AM-281

CC1=C(N(N=C1C(=O)NN2CCOCC2)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(I)C=C4

InChIKey=AJFFBPZYXRNAIC-UHFFFAOYSA-N

InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Cannabinoid CB1 receptor 85 Target ID: CHEMBL218 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18511157	Antagonist 2778		422.0 nM [Ki]
Cannabinoid CB2 receptor 71 Target ID: CHEMBL253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19278853	Inverse Agonist 80		4.87 µM [Ki]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 13:43:02 GMT 2023` Edited by `admin` on `Sat Dec 16 13:43:02 GMT 2023`
Record UNII	SBP4A4DYH2
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

AM-281

Common Name

English

1H-PYRAZOLE-3-CARBOXAMIDE, 1-(2,4-DICHLOROPHENYL)-5-(4-IODOPHENYL)-4-METHYL-N-4-MORPHOLINYL-

Systematic Name

English

1-(2,4-DICHLOROPHENYL)-5-(4-IODOPHENYL)-4-METHYL-N-4-MORPHOLINYL-1H-PYRAZOLE-3-CARBOXAMIDE

Systematic Name

English

AM281

Common Name

English

N-(MORPHOLIN-4-YL)-1-(2,4-DICHLOROPHENYL)-5-(4-IODOPHENYL)-4-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

SBP4A4DYH2