GLUCONIC ACID

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H12O7
Molecular Weight	196.1553
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O

InChI

InChIKey=RGHNJXZEOKUKBD-SQOUGZDYSA-N

InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C6H12O7
Molecular Weight	196.1553
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://hrcak.srce.hr/file/161891https://www.drugs.com/cdi/ferrlecit.html | https://www.ncbi.nlm.nih.gov/pubmed/28371203

Sodium ferric gluconate complex (brand name Ferrlecit by Sanofi) is an intravenously administered iron product. Ferrlecit is an iron complex. It works by providing the body with its necessary level of iron. Ferric gluconate has been shown to be effective in dialysis and non-dialysis associated anemia of chronic kidney disease (CKD). It has also been shown to be effective in improving responses to EPO in chemotherapy induced anemia.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Ferritin light chain 6 Target ID: P02792\|\|\|Q9BTZ8 Gene ID: 2512.0 Gene Symbol: FTL Target Organism: Homo sapiens (Human) Sources: https://www.drugbank.ca/drugs/DB09517	Binding Agent 1064

Conditions

Condition	Modality	Targets	Highest Phase	Product
Iron deficiency anemia 56 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28391437 https://www.ncbi.nlm.nih.gov/pubmed/26385819 https://www.ncbi.nlm.nih.gov/pubmed/21304025	Primary		Approved 8429	Ferrlecit Approved Use Ferrlecit is indicated for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Launch Date 9.1929602E11
Unknown 2578

C_max

Value	Dose	Co-administered	Analyte	Population
12.9 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
95 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
2 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-034998	http://www.3bsc.com/index/pro_info.php?id=56931
AA Blocks	AA00I9C2	https://www.aablocks.com/goods/Goods/detail?id=AA00I9C2
AHH Chemical co.,ltd	MT-52123	http://www.ahhchemical.com/product/MT-52123.html
AK Scientific, Inc. (AKSCI)	V2121	http://www.aksci.com/item_detail.php?cat=V2121
Aaron Chemicals	AR00IA3U	http://www.aaronchem.com/526-95-4
Acadechem	ACDS-070451	http://www.acadechemical.com/product/145150
Achemtek	0104-021202	http://www.achemtek.com/526-95-4
Acros Organics	AC119890100	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics-2/AC119890100
Acros Organics	AC119890010	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics/AC119890010
Acros Organics	AC119890025	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics/AC119890025
Alfa Aesar	A16806	https://www.alfa.com/en/catalog/A16806/
Alfa Chemistry	157663-13-3	https://www.alfa-chemistry.com/cas_157663-13-3.htm
Angene	AGN-PC-0WADE6	http://www.angenechemical.com/productshow/AGN-PC-0WADE6.html
Aurora Fine Chemicals LLC	A13.111.613	http://online.aurorafinechemicals.com/info?ID=A13.111.613
Avantor Inc	200012-582	https://us.vwr.com/store/product/7516629/sodium-d-gluconate
Avantor Inc	700006-244	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
Avantor Inc	700006-248	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
Avantor Inc	700006-250	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
BLD Pharm	BD305849	http://www.bldpharm.com/products/526-95-4.html
BioSynth	W-109086	https://www.biosynth.com/en/products/life-science/other-biochemicals/products/W-109086.html
Chem Scene	CS-0015343	http://www.chemscene.com/526-95-4.html
Chemspace	CSSB00016994743	https://chem-space.com/CSSB00016994743
Hairui	HR101553	http://www.hairuichem.com/en/product/526-95-4.html
Lab Network	LN00195400	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00195400
Matrix Scientific	99017	https://www.matrixscientific.com/099017.html
MedChem Express	HY-Y0569	https://www.medchemexpress.com/D-Gluconic_acid.html
MuseChem	M102068	https://www.musechem.com/product/M102068.html
MuseChem	R030627	https://www.musechem.com/product/R030627.html
Oakwood	240908	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=121907&ExtHyperLink=1
Oakwood	98946	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=161824&ExtHyperLink=1
Selleck Chemicals	S3595	http://www.selleckchem.com/products/d-gluconic-acid.html
Sigma-Aldrich	G1951_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/g1951?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	12-0635_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/120635?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S054794	http://www.sinfoobiotech.com/product/1058192
Smolecule	S576289	https://www.smolecule.com/products/s576289
TCI (Tokyo Chemical Industry)	G0036	http://www.tcichemicals.com/eshop/en/us/commodity/G0036/index.html
TCI (Tokyo Chemical Industry)	G0038	http://www.tcichemicals.com/eshop/en/us/commodity/G0038/index.html
THE BioTek	bt-432274	https://www.thebiotek.com/product/others/bt-432274
VladaChem	VL279528-25G	https://www.vladachem.com/product.php?products=526-95-4
abcr GmbH	AB116914	http://www.abcr.com/shop/en/AB116914
iChemical	EBD72662	http://www.ichemical.com/products/526-95-4.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs

PubMed

Title	Date	PubMed
Clinical features, tissue smear and competitive enzyme linked immunosorbent assay as dignostic and prognostic procedures for visceral leishmaniasis in Yemen.	2001 Aug	11478434
Post-natal ontogeny of stanniocalcin gene expression in rodent kidney and regulation by dietary calcium and phosphate.	2001 Dec	11737588
Iron sucrose or ferric gluconate?	2001 Dec	11728988
Cryptdin-3 induces novel apical conductance(s) in Cl- secretory, including cystic fibrosis, epithelia.	2001 Feb	11208524
Amount of elemental calcium in calcium solutions.	2001 Feb	11167506
GpdA-promoter-controlled production of glucose oxidase by recombinant Aspergillus niger using nonglucose carbon sources.	2001 Jan	11257807
Inhibitors of the Cl-/HCO3- exchanger activate an anion channel with similar features in the epithelial cells of rabbit gallbladder: patch-clamp analysis.	2001 Jan	11212209
Azospirillum doebereinerae sp. nov., a nitrogen-fixing bacterium associated with the C4-grass Miscanthus.	2001 Jan	11211255
Method development and validation for the determination of various sulfur-containing anions and other anions in the corrosion process by capillary ion electrophoresis with indirect detection.	2001 Jan	11206909
Usefulness of the combination of pre- and intraoperative selective intraarterial calcium injection to detect residual insulinomas.	2001 Jan	11201370
Identification of a new class of biopolymer: bacterial synthesis of a sulfur-containing polymer with thioester linkages.	2001 Jan	11160796
Effects of naloxone on calcium turnover in cows affected by milk fever.	2001 Jul	11467812
Apical membrane of native OMCD(i) cells has nonselective cation channels.	2001 Jul	11399645
Primary hypoparathyroidism in a cat complicated by suspect iatrogenic calcinosis cutis.	2001 Jul-Aug	11450838
Sugar-free zinc gluconate glycine lozenges (Cold-Eeze) do not adversely affect glucose control in patients with type 1 or type 2 diabetes mellitus.	2001 Jul-Aug	11441324
Hypocalcaemia and hypomagnesaemia due to hydrofluoric acid.	2001 Jun	11463875
Heterologous expression of the acyl-acyl carrier protein thioesterase gene from the plant Umbellularia californica mediates polyhydroxyalkanoate biosynthesis in recombinant Escherichia coli.	2001 Mar	11330715
Calcium L-edge XANES study of some calcium compounds.	2001 Mar 1	11512744
Variation of enzyme activities at a branched pathway involved in the utilization of gluconate in Escherichia coli.	2001 May	11430650
Bursting activity in leech Retzius neurons induced by low external chloride.	2001 May	11417224
Lymph osmolality and rehydration from NaCl solutions by toads, Bufo marinus.	2001 May	11409625
Calcinosis cutis as a complication of parenteral calcium gluconate therapy.	2001 May	11343063
Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes.	2001 Nov 1	11597353
An atypical chemical burn.	2001 Nov 3	11705565
99mTc-labeling experiments on CCK(4) by a direct method.	2001 Oct	11578909
Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients.	2001 Oct	11576360
[Possible treatments of glottic spasm].	2001 Sep	11593774
Novel degradable polymers combining D-gluconic acid, a sugar of vegetal origin, with lactic and glycolic acids.	2001 Winter	11777404

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:19:17 UTC 2023` Edited by `admin` on `Fri Dec 15 15:19:17 UTC 2023`
Record UNII	R4R8J0Q44B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLUCONIC ACID

Official Name

English

GLUCONIC ACID [VANDF]

Common Name

English

GLUCONIC ACID, D-

Common Name

English

GLUCONAL GA-50

Common Name

English

GLUCONIC ACID [MART.]

Common Name

English

NSC-77381

Code

English

MALTONIC ACID

Common Name

English

GLUCONIC ACID [MI]

Common Name

English

DEXTRONIC ACID

Common Name

English

E-574

Code

English

INS NO.574

Code

English

PENTAHYDROXYCAPROIC ACID

Systematic Name

English

D-GLUCONIC ACID

Common Name

English

Gluconic acid [WHO-DD]

Common Name

English

GLUCONIC ACID [HSDB]

Common Name

English

GLUCONIC ACID [INCI]

Common Name

English

INS-574

Code

English

Classification Tree Code System Code

DSLD

1108 (Number of products:5)