U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula 2C6H11O7.Co
Molecular Weight 449.2279
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBALTOUS GLUCONATE

SMILES

[Co++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=BMJZVKPTRWYLKB-IYEMJOQQSA-L
InChI=1S/2C6H12O7.Co/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1

HIDE SMILES / InChI
Molecular Formula C6H11O7
Molecular Weight 195.1473
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula Co
Molecular Weight 58.9332
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Brandt, G.
20
Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Hypoxia-inducible factor 1-alpha inhibitor
22
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 1.0 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Improved methods for cobalt filling and silver intensification of insect motor neurons.
1982 Jul
Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH(2)). X-Ray Crystal Structures of [Co(bdoa)(H(2)O)(3)] 3.5H(2)O and {[CO(phen)(3)](bdoa)}(2)24H(2)O (phen = 1,10-Phenanthroline).
1999
Patents

Patents

US20150010463
20
US3459677 A
20
US4326084
20
US5718844
20
US6740618 B2
20
WO2014127808A1
20

Sample Use Guides

In Vivo Use Guide
For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.
Route of Administration: Oral
In Vitro Use Guide
HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:37:18 UTC 2023
Edited
by admin
on Fri Dec 15 15:37:18 UTC 2023
Record UNII
26SK597UWV
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
COBALTOUS GLUCONATE
Common Name English
COBALT(2+) GLUCONATE
Common Name English
Cobalt gluconate [WHO-DD]
Common Name English
COBALT, BIS(D-GLUCONATO-O1,O2)-, (T-4)-
Common Name English
COBALT, BIS(D-GLUCONATO-.KAPPA.O1,.KAPPA.O2)-, (T-4)-
Common Name English
COBALT GLUCONATE [INCI]
Common Name English
COBALTUM GLUCONICUM
Common Name English
BIS(D-GLUCONATO-O1,O2)COBALT
Common Name English
COBALT GLUCONATE
INCI   WHO-DD  
INCI  
Official Name English
Classification Tree Code System Code
DSLD 42 (Number of products:65)
Created by admin on Fri Dec 15 15:37:18 UTC 2023 , Edited by admin on Fri Dec 15 15:37:18 UTC 2023
Code System Code Type Description
DAILYMED
26SK597UWV
Created by admin on Fri Dec 15 15:37:18 UTC 2023 , Edited by admin on Fri Dec 15 15:37:18 UTC 2023
PRIMARY
EPA CompTox
DTXSID60222241
Created by admin on Fri Dec 15 15:37:18 UTC 2023 , Edited by admin on Fri Dec 15 15:37:18 UTC 2023
PRIMARY
CAS
71957-08-9
Created by admin on Fri Dec 15 15:37:18 UTC 2023 , Edited by admin on Fri Dec 15 15:37:18 UTC 2023
PRIMARY
ECHA (EC/EINECS)
276-206-1
Created by admin on Fri Dec 15 15:37:18 UTC 2023 , Edited by admin on Fri Dec 15 15:37:18 UTC 2023
PRIMARY
EVMPD
SUB13409MIG
Created by admin on Fri Dec 15 15:37:18 UTC 2023 , Edited by admin on Fri Dec 15 15:37:18 UTC 2023
PRIMARY
FDA UNII
26SK597UWV
Created by admin on Fri Dec 15 15:37:18 UTC 2023 , Edited by admin on Fri Dec 15 15:37:18 UTC 2023
PRIMARY
PUBCHEM
6451600
Created by admin on Fri Dec 15 15:37:18 UTC 2023 , Edited by admin on Fri Dec 15 15:37:18 UTC 2023
PRIMARY
RXCUI
235987
Created by admin on Fri Dec 15 15:37:18 UTC 2023 , Edited by admin on Fri Dec 15 15:37:18 UTC 2023
PRIMARY RxNorm
SMS_ID
100000076293
Created by admin on Fri Dec 15 15:37:18 UTC 2023 , Edited by admin on Fri Dec 15 15:37:18 UTC 2023
PRIMARY
Related Record Type Details
Structure of GLUCONIC ACID
PARENT -> SALT/SOLVATE
Structure of COBALTOUS CATION
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of COBALTOUS CATION
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966