U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ABSOLUTE
Molecular Formula C23H26FN3O2
Molecular Weight 395.4698
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PX-1

SMILES

NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=CN(CCCCCF)C3=C2C=CC=C3

InChI

InChIKey=DDVANTXQCRMRFF-FQEVSTJZSA-N
InChI=1S/C23H26FN3O2/c24-13-7-2-8-14-27-16-19(18-11-5-6-12-21(18)27)23(29)26-20(22(25)28)15-17-9-3-1-4-10-17/h1,3-6,9-12,16,20H,2,7-8,13-15H2,(H2,25,28)(H,26,29)/t20-/m0/s1

HIDE SMILES / InChI

Molecular Formula C23H26FN3O2
Molecular Weight 395.4698
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
83.2 nM [EC50]
PubMed

PubMed

TitleDatePubMed
Comprehensive investigation on synthetic cannabinoids: Metabolic behavior and potency testing, using 5F-APP-PICA and AMB-FUBINACA as model compounds.
2019 Sep
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:22:46 GMT 2025
Edited
by admin
on Mon Mar 31 23:22:46 GMT 2025
Record UNII
BJ7SBQ2H5I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SRF-30
Preferred Name English
PX-1
Code English
(S)-N-(1-AMINO-1-OXO-3-PHENYLPROPAN-2-YL)-1-(5-FLUOROPENTYL)-1H-INDOLE-3-CARBOXAMIDE
Systematic Name English
1H-INDOLE-3-CARBOXAMIDE, N-((1S)-2-AMINO-2-OXO-1-(PHENYLMETHYL)ETHYL)-1-(5-FLUOROPENTYL)-
Systematic Name English
5-FLUORO APP-PICA
Common Name English
N-((1S)-2-AMINO-1-BENZYL-2-OXO-ETHYL)-1-(5-FLUOROPENTYL)INDOLE-3-CARBOXAMIDE
Systematic Name English
5F-APP-PICA
Common Name English
Classification Tree Code System Code
WIKIPEDIA Designer-drugs-PX-1
Created by admin on Mon Mar 31 23:22:46 GMT 2025 , Edited by admin on Mon Mar 31 23:22:46 GMT 2025
Code System Code Type Description
WIKIPEDIA
PX-1
Created by admin on Mon Mar 31 23:22:46 GMT 2025 , Edited by admin on Mon Mar 31 23:22:46 GMT 2025
PRIMARY PX-1 (also known as 5F-APP-PICA and SRF-30) is an indole-based synthetic cannabinoid that has been sold online as a designer drug. Sweden's public health agency suggested classifying PX-1 as hazardous substance on November 10, 2014. PX-1 is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.
CAS
2221100-71-4
Created by admin on Mon Mar 31 23:22:46 GMT 2025 , Edited by admin on Mon Mar 31 23:22:46 GMT 2025
PRIMARY
MANUFACTURER PRODUCT INFORMATION
5F-APP-PICA
Created by admin on Mon Mar 31 23:22:46 GMT 2025 , Edited by admin on Mon Mar 31 23:22:46 GMT 2025
PRIMARY AM2201 (Item No. 10707) is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, respectively.1 PX 1 is a derivative of AM2201 with a PINACA-like upper chain where the isopropyl group has been replaced with a benzyl group. The physiological and toxicological properties of this compound have not been determined.
EPA CompTox
DTXSID101016916
Created by admin on Mon Mar 31 23:22:46 GMT 2025 , Edited by admin on Mon Mar 31 23:22:46 GMT 2025
PRIMARY
PUBCHEM
125181260
Created by admin on Mon Mar 31 23:22:46 GMT 2025 , Edited by admin on Mon Mar 31 23:22:46 GMT 2025
PRIMARY
WEB RESOURCE
5F-APP-PICA
Created by admin on Mon Mar 31 23:22:46 GMT 2025 , Edited by admin on Mon Mar 31 23:22:46 GMT 2025
PRIMARY PX-1 is also known as 5F-APP-PICA, PX-2 as 5F-APP-PINACA.
FDA UNII
BJ7SBQ2H5I
Created by admin on Mon Mar 31 23:22:46 GMT 2025 , Edited by admin on Mon Mar 31 23:22:46 GMT 2025
PRIMARY
Related Record Type Details
TARGET -> AGONIST
Ki
TARGET -> AGONIST
Ki
Related Record Type Details
ACTIVE MOIETY