Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C24H40O3 |
| Molecular Weight | 376.5726 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCC(C)(C)C1=CC(O)=C(C=C1)[C@@H]2C[C@H](O)CC[C@H]2CCCO
InChI
InChIKey=YNZFFALZMRAPHQ-SYYKKAFVSA-N
InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1
| Molecular Formula | C24H40O3 |
| Molecular Weight | 376.5726 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones. | 1992 Nov |
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| Molecular characterization of a peripheral receptor for cannabinoids. | 1993 Sep 2 |
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| Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. | 1995 Dec 1 |
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| Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells. | 1995 Jun 9 |
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| Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. | 1995 Sep |
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| Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. | 1996 Jun 7 |
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| Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A. | 1996 Mar 22 |
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| Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. | 1996 May 1 |
|
| Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. | 1996 Sep |
|
| Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors. | 1997 Jun |
|
| Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain. | 1998 Mar 30 |
|
| Effect of (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol (CP55,940) on intracellular Ca2+ levels in human osteosarcoma cells. | 2002 Sep 30 |
|
| Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor. | 2003 Feb 7 |
|
| Cannabinoid receptor-independent inhibition by cannabinoid agonists of the peripheral 5-HT3 receptor-mediated von Bezold-Jarisch reflex. | 2003 Mar |
|
| Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease. | 2003 Mar |
|
| Pre-exposure to the cannabinoid receptor agonist CP 55940 enhances morphine behavioral sensitization and alters morphine self-administration in Lewis rats. | 2003 Mar 28 |
|
| 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. | 2004 Apr |
|
| Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats. | 2004 Dec |
|
| Differential effects of CB1 and opioid agonists on two populations of adult rat dorsal root ganglion neurons. | 2004 Feb 18 |
|
| Spontaneous cannabinoid withdrawal produces a differential time-related responsiveness in cannabinoid CB1 receptor gene expression in the mouse brain. | 2004 Mar |
|
| Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala. | 2005 Mar |
|
| Clozapine decreases [3H] CP 55940 binding to the cannabinoid 1 receptor in the rat nucleus accumbens. | 2005 May |
|
| Allosteric modulation of the cannabinoid CB1 receptor. | 2005 Nov |
|
| Indirect CB2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids. | 2005 Nov |
|
| The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-55940). | 2005 Sep |
|
| Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons. | 2005 Sep 14 |
|
| Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol. | 2006 Dec |
|
| Effects of exogenous and endogenous cannabinoids on GABAergic neurotransmission between the caudate-putamen and the globus pallidus in the mouse. | 2006 Feb |
|
| F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist. | 2006 Feb 15 |
|
| In silico patent searching reveals a new cannabinoid receptor. | 2006 Jan |
|
| Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling. | 2006 Jul |
|
| Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats. | 2006 Jul 1 |
|
| Systemic effect of cannabinoids on the spontaneous firing rate of locus coeruleus neurons in rats. | 2006 Mar 18 |
|
| Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells. | 2007 Aug |
|
| The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats. | 2007 Dec |
|
| The orphan receptor GPR55 is a novel cannabinoid receptor. | 2007 Dec |
|
| Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors. | 2007 Feb |
|
| Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. | 2007 Jun 22 |
|
| Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line. | 2007 Sep |
|
| Chronologically overlapping occurrences of nicotine-induced anxiety- and depression-related behavioral symptoms: effects of anxiolytic and cannabinoid drugs. | 2007 Sep 18 |
|
| Cannabinoids and hamster circadian activity rhythms. | 2008 Jul 30 |
|
| TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. | 2008 Jun 11 |
|
| Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB1 receptor. | 2008 Sep |
|
| Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands. | 2011 Oct 1 |
|
| Cannabinoid-induced enhanced interaction and protein levels of serotonin 5-HT(2A) and dopamine D₂ receptors in rat prefrontal cortex. | 2012 Oct |
|
| Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats. | 2013 Aug 26 |
|
| Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors. | 2013 Feb |
|
| Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. | 2013 Jun 1 |
|
| Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5-HT(2A)) receptor activity via ERK1/2 signaling. | 2013 Mar |
|
| Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death. | 2014 Jan 1 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:52:29 GMT 2025
by
admin
on
Mon Mar 31 22:52:29 GMT 2025
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| Record UNII |
KFY70972J5
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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WIKIPEDIA |
Designer-drugs-(-)-CP-55940
Created by
admin on Mon Mar 31 22:52:29 GMT 2025 , Edited by admin on Mon Mar 31 22:52:29 GMT 2025
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| Code System | Code | Type | Description | ||
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KFY70972J5
Created by
admin on Mon Mar 31 22:52:29 GMT 2025 , Edited by admin on Mon Mar 31 22:52:29 GMT 2025
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CP 55,940
Created by
admin on Mon Mar 31 22:52:29 GMT 2025 , Edited by admin on Mon Mar 31 22:52:29 GMT 2025
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DTXSID80875516
Created by
admin on Mon Mar 31 22:52:29 GMT 2025 , Edited by admin on Mon Mar 31 22:52:29 GMT 2025
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104895
Created by
admin on Mon Mar 31 22:52:29 GMT 2025 , Edited by admin on Mon Mar 31 22:52:29 GMT 2025
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83002-04-4
Created by
admin on Mon Mar 31 22:52:29 GMT 2025 , Edited by admin on Mon Mar 31 22:52:29 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> INHIBITOR |
BINDING
IC50
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TARGET -> AGONIST |
Strong agonist
EC50
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TARGET -> AGONIST |
Strong agonist
EC50
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LABELED -> NON-LABELED |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
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