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Details

Stereochemistry ABSOLUTE
Molecular Formula C20H21F3O5S
Molecular Weight 430.4398
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of KN-387271

SMILES

c1cc2C[C@]([H])(Cc2c(c1)Oc3cccc(c3)OS(=O)(=O)CCCC(F)(F)F)CO

InChI

InChIKey=XJURALZPEJKKOV-CQSZACIVSA-N
InChI=1S/C20H21F3O5S/c21-20(22,23)8-3-9-29(25,26)28-17-6-2-5-16(12-17)27-19-7-1-4-15-10-14(13-24)11-18(15)19/h1-2,4-7,12,14,24H,3,8-11,13H2/t14-/m1/s1

HIDE SMILES / InChI

Molecular Formula C20H21F3O5S
Molecular Weight 430.4398
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Jun 26 00:09:12 UTC 2021
Edited
by admin
on Sat Jun 26 00:09:12 UTC 2021
Record UNII
SRX4T6TMUS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
KN-387271
Common Name English
1-BUTANESULFONIC ACID, 4,4,4-TRIFLUORO-, 3-(((2R)-2,3-DIHYDRO-2-(HYDROXYMETHYL)-1H-INDEN-4-YL)OXY)PHENYL ESTER
Systematic Name English
BAY-38-7271
Common Name English
KN 38-7271
Common Name English
(-)-(R)-3-(2-HYDROXYMETHYLINDANYL-4-OXY)PHENYL-4,4,4-TRIFLUOROBUTYL-1-SULFONATE
Common Name English
(-)-BAY-38-7271
Common Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/08/560
Created by admin on Sat Jun 26 00:09:12 UTC 2021 , Edited by admin on Sat Jun 26 00:09:12 UTC 2021
Code System Code Type Description
PUBCHEM
9845561
Created by admin on Sat Jun 26 00:09:12 UTC 2021 , Edited by admin on Sat Jun 26 00:09:12 UTC 2021
PRIMARY
FDA UNII
SRX4T6TMUS
Created by admin on Sat Jun 26 00:09:12 UTC 2021 , Edited by admin on Sat Jun 26 00:09:12 UTC 2021
PRIMARY
WIKIPEDIA
BAY 38-7271
Created by admin on Sat Jun 26 00:09:12 UTC 2021 , Edited by admin on Sat Jun 26 00:09:12 UTC 2021
PRIMARY Originally synthesized by chemist Wayne E. Kenney, BAY 38-7271 (KN 38-7271) is a drug which is a cannabinoid receptor agonist developed by Bayer AG. It has analgesic and neuroprotective effects and is used in scientific research, with proposed uses in the treatment of traumatic brain injury. It is a full agonist with around the same potency as CP 55,940 in animal studies, and has fairly high affinity for both CB1 and CB2 receptors, with Ki values of 2.91nM at CB1 and 4.24nM at CB2. It has now been licensed to KeyNeurotek Pharmaceuticals for clinical development, and is currently in Phase II trials. But its development appears stopped.
CAS
212188-60-8
Created by admin on Sat Jun 26 00:09:12 UTC 2021 , Edited by admin on Sat Jun 26 00:09:12 UTC 2021
PRIMARY
MANUFACTURER PRODUCT INFORMATION
BAY-38-7271
Created by admin on Sat Jun 26 00:09:12 UTC 2021 , Edited by admin on Sat Jun 26 00:09:12 UTC 2021
PRIMARY BAY 38-7271 (KN 38-7271) CAS: 212188-60-8
EVMPD
SUB195628
Created by admin on Sat Jun 26 00:09:12 UTC 2021 , Edited by admin on Sat Jun 26 00:09:12 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY