ROSONABANT

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H21Cl3N4O
Molecular Weight	451.777
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(C=C1)C2CC(=NN2C3=C(Cl)C=C(Cl)C=C3)C(=O)NN4CCCCC4

InChI

InChIKey=WMMMJGKFKKBRQR-UHFFFAOYSA-N

InChI=1S/C21H21Cl3N4O/c22-15-6-4-14(5-7-15)20-13-18(21(29)26-27-10-2-1-3-11-27)25-28(20)19-9-8-16(23)12-17(19)24/h4-9,12,20H,1-3,10-11,13H2,(H,26,29)

HIDE SMILES / InChI

Molecular Formula	C21H21Cl3N4O
Molecular Weight	451.777
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19249987 | https://www.ncbi.nlm.nih.gov/pubmed/20002080 | https://books.google.com/books?id=YO3BUp3nicMC&pg=PA325#v=onepage&q=e-6776%20&f=false

Rosonabant (E-6776) is a CB1-receptor antagonist that has appetite suppressant activity and was under development for the treatment of obesity. This preclinical anti-obesity drug shows activity that is similar to romonabant, a drug that was withdrawn from the European market due to severe side effects such as nausea, depression and suicidal ideations. Drug development of rosonabant has subsequently been halted.

Originator

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:17:10 UTC 2023` Edited by `admin` on `Fri Dec 15 17:17:10 UTC 2023`
Record UNII	7X5RY2T485
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ROSONABANT

Official Name

English

(5RS)-5-(4-CHLOROPHENYL)-1-(2,4-DICHLOROPHENYL)-N-(PIPERIDIN-1-YL)-4,5-DIHYDRO-1H-PYRAZOLE-3-CARBOXAMIDE

Systematic Name

English

Rosonabant [WHO-DD]

Common Name

English

rosonabant [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29728