U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C6H12O7
Molecular Weight 196.1555
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLUCONIC ACID

SMILES

C([C@]([H])([C@]([H])([C@@]([H])([C@]([H])(C(=O)O)O)O)O)O)O

InChI

InChIKey=RGHNJXZEOKUKBD-SQOUGZDYSA-N
InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1

HIDE SMILES / InChI
Sodium ferric gluconate complex (brand name Ferrlecit by Sanofi) is an intravenously administered iron product. Ferrlecit is an iron complex. It works by providing the body with its necessary level of iron. Ferric gluconate has been shown to be effective in dialysis and non-dialysis associated anemia of chronic kidney disease (CKD). It has also been shown to be effective in improving responses to EPO in chemotherapy induced anemia.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P02792|||Q9BTZ8
Gene ID: 2512.0
Gene Symbol: FTL
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Ferrlecit

Approved Use

Ferrlecit is indicated for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy.

Launch Date

9.1929602E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
12.9 μg/mL
1.5 mg/kg single, intravenous
dose: 1.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLUCONATE ION plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
95 μg × h/mL
1.5 mg/kg single, intravenous
dose: 1.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLUCONATE ION plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2 h
1.5 mg/kg single, intravenous
dose: 1.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLUCONATE ION plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Adverse reactions associated with mobile therapeutic apheresis: analysis of 17,940 procedures.
2001
Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris.
2001
Effects of P5, a novel oxazolo(3,2-a)pyridine derivative with a long-acting antihypertensive activity, on different agonist-mediated pressor responses in pithed rats.
2001 Apr
Properties and modulation of alpha human atrial natriuretic peptide (alpha-hANP)-formed ion channels.
2001 Aug
Electricity and the treatment of hydrofluoric acid burns--the wave of the future or a jolt from the past?
2001 Aug
Iontophoretic delivery of calcium for experimental hydrofluoric acid burns.
2001 Aug
Fatal unintentional occupational poisonings by hydrofluoric acid in the U.S.
2001 Aug
Clinical features, tissue smear and competitive enzyme linked immunosorbent assay as dignostic and prognostic procedures for visceral leishmaniasis in Yemen.
2001 Aug
Crystallization and preliminary X-ray crystallographic studies of recombinant thermoresistant gluconate kinase GntK from Escherichia coli.
2001 Aug
Water-soluble adamantane-terminated dendrimers possessing a rhenium core.
2001 Aug 10
Post-natal ontogeny of stanniocalcin gene expression in rodent kidney and regulation by dietary calcium and phosphate.
2001 Dec
Iron sucrose or ferric gluconate?
2001 Dec
Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds.
2001 Dec 1
Cloning of a Serratia marcescens DNA fragment that induces quinoprotein glucose dehydrogenase-mediated gluconic acid production in Escherichia coli in the presence of stationary phase Serratia marcescens.
2001 Dec 18
Biosynthesis of poly(3-hydroxybutyrate-co-3-mercaptobutyrate) as a sulfur analogue to poly(3-hydroxybutyrate) (PHB).
2001 Fall
Excipient-excipient interaction in the design of sustained-release theophylline tablets: in vitro and in vivo evaluation.
2001 Jul
Cadmium in zinc-containing mineral supplements.
2001 Jul
Effects of naloxone on calcium turnover in cows affected by milk fever.
2001 Jul
Imaging and localization of pancreatic insulinomas.
2001 Jul-Aug
Significance of interferon-gamma in coronary artery bypass surgery.
2001 Jul-Sep
Substrate selectivity of Gluconobacter oxydans for production of 2,5-diketo-D-gluconic acid and synthesis of 2-keto-L-gulonic acid in a multienzyme system.
2001 Jun
Single K+ channels in endocrine cells dispersed from the cricket (Gryllus bimaculatus) corpora allata.
2001 Jun
Hypocalcaemia and hypomagnesaemia due to hydrofluoric acid.
2001 Jun
Calcium L-edge XANES study of some calcium compounds.
2001 Mar 1
Aluminium toxicity and iron homeostasis.
2001 Nov
Functional atrioventricular block in a preterm infant.
2001 Nov
Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes.
2001 Nov 1
An atypical chemical burn.
2001 Nov 3
Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production.
2001 Oct
Hypocalcemia in the newborn.
2001 Oct
Chemical mechanism of beta-xylosidase from Trichoderma reesei QM 9414: pH-dependence of kinetic parameters.
2001 Oct
Considerations for optimal iron use for anemia due to chronic kidney disease.
2001 Oct
99mTc-labeling experiments on CCK(4) by a direct method.
2001 Oct
Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients.
2001 Oct
Lack of allergic reaction to Ferrlecit in a patient with a history of severe pruritic reaction with INFeD.
2001 Oct
Background osmolyte current involved in cell volume regulation of neuroblastoma x glioma hybrid NG108-15 cells.
2001 Sep
On-line coupling of a miniaturized bioreactor with capillary electrophoresis, via a membrane interface, for monitoring the production of organic acids by microorganisms.
2001 Sep
Thioglucosidase activity from Sphingobacterium sp. strain OTG1.
2001 Sep
[Possible treatments of glottic spasm].
2001 Sep
Assessment of selective arterial calcium stimulation and hepatic venous sampling to localize insulin-secreting tumours.
2001 Sep
Intraoperative ultrasound and preoperative localization detects all occult insulinomas; discussion 1025-6.
2001 Sep
Solubility and relative absorption of copper, iron, and zinc in two milk-based liquid infant formulae.
2001 Sep
CFTR modulates programmed cell death by decreasing intracellular pH in Chinese hamster lung fibroblasts.
2001 Sep
Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry.
2001 Sep 14
Anion modulation of the slowly activating vacuolar channel.
2001 Sep 15
Hydrofluoric acid burn from a household rust remover.
2001 Sep 3
Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans.
2001 Sep-Oct
Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties.
2001 Spring
Novel degradable polymers combining D-gluconic acid, a sugar of vegetal origin, with lactic and glycolic acids.
2001 Winter
Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism.
2002 Jan
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
GLUCONIC ACID
HSDB   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
GLUCONIC ACID [VANDF]
Common Name English
GLUCONIC ACID, D-
Common Name English
GLUCONAL GA-50
Common Name English
GLUCONIC ACID [MART.]
Common Name English
NSC-77381
Code English
MALTONIC ACID
Common Name English
GLUCONIC ACID [MI]
Common Name English
DEXTRONIC ACID
Common Name English
E-574
Code English
INS NO.574
Code English
PENTAHYDROXYCAPROIC ACID
Systematic Name English
D-GLUCONIC ACID
Common Name English
GLUCONIC ACID [HSDB]
Common Name English
GLUCONIC ACID [WHO-DD]
Common Name English
GLUCONIC ACID [INCI]
Common Name English
INS-574
Code English
Classification Tree Code System Code
DSLD 1108 (Number of products:5)
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
EPA PESTICIDE CODE 104
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
JECFA EVALUATION INS-574
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
NCI_THESAURUS C360
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
Code System Code Type Description
EVMPD
SUB13980MIG
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
DRUG BANK
DB13180
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
CAS
526-95-4
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
HSDB
487
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
DRUG CENTRAL
3264
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
FDA UNII
R4R8J0Q44B
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
NCI_THESAURUS
C61777
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
MERCK INDEX
M5762
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY Merck Index
EPA CompTox
526-95-4
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
PUBCHEM
10690
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
WIKIPEDIA
GLUCONIC ACID
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
ECHA (EC/EINECS)
208-401-4
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY