Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H22N2O2 |
| Molecular Weight | 358.433 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCN1C=C(C(=O)OC2=C3N=CC=CC3=CC=C2)C4=C1C=CC=C4
InChI
InChIKey=ZAVGICCEAOUWFM-UHFFFAOYSA-N
InChI=1S/C23H22N2O2/c1-2-3-6-15-25-16-19(18-11-4-5-12-20(18)25)23(26)27-21-13-7-9-17-10-8-14-24-22(17)21/h4-5,7-14,16H,2-3,6,15H2,1H3
| Molecular Formula | C23H22N2O2 |
| Molecular Weight | 358.433 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/27632803
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/27632803
PB-22, a recreational “designer drugs”, is a cannabimimetic agent, it is a full agonist of cannabinoid receptors. PB-22 has an EC50 of 5.1 nM for human CB1 receptors, and 37 nM for human CB2 receptors. PB-22 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity. PB-22 was designated as a Schedule I controlled substance in the United States.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135. | 2015 Aug 19 |
|
| Schedules of Controlled Substances: Placement of PB-22, 5F-PB-22, AB-FUBINACA and ADB-PINACA into Schedule I. Final rule. | 2016 Sep 6 |
Patents
Sample Use Guides
PB-22 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg intraperitoneally
Route of Administration:
Intraperitoneal
| Substance Class |
Chemical
Created
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admin
on
Edited
Thu Jul 06 08:29:51 UTC 2023
by
admin
on
Thu Jul 06 08:29:51 UTC 2023
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| Record UNII |
QM6J8F29FE
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| Record Status |
Validated (UNII)
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DEA NO. |
7222
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WIKIPEDIA |
Designer-drugs-PB-22
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1400742-17-7
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DTXSID70856177
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QM6J8F29FE
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PB-22
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71604304
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| Related Record | Type | Details | ||
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TARGET -> AGONIST |
Mouse AtT-20 neuroblastoma cells stably transfected with human CB1
EC50
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TARGET -> AGONIST |
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
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ACTIVE MOIETY |
