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Details

Stereochemistry ACHIRAL
Molecular Formula C21H19Cl2IN4O2
Molecular Weight 557.212
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AM-281

SMILES

CC1=C(N(N=C1C(=O)NN2CCOCC2)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(I)C=C4

InChI

InChIKey=AJFFBPZYXRNAIC-UHFFFAOYSA-N
InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)

HIDE SMILES / InChI

Molecular Formula C21H19Cl2IN4O2
Molecular Weight 557.212
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
422.0 nM [Ki]
4.87 µM [Ki]
Substance Class Chemical
Created
by admin
on Sat Dec 16 13:43:02 GMT 2023
Edited
by admin
on Sat Dec 16 13:43:02 GMT 2023
Record UNII
SBP4A4DYH2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AM-281
Common Name English
1H-PYRAZOLE-3-CARBOXAMIDE, 1-(2,4-DICHLOROPHENYL)-5-(4-IODOPHENYL)-4-METHYL-N-4-MORPHOLINYL-
Systematic Name English
1-(2,4-DICHLOROPHENYL)-5-(4-IODOPHENYL)-4-METHYL-N-4-MORPHOLINYL-1H-PYRAZOLE-3-CARBOXAMIDE
Systematic Name English
AM281
Common Name English
N-(MORPHOLIN-4-YL)-1-(2,4-DICHLOROPHENYL)-5-(4-IODOPHENYL)-4-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE
Systematic Name English
Code System Code Type Description
FDA UNII
SBP4A4DYH2
Created by admin on Sat Dec 16 13:43:02 GMT 2023 , Edited by admin on Sat Dec 16 13:43:02 GMT 2023
PRIMARY
EPA CompTox
DTXSID601122269
Created by admin on Sat Dec 16 13:43:02 GMT 2023 , Edited by admin on Sat Dec 16 13:43:02 GMT 2023
PRIMARY
PUBCHEM
4302962
Created by admin on Sat Dec 16 13:43:02 GMT 2023 , Edited by admin on Sat Dec 16 13:43:02 GMT 2023
PRIMARY
CAS
202463-68-1
Created by admin on Sat Dec 16 13:43:02 GMT 2023 , Edited by admin on Sat Dec 16 13:43:02 GMT 2023
PRIMARY
WIKIPEDIA
List of AM cannabinoids
Created by admin on Sat Dec 16 13:43:02 GMT 2023 , Edited by admin on Sat Dec 16 13:43:02 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
AM281 is a selective CB1 receptor antagonis
BINDING
IC50