Details
Stereochemistry | ABSOLUTE |
Molecular Formula | 2C6H11O7.Mn.2H2O |
Molecular Weight | 481.2633 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 8 / 8 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.[Mn++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O
InChI
InChIKey=FLRDKVYYXANFFA-SYAJEJNSSA-L
InChI=1S/2C6H12O7.Mn.2H2O/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;/h2*2-5,7-11H,1H2,(H,12,13);;2*1H2/q;;+2;;/p-2/t2*2-,3-,4+,5-;;;/m11.../s1
Molecular Formula | C6H12O7 |
Molecular Weight | 196.1553 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | Mn |
Molecular Weight | 54.938 |
Charge | 2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | HO |
Molecular Weight | 17.0073 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Manganese gluconate is a manganese salt of gluconic acid. Manganese gluconate is sometimes used as a food additive for its texture and light pink coloring. As a food additive, manganese gluconate increases satiety, and the texture of processed foods related to mouth feel. However, in recent years, manganese gluconate has been used less and less as a food additive due to its high toxicity. Many food manufacturers have abandoned using manganese gluconate in favor of other chemical compounds that provide similar effects with a lower toxicity. According to the Food and Drug Administration, manganese gluconate is generally recognized as safe, or GRAS. However, high amounts of manganese gluconate intake, upwards of 15 mg per day, may cause potentially serious health risks. Manganese gluconate toxicity may cause a chemical imbalance in the brain, increasing your risk of developing anxiety, depression, nervousness, psychosis, and mania. Manganese gluconate is used for prevention of deficiency and osteoporosis (off-label).
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL4998 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10215764 |
|||
Target ID: CHEMBL1905 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10215764 |
|||
Target ID: CHEMBL3716 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10215764 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Manganese Oligosol Approved UseHypersensitivity |
|||
Preventing | Manganese Approved UsePrevention of manganese deficiency |
PubMed
Title | Date | PubMed |
---|---|---|
In vivo nuclear magnetic resonance imaging of myocardial perfusion using the paramagnetic contrast agent manganese gluconate. | 1989 Aug |
|
In vitro assessment of chemical activation efficiency during in-office dental bleaching. | 2010 May-Jun |
|
Influence of chemical activation of a 35% hydrogen peroxide bleaching gel on its penetration and efficacy--in vitro study. | 2010 Oct |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Can be used parenterally: 150-800 mcg/day IV http://reference.medscape.com/drug/mncl2-manganese-344440
It is not recommended to have more than 20 mg of manganese a day, especially for people with impaired liver function or disease. Anyone considering taking higher doses of manganese (including our 50 mg strength) should do so under a doctor's care. Serving Size: 1 Tablet
Manganese (as manganese gluconate) 5.7 mg
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10215764
1 ug/mL Manganese gluconate induced alpha2 and alpha6 integrins in human basal layer keratinocytes.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:20:20 GMT 2023
by
admin
on
Fri Dec 15 19:20:20 GMT 2023
|
Record UNII |
0O43J7044T
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
SUB79213
Created by
admin on Fri Dec 15 19:20:21 GMT 2023 , Edited by admin on Fri Dec 15 19:20:21 GMT 2023
|
PRIMARY | |||
|
100000138861
Created by
admin on Fri Dec 15 19:20:21 GMT 2023 , Edited by admin on Fri Dec 15 19:20:21 GMT 2023
|
PRIMARY | |||
|
0O43J7044T
Created by
admin on Fri Dec 15 19:20:21 GMT 2023 , Edited by admin on Fri Dec 15 19:20:21 GMT 2023
|
PRIMARY | |||
|
71587398
Created by
admin on Fri Dec 15 19:20:21 GMT 2023 , Edited by admin on Fri Dec 15 19:20:21 GMT 2023
|
PRIMARY | |||
|
104376-80-9
Created by
admin on Fri Dec 15 19:20:21 GMT 2023 , Edited by admin on Fri Dec 15 19:20:21 GMT 2023
|
PRIMARY | |||
|
DTXSID30146440
Created by
admin on Fri Dec 15 19:20:21 GMT 2023 , Edited by admin on Fri Dec 15 19:20:21 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> SALT/SOLVATE | |||
|
PARENT -> SALT/SOLVATE |