FUBIMINA

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H21FN2O
Molecular Weight	360.424
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of FUBIMINA

Structure Search

SMILES

FCCCCCN1C2=CC=CC=C2N=C1C(=O)C3=CC=CC4=CC=CC=C34

InChI

InChIKey=KUESSZMROAFKQJ-UHFFFAOYSA-N

InChI=1S/C23H21FN2O/c24-15-6-1-7-16-26-21-14-5-4-13-20(21)25-23(26)22(27)19-12-8-10-17-9-2-3-11-18(17)19/h2-5,8-14H,1,6-7,15-16H2

HIDE SMILES / InChI

Molecular Formula	C23H21FN2O
Molecular Weight	360.424
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Cannabinoid CB1 receptor 85 Target ID: CHEMBL218 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26105953	Agonist 2678		296.1 nM [Ki]
Cannabinoid CB2 receptor 71 Target ID: CHEMBL253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26105953	Agonist 2678		23.45 nM [Ki]

PubMed

PubMed

Title	Date	PubMed
AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice.	2015 Sep	26105953
Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes.	2016	27547265

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:37:33 GMT 2023` Edited by `admin` on `Sat Dec 16 10:37:33 GMT 2023`
Record UNII	U96GD9R3UZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FUBIMINA

Common Name

English

BZ-2201

Code

English

FTHJ

Common Name

English

(1-(5-FLUOROPENTYL)BENZIMIDAZOL-2-YL)-(1-NAPHTHYL)METHANONE

Systematic Name

English

(1-(5-FLUOROPENTYL)-1H-BENZO(D)IMIDAZOL-2-YL)(NAPHTHALEN-1-YL)METHANONE

Systematic Name

English

BIM-2201

Code

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-FUBIMINA

Created by admin on Sat Dec 16 10:37:33 GMT 2023 , Edited by admin on Sat Dec 16 10:37:33 GMT 2023

Code System Code Type Description

PUBCHEM

124519316

Created by admin on Sat Dec 16 10:37:33 GMT 2023 , Edited by admin on Sat Dec 16 10:37:33 GMT 2023

PRIMARY

FDA UNII

U96GD9R3UZ

Created by admin on Sat Dec 16 10:37:33 GMT 2023 , Edited by admin on Sat Dec 16 10:37:33 GMT 2023

PRIMARY

CAS

1984789-90-3

Created by admin on Sat Dec 16 10:37:33 GMT 2023 , Edited by admin on Sat Dec 16 10:37:33 GMT 2023

PRIMARY

WIKIPEDIA

FUBIMINA

Created by admin on Sat Dec 16 10:37:33 GMT 2023 , Edited by admin on Sat Dec 16 10:37:33 GMT 2023

PRIMARY

FUBIMINA (also known as BIM-2201, BZ-2201 and FTHJ) is a synthetic cannabinoid that is the benzimidazole analog of AM-2201 and has been used as an active ingredient in synthetic cannabis products. It was first identified in Japan in 2013, alongside MEPIRAPIM. FUBIMINA acts as a reasonably potent agonist for the CB2 receptor (Ki = 23.45 nM), with 12x selectivity over CB1 (Ki = 296.1 nM), and does not fully substitute for .DELTA.9-THC in rat discrimination studies. Related benzimidazole derivatives have been reported to be highly selective agonists for the CB2 receptor.

EPA CompTox

DTXSID601016923

Created by admin on Sat Dec 16 10:37:33 GMT 2023 , Edited by admin on Sat Dec 16 10:37:33 GMT 2023

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MANUFACTURER PRODUCT INFORMATION

FUBIMINA

Created by admin on Sat Dec 16 10:37:33 GMT 2023 , Edited by admin on Sat Dec 16 10:37:33 GMT 2023

PRIMARY

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