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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C6H11O7.Mn
Molecular Weight 445.2327
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MANGANESE GLUCONATE ANHYDROUS

SMILES

[Mn++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=OXHQNTSSPHKCPB-IYEMJOQQSA-L
InChI=1S/2C6H12O7.Mn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1

HIDE SMILES / InChI

Molecular Formula Mn
Molecular Weight 54.938
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H11O7
Molecular Weight 195.1473
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Manganese gluconate is a manganese salt of gluconic acid. Manganese gluconate is sometimes used as a food additive for its texture and light pink coloring. As a food additive, manganese gluconate increases satiety, and the texture of processed foods related to mouth feel. However, in recent years, manganese gluconate has been used less and less as a food additive due to its high toxicity. Many food manufacturers have abandoned using manganese gluconate in favor of other chemical compounds that provide similar effects with a lower toxicity. According to the Food and Drug Administration, manganese gluconate is generally recognized as safe, or GRAS. However, high amounts of manganese gluconate intake, upwards of 15 mg per day, may cause potentially serious health risks. Manganese gluconate toxicity may cause a chemical imbalance in the brain, increasing your risk of developing anxiety, depression, nervousness, psychosis, and mania. Manganese gluconate is used for prevention of deficiency and osteoporosis (off-label).

Approval Year

PubMed

PubMed

TitleDatePubMed
In vitro assessment of chemical activation efficiency during in-office dental bleaching.
2010 May-Jun
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Can be used parenterally: 150-800 mcg/day IV http://reference.medscape.com/drug/mncl2-manganese-344440
It is not recommended to have more than 20 mg of manganese a day, especially for people with impaired liver function or disease. Anyone considering taking higher doses of manganese (including our 50 mg strength) should do so under a doctor's care. Serving Size: 1 Tablet Manganese (as manganese gluconate) 5.7 mg
Route of Administration: Oral
1 ug/mL Manganese gluconate induced alpha2 and alpha6 integrins in human basal layer keratinocytes.
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:51:23 UTC 2023
Edited
by admin
on Wed Jul 05 22:51:23 UTC 2023
Record UNII
7G09WJ8QIR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MANGANESE GLUCONATE ANHYDROUS
Common Name English
NSC-132049
Code English
GLUCONIC ACID, MANGANESE SALT (2:1)
Common Name English
MANGANESE, BIS(D-GLUCONATO-O1,O2)-, (T-4)-
Common Name English
MANGANESE, BIS(D-GLUCONATO-.KAPPA.O1,.KAPPA.O2)-, (T-4)-
Common Name English
MANGANESE D-GLUCONATE (1:2)
Common Name English
MANGANESE GLUCONATE [HSDB]
Common Name English
MANGANESE GLUCONATE (ANHYDROUS)
Common Name English
D-GLUCONIC ACID, MANGANESE SALT (2:1)
Common Name English
MANGANESE (II) D-GLUCONATE
Common Name English
Code System Code Type Description
HSDB
1225
Created by admin on Wed Jul 05 22:51:23 UTC 2023 , Edited by admin on Wed Jul 05 22:51:23 UTC 2023
PRIMARY
CAS
6485-39-8
Created by admin on Wed Jul 05 22:51:23 UTC 2023 , Edited by admin on Wed Jul 05 22:51:23 UTC 2023
PRIMARY
ECHA (EC/EINECS)
229-350-4
Created by admin on Wed Jul 05 22:51:23 UTC 2023 , Edited by admin on Wed Jul 05 22:51:23 UTC 2023
PRIMARY
NSC
132049
Created by admin on Wed Jul 05 22:51:23 UTC 2023 , Edited by admin on Wed Jul 05 22:51:23 UTC 2023
PRIMARY
FDA UNII
7G09WJ8QIR
Created by admin on Wed Jul 05 22:51:23 UTC 2023 , Edited by admin on Wed Jul 05 22:51:23 UTC 2023
PRIMARY
PUBCHEM
22988
Created by admin on Wed Jul 05 22:51:23 UTC 2023 , Edited by admin on Wed Jul 05 22:51:23 UTC 2023
PRIMARY
EVMPD
SUB77592
Created by admin on Wed Jul 05 22:51:23 UTC 2023 , Edited by admin on Wed Jul 05 22:51:23 UTC 2023
PRIMARY
EPA CompTox
DTXSID30983438
Created by admin on Wed Jul 05 22:51:23 UTC 2023 , Edited by admin on Wed Jul 05 22:51:23 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE