U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C6H12O7
Molecular Weight 196.1553
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLUCONIC ACID

SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O

InChI

InChIKey=RGHNJXZEOKUKBD-SQOUGZDYSA-N
InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1

HIDE SMILES / InChI

Molecular Formula C6H12O7
Molecular Weight 196.1553
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Sodium ferric gluconate complex (brand name Ferrlecit by Sanofi) is an intravenously administered iron product. Ferrlecit is an iron complex. It works by providing the body with its necessary level of iron. Ferric gluconate has been shown to be effective in dialysis and non-dialysis associated anemia of chronic kidney disease (CKD). It has also been shown to be effective in improving responses to EPO in chemotherapy induced anemia.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P02792|||Q9BTZ8
Gene ID: 2512.0
Gene Symbol: FTL
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Ferrlecit

Approved Use

Ferrlecit is indicated for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy.

Launch Date

1999
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
12.9 μg/mL
1.5 mg/kg single, intravenous
dose: 1.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLUCONATE ION plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
95 μg × h/mL
1.5 mg/kg single, intravenous
dose: 1.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLUCONATE ION plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2 h
1.5 mg/kg single, intravenous
dose: 1.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLUCONATE ION plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Adverse reactions associated with mobile therapeutic apheresis: analysis of 17,940 procedures.
2001
Involvement of gntS in the control of GntI, the main system for gluconate metabolism in Escherichia coli.
2001
Properties and modulation of alpha human atrial natriuretic peptide (alpha-hANP)-formed ion channels.
2001 Aug
Electricity and the treatment of hydrofluoric acid burns--the wave of the future or a jolt from the past?
2001 Aug
Iontophoretic delivery of calcium for experimental hydrofluoric acid burns.
2001 Aug
Fatal unintentional occupational poisonings by hydrofluoric acid in the U.S.
2001 Aug
Crystallization and preliminary X-ray crystallographic studies of recombinant thermoresistant gluconate kinase GntK from Escherichia coli.
2001 Aug
Functional and molecular characterization of the K-Cl cotransporter of Xenopus laevis oocytes.
2001 Aug
Water-soluble adamantane-terminated dendrimers possessing a rhenium core.
2001 Aug 10
Post-natal ontogeny of stanniocalcin gene expression in rodent kidney and regulation by dietary calcium and phosphate.
2001 Dec
Cloning of a Serratia marcescens DNA fragment that induces quinoprotein glucose dehydrogenase-mediated gluconic acid production in Escherichia coli in the presence of stationary phase Serratia marcescens.
2001 Dec 18
Excipient-excipient interaction in the design of sustained-release theophylline tablets: in vitro and in vivo evaluation.
2001 Jul
Effects of naloxone on calcium turnover in cows affected by milk fever.
2001 Jul
A successful monitoring for intraoperative calcium stimulation test in complete resection of pancreatic insulinoma.
2001 Jul
The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erythropoietin.
2001 Jul
Simplified citrate anticoagulation for continuous renal replacement therapy.
2001 Jul
Imaging and localization of pancreatic insulinomas.
2001 Jul-Aug
Primary hypoparathyroidism in a cat complicated by suspect iatrogenic calcinosis cutis.
2001 Jul-Aug
Severe calcinosis cutis associated with treatment of hypoparathyroidism in a dog.
2001 Jul-Aug
Organ heavy-metal accumulation during parenteral nutrition is associated with pathologic abnormalities in rats.
2001 Jul-Aug
Simple glucal-based linker for the immobilization of alcohols on solid support.
2001 Jul-Aug
Sugar-free zinc gluconate glycine lozenges (Cold-Eeze) do not adversely affect glucose control in patients with type 1 or type 2 diabetes mellitus.
2001 Jul-Aug
Significance of interferon-gamma in coronary artery bypass surgery.
2001 Jul-Sep
Substrate selectivity of Gluconobacter oxydans for production of 2,5-diketo-D-gluconic acid and synthesis of 2-keto-L-gulonic acid in a multienzyme system.
2001 Jun
Single K+ channels in endocrine cells dispersed from the cricket (Gryllus bimaculatus) corpora allata.
2001 Jun
Hypocalcaemia and hypomagnesaemia due to hydrofluoric acid.
2001 Jun
Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus.
2001 Jun
Comparison of two platelet additive solutions.
2001 Jun
A deeper investigation on carbohydrate cycling in Sinorhizobium meliloti.
2001 Jun 15
Calcium L-edge XANES study of some calcium compounds.
2001 Mar 1
Variation of enzyme activities at a branched pathway involved in the utilization of gluconate in Escherichia coli.
2001 May
Bursting activity in leech Retzius neurons induced by low external chloride.
2001 May
Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes.
2001 Nov 1
An atypical chemical burn.
2001 Nov 3
Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production.
2001 Oct
Hypocalcemia in the newborn.
2001 Oct
Considerations for optimal iron use for anemia due to chronic kidney disease.
2001 Oct
99mTc-labeling experiments on CCK(4) by a direct method.
2001 Oct
Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients.
2001 Oct
Lack of allergic reaction to Ferrlecit in a patient with a history of severe pruritic reaction with INFeD.
2001 Oct
Background osmolyte current involved in cell volume regulation of neuroblastoma x glioma hybrid NG108-15 cells.
2001 Sep
[Possible treatments of glottic spasm].
2001 Sep
Assessment of selective arterial calcium stimulation and hepatic venous sampling to localize insulin-secreting tumours.
2001 Sep
Intraoperative ultrasound and preoperative localization detects all occult insulinomas; discussion 1025-6.
2001 Sep
Solubility and relative absorption of copper, iron, and zinc in two milk-based liquid infant formulae.
2001 Sep
CFTR modulates programmed cell death by decreasing intracellular pH in Chinese hamster lung fibroblasts.
2001 Sep
Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry.
2001 Sep 14
Hydrofluoric acid burn from a household rust remover.
2001 Sep 3
Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties.
2001 Spring
Novel degradable polymers combining D-gluconic acid, a sugar of vegetal origin, with lactic and glycolic acids.
2001 Winter
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:19:17 GMT 2023
Edited
by admin
on Fri Dec 15 15:19:17 GMT 2023
Record UNII
R4R8J0Q44B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLUCONIC ACID
HSDB   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
GLUCONIC ACID [VANDF]
Common Name English
GLUCONIC ACID, D-
Common Name English
GLUCONAL GA-50
Common Name English
GLUCONIC ACID [MART.]
Common Name English
NSC-77381
Code English
MALTONIC ACID
Common Name English
GLUCONIC ACID [MI]
Common Name English
DEXTRONIC ACID
Common Name English
E-574
Code English
INS NO.574
Code English
PENTAHYDROXYCAPROIC ACID
Systematic Name English
D-GLUCONIC ACID
Common Name English
Gluconic acid [WHO-DD]
Common Name English
GLUCONIC ACID [HSDB]
Common Name English
GLUCONIC ACID [INCI]
Common Name English
INS-574
Code English
Classification Tree Code System Code
DSLD 1108 (Number of products:5)
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
EPA PESTICIDE CODE 104
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
JECFA EVALUATION INS-574
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
NCI_THESAURUS C360
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
Code System Code Type Description
CHEBI
33198
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
EVMPD
SUB13980MIG
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
DRUG BANK
DB13180
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
CAS
526-95-4
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
HSDB
487
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
DRUG CENTRAL
3264
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
FDA UNII
R4R8J0Q44B
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
RXCUI
2475956
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
NCI_THESAURUS
C61777
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
MERCK INDEX
m5762
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY Merck Index
DAILYMED
R4R8J0Q44B
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
SMS_ID
100000078190
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
NSC
77381
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
EPA CompTox
DTXSID8027169
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
PUBCHEM
10690
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
WIKIPEDIA
GLUCONIC ACID
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
ECHA (EC/EINECS)
208-401-4
Created by admin on Fri Dec 15 15:19:18 GMT 2023 , Edited by admin on Fri Dec 15 15:19:18 GMT 2023
PRIMARY
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