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Details

Stereochemistry ACHIRAL
Molecular Formula C23H22N2O
Molecular Weight 342.4344
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THJ-018

SMILES

CCCCCn1c2ccccc2c(C(=O)c3cccc4ccccc43)n1

InChI

InChIKey=VAKGBPSFDNTMDJ-UHFFFAOYSA-N
InChI=1S/C23H22N2O/c1-2-3-8-16-25-21-15-7-6-13-20(21)22(24-25)23(26)19-14-9-11-17-10-4-5-12-18(17)19/h4-7,9-15H,2-3,8,16H2,1H3

HIDE SMILES / InChI

Molecular Formula C23H22N2O
Molecular Weight 342.4344
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes.
2016
High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes.
2016 Jan
New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites.
2019
Phase I metabolic profiling of the synthetic cannabinoids THJ-018 and THJ-2201 in human urine in comparison to human liver microsome and cytochrome P450 isoenzyme incubation.
2019 Jul
Substance Class Chemical
Created
by admin
on Sat Jun 26 01:55:47 UTC 2021
Edited
by admin
on Sat Jun 26 01:55:47 UTC 2021
Record UNII
B39WNG6743
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
THJ-018
Common Name English
1-NAPHTHALENYL(1-PENTYL-1H-INDAZOL-3-YL)-METHANONE
Systematic Name English
METHANONE, 1-NAPHTHALENYL(1-PENTYL-1H-INDAZOL-3-YL)-
Systematic Name English
Code System Code Type Description
WIKIPEDIA
THJ-018
Created by admin on Sat Jun 26 01:55:47 UTC 2021 , Edited by admin on Sat Jun 26 01:55:47 UTC 2021
PRIMARY THJ-018 is a synthetic cannabinoid that is the indazole analogue of JWH-018 and has been sold online as a designer drug. THJ-018 is an Anlage II controlled drug in Germany. It is also banned in Sweden.
FDA UNII
B39WNG6743
Created by admin on Sat Jun 26 01:55:47 UTC 2021 , Edited by admin on Sat Jun 26 01:55:47 UTC 2021
PRIMARY
CAS
1364933-55-0
Created by admin on Sat Jun 26 01:55:47 UTC 2021 , Edited by admin on Sat Jun 26 01:55:47 UTC 2021
PRIMARY
MANUFACTURER PRODUCT INFORMATION
THJ-018
Created by admin on Sat Jun 26 01:55:47 UTC 2021 , Edited by admin on Sat Jun 26 01:55:47 UTC 2021
PRIMARY Although this substance has not been formally studied, from analysis of the structure, it is presumed that THJ-018 has a similar binding profile to that of JWH-018 and matches many of the in vivo properties of .DELTA.9-THC. As with JWH-018, THJ-018 exhibits its range of effects via full agonism of both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. THJ-018 is around 5x the potency of .DELTA.9-THC. However, the role of these interactions and how they result in the cannabinoid high experience continues to remain elusive.
PUBCHEM
124518671
Created by admin on Sat Jun 26 01:55:47 UTC 2021 , Edited by admin on Sat Jun 26 01:55:47 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY