MN-24

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NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H24N2O
Molecular Weight	356.4602
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MN-24

Structure Search

SMILES

CCCCCN1C=C(C(=O)NC2=C3C=CC=CC3=CC=C2)C4=C1C=CC=C4

InChI

InChIKey=GWCQNKRMTGVYIZ-UHFFFAOYSA-N

InChI=1S/C24H24N2O/c1-2-3-8-16-26-17-21(20-13-6-7-15-23(20)26)24(27)25-22-14-9-11-18-10-4-5-12-19(18)22/h4-7,9-15,17H,2-3,8,16H2,1H3,(H,25,27)

HIDE SMILES / InChI

Molecular Formula	C24H24N2O
Molecular Weight	356.4602
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Cannabinoid CB1 receptor 85 Target ID: CHEMBL218 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21885167	Agonist 2678		10.0 nM [EC50]
Cannabinoid CB2 receptor 71 Target ID: CHEMBL253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21885167	Agonist 2678		100.0 nM [Ki]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:25:48 GMT 2023` Edited by `admin` on `Sat Dec 16 10:25:48 GMT 2023`
Record UNII	7FVT9P642K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MN-24

Common Name

English

NNE1

Common Name

English

AM-6527

Code

English

1H-INDOLE-3-CARBOXAMIDE, N-1-NAPHTHALENYL-1-PENTYL-

Systematic Name

English

NNEI

Code

English

N-(NAPHTHALEN-1-YL)-1-PENTYL-1H-INDOLE-3-CARBOXAMIDE

Systematic Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-NNE1

Created by admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023

Code System Code Type Description

CAS

1338925-11-3

Created by admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023

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EPA CompTox

DTXSID50716467

Created by admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023

PRIMARY

PUBCHEM

54752945

Created by admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023

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WIKIPEDIA

NNE1

Created by admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023

PRIMARY

NNE1 (also known as NNEI, MN-24 and AM-6527) is an indole-based synthetic cannabinoid, representing a molecular hybrid of APICA and JWH-018. It was invented by Abbott and has a CB1 receptor pEC50 of 8.9 (i.e. EC50 of approximately 1nM) with around 80x selectivity over the related CB2 receptor. It is suspected that metabolic hydrolysis of the amide group of NNE1 may release 1-naphthylamine, a known carcinogen, given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, and NNE1 was banned in New Zealand in 2012 as a temporary class drug to stop it being used as an ingredient in then-legal synthetic cannabis products.(3) NNE1 was subsequently found to be responsible for the death of a man in Japan in 2014.

FDA UNII

7FVT9P642K

Created by admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023

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MANUFACTURER PRODUCT INFORMATION

MN-24

Created by admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023

PRIMARY

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ACTIVE MOIETY