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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C6H11O7.Mn.2H2O
Molecular Weight 481.2633
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MANGANESE GLUCONATE DIHYDRATE

SMILES

O.O.[Mn++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=FLRDKVYYXANFFA-SYAJEJNSSA-L
InChI=1S/2C6H12O7.Mn.2H2O/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;/h2*2-5,7-11H,1H2,(H,12,13);;2*1H2/q;;+2;;/p-2/t2*2-,3-,4+,5-;;;/m11.../s1

HIDE SMILES / InChI

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Mn
Molecular Weight 54.938
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H12O7
Molecular Weight 196.1553
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Manganese gluconate is a manganese salt of gluconic acid. Manganese gluconate is sometimes used as a food additive for its texture and light pink coloring. As a food additive, manganese gluconate increases satiety, and the texture of processed foods related to mouth feel. However, in recent years, manganese gluconate has been used less and less as a food additive due to its high toxicity. Many food manufacturers have abandoned using manganese gluconate in favor of other chemical compounds that provide similar effects with a lower toxicity. According to the Food and Drug Administration, manganese gluconate is generally recognized as safe, or GRAS. However, high amounts of manganese gluconate intake, upwards of 15 mg per day, may cause potentially serious health risks. Manganese gluconate toxicity may cause a chemical imbalance in the brain, increasing your risk of developing anxiety, depression, nervousness, psychosis, and mania. Manganese gluconate is used for prevention of deficiency and osteoporosis (off-label).

Approval Year

PubMed

PubMed

TitleDatePubMed
In vivo nuclear magnetic resonance imaging of myocardial perfusion using the paramagnetic contrast agent manganese gluconate.
1989 Aug
Influence of chemical activation of a 35% hydrogen peroxide bleaching gel on its penetration and efficacy--in vitro study.
2010 Oct
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Can be used parenterally: 150-800 mcg/day IV http://reference.medscape.com/drug/mncl2-manganese-344440
It is not recommended to have more than 20 mg of manganese a day, especially for people with impaired liver function or disease. Anyone considering taking higher doses of manganese (including our 50 mg strength) should do so under a doctor's care. Serving Size: 1 Tablet Manganese (as manganese gluconate) 5.7 mg
Route of Administration: Oral
1 ug/mL Manganese gluconate induced alpha2 and alpha6 integrins in human basal layer keratinocytes.
Substance Class Chemical
Created
by admin
on Thu Jul 06 02:27:04 UTC 2023
Edited
by admin
on Thu Jul 06 02:27:04 UTC 2023
Record UNII
0O43J7044T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MANGANESE GLUCONATE DIHYDRATE
Common Name English
MANGANESE, BIS(D-GLUCONATO-O1,O2)-, DIHYDRATE, (T-4)-
Common Name English
MANGANESE GLUCONATE (DIHYDRATE)
Common Name English
MANGANESE, BIS(D-GLUCONATO-.KAPPA.O1,.KAPPA.O2)-, DIHYDRATE, (T-4)-
Common Name English
Code System Code Type Description
EVMPD
SUB79213
Created by admin on Thu Jul 06 02:27:04 UTC 2023 , Edited by admin on Thu Jul 06 02:27:04 UTC 2023
PRIMARY
SMS_ID
100000138861
Created by admin on Thu Jul 06 02:27:04 UTC 2023 , Edited by admin on Thu Jul 06 02:27:04 UTC 2023
PRIMARY
FDA UNII
0O43J7044T
Created by admin on Thu Jul 06 02:27:04 UTC 2023 , Edited by admin on Thu Jul 06 02:27:04 UTC 2023
PRIMARY
PUBCHEM
71587398
Created by admin on Thu Jul 06 02:27:04 UTC 2023 , Edited by admin on Thu Jul 06 02:27:04 UTC 2023
PRIMARY
CAS
104376-80-9
Created by admin on Thu Jul 06 02:27:04 UTC 2023 , Edited by admin on Thu Jul 06 02:27:04 UTC 2023
PRIMARY
EPA CompTox
DTXSID30146440
Created by admin on Thu Jul 06 02:27:04 UTC 2023 , Edited by admin on Thu Jul 06 02:27:04 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE