Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H21Cl2N5O2 |
| Molecular Weight | 469.352 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[11CH3]OC1=CC=C(C=C1)C2=C(C#N)C(=NN2C3=C(Cl)C=C(Cl)C=C3)C(=O)NN4CCCCC4
InChI
InChIKey=MCNQUWLLXZZZAC-BJUDXGSMSA-N
InChI=1S/C23H21Cl2N5O2/c1-32-17-8-5-15(6-9-17)22-18(14-26)21(23(31)28-29-11-3-2-4-12-29)27-30(22)20-10-7-16(24)13-19(20)25/h5-10,13H,2-4,11-12H2,1H3,(H,28,31)/i1-1
| Molecular Formula | C23H21Cl2N5O2 |
| Molecular Weight | 469.352 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
11C-JHU75528 (also known as 11C-OMAR) is a radiotracer with suitable imaging properties for quantification of cannabinoid receptor, CB1R in the human brain. 11C-JHU75528 is participating in an ongoing phase I clinical trial to examine whether the use of cannabis alters CB1R availability in females and if the severity of cannabis withdrawal is correlated with CB1 receptor availability.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:32:56 UTC 2023
by
admin
on
Sat Dec 16 11:32:56 UTC 2023
|
| Record UNII |
8YHH21923L
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
8YHH21923L
Created by
admin on Sat Dec 16 11:32:56 UTC 2023 , Edited by admin on Sat Dec 16 11:32:56 UTC 2023
|
PRIMARY | |||
|
DB14902
Created by
admin on Sat Dec 16 11:32:56 UTC 2023 , Edited by admin on Sat Dec 16 11:32:56 UTC 2023
|
PRIMARY | |||
|
11963742
Created by
admin on Sat Dec 16 11:32:56 UTC 2023 , Edited by admin on Sat Dec 16 11:32:56 UTC 2023
|
PRIMARY | |||
|
942063-86-7
Created by
admin on Sat Dec 16 11:32:56 UTC 2023 , Edited by admin on Sat Dec 16 11:32:56 UTC 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET->RADIOLIGAND |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
11C-JHU75528 readily entered the mouse and baboon brain and specifically and selectively labeled cerebral CB1 receptors. The ratio of striatum to brain stem in mice and the binding potential (BP) in the baboon putamen were 3.4 and 1.321.5, respectively. The specific binding of 11C-JHU75528 in vivo was blocked by preinjection of nonlabeled JHU75528. Administration of rimonabant (1 mg/kg, intravenously) also blocked the specific binding of 11C-JHU75528 in the mouse and baboon brain, whereas various central noncannabinoid drugs did not significantly reduce the 11C-JHU75528 binding in the mouse brain. 11C-JHU75528 formed several hydrophilic metabolites, but only a minute fraction of metabolic radioactivity penetrated the BBB.
|
