYL-1-PENTYL-
Systematic Name English
NNEI
Code English
N-(NAPHTHALEN-1-YL)-1-PENTYL-1H-INDOLE-3-CARBOXAMIDE
Systematic Name English
Code System Code Type Description
CAS
1338925-11-3
Created by admin on Sat Jun 26 12:23:03 UTC 2021 , Edited by admin on Sat Jun 26 12:23:03 UTC 2021
PRIMARY
EPA CompTox
1338925-11-3
Created by admin on Sat Jun 26 12:23:03 UTC 2021 , Edited by admin on Sat Jun 26 12:23:03 UTC 2021
PRIMARY
PUBCHEM
54752945
Created by admin on Sat Jun 26 12:23:03 UTC 2021 , Edited by admin on Sat Jun 26 12:23:03 UTC 2021
PRIMARY
WIKIPEDIA
NNE1
Created by admin on Sat Jun 26 12:23:03 UTC 2021 , Edited by admin on Sat Jun 26 12:23:03 UTC 2021
PRIMARY NNE1 (also known as NNEI, MN-24 and AM-6527) is an indole-based synthetic cannabinoid, representing a molecular hybrid of APICA and JWH-018. It was invented by Abbott and has a CB1 receptor pEC50 of 8.9 (i.e. EC50 of approximately 1nM) with around 80x selectivity over the related CB2 receptor. It is suspected that metabolic hydrolysis of the amide group of NNE1 may release 1-naphthylamine, a known carcinogen, given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, and NNE1 was banned in New Zealand in 2012 as a temporary class drug to stop it being used as an ingredient in then-legal synthetic cannabis products.(3) NNE1 was subsequently found to be responsible for the death of a man in Japan in 2014.
FDA UNII
7FVT9P642K
Created by admin on Sat Jun 26 12:23:03 UTC 2021 , Edited by admin on Sat Jun 26 12:23:03 UTC 2021
PRIMARY
MANUFACTURER PRODUCT INFORMATION
MN-24
Created by admin on Sat Jun 26 12:23:03 UTC 2021 , Edited by admin on Sat Jun 26 12:23:03 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
Ki
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY