U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C6H12O7
Molecular Weight 196.1555
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLUCONIC ACID

SMILES

C([C@]([H])([C@]([H])([C@@]([H])([C@]([H])(C(=O)O)O)O)O)O)O

InChI

InChIKey=RGHNJXZEOKUKBD-SQOUGZDYSA-N
InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1

HIDE SMILES / InChI

Molecular Formula C6H12O7
Molecular Weight 196.1555
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Sodium ferric gluconate complex (brand name Ferrlecit by Sanofi) is an intravenously administered iron product. Ferrlecit is an iron complex. It works by providing the body with its necessary level of iron. Ferric gluconate has been shown to be effective in dialysis and non-dialysis associated anemia of chronic kidney disease (CKD). It has also been shown to be effective in improving responses to EPO in chemotherapy induced anemia.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P02792|||Q9BTZ8
Gene ID: 2512.0
Gene Symbol: FTL
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Ferrlecit

Approved Use

Ferrlecit is indicated for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy.

Launch Date

9.1929602E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
12.9 μg/mL
1.5 mg/kg single, intravenous
dose: 1.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLUCONATE ION plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
95 μg × h/mL
1.5 mg/kg single, intravenous
dose: 1.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLUCONATE ION plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2 h
1.5 mg/kg single, intravenous
dose: 1.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLUCONATE ION plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris.
2001
Involvement of gntS in the control of GntI, the main system for gluconate metabolism in Escherichia coli.
2001
Properties and modulation of alpha human atrial natriuretic peptide (alpha-hANP)-formed ion channels.
2001 Aug
Iontophoretic delivery of calcium for experimental hydrofluoric acid burns.
2001 Aug
Crystallization and preliminary X-ray crystallographic studies of recombinant thermoresistant gluconate kinase GntK from Escherichia coli.
2001 Aug
Functional and molecular characterization of the K-Cl cotransporter of Xenopus laevis oocytes.
2001 Aug
Cloning of a Serratia marcescens DNA fragment that induces quinoprotein glucose dehydrogenase-mediated gluconic acid production in Escherichia coli in the presence of stationary phase Serratia marcescens.
2001 Dec 18
Cryptdin-3 induces novel apical conductance(s) in Cl- secretory, including cystic fibrosis, epithelia.
2001 Feb
Chloride conductance and volume-regulatory nonselective cation conductance in human red blood cell ghosts.
2001 Jan
Inhibitors of the Cl-/HCO3- exchanger activate an anion channel with similar features in the epithelial cells of rabbit gallbladder: patch-clamp analysis.
2001 Jan
Azospirillum doebereinerae sp. nov., a nitrogen-fixing bacterium associated with the C4-grass Miscanthus.
2001 Jan
Method development and validation for the determination of various sulfur-containing anions and other anions in the corrosion process by capillary ion electrophoresis with indirect detection.
2001 Jan
Usefulness of the combination of pre- and intraoperative selective intraarterial calcium injection to detect residual insulinomas.
2001 Jan
Excipient-excipient interaction in the design of sustained-release theophylline tablets: in vitro and in vivo evaluation.
2001 Jul
A successful monitoring for intraoperative calcium stimulation test in complete resection of pancreatic insulinoma.
2001 Jul
The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erythropoietin.
2001 Jul
Simplified citrate anticoagulation for continuous renal replacement therapy.
2001 Jul
Imaging and localization of pancreatic insulinomas.
2001 Jul-Aug
Primary hypoparathyroidism in a cat complicated by suspect iatrogenic calcinosis cutis.
2001 Jul-Aug
Organ heavy-metal accumulation during parenteral nutrition is associated with pathologic abnormalities in rats.
2001 Jul-Aug
Simple glucal-based linker for the immobilization of alcohols on solid support.
2001 Jul-Aug
Sugar-free zinc gluconate glycine lozenges (Cold-Eeze) do not adversely affect glucose control in patients with type 1 or type 2 diabetes mellitus.
2001 Jul-Aug
Significance of interferon-gamma in coronary artery bypass surgery.
2001 Jul-Sep
Hypocalcaemia and hypomagnesaemia due to hydrofluoric acid.
2001 Jun
Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus.
2001 Jun
Comparison of two platelet additive solutions.
2001 Jun
A deeper investigation on carbohydrate cycling in Sinorhizobium meliloti.
2001 Jun 15
Capillary electrophoresis for measuring major and trace anions in thermal water and condensed-steam samples from hydrothermal springs and fumaroles.
2001 Jun 22
Heterologous expression of the acyl-acyl carrier protein thioesterase gene from the plant Umbellularia californica mediates polyhydroxyalkanoate biosynthesis in recombinant Escherichia coli.
2001 Mar
Variation of enzyme activities at a branched pathway involved in the utilization of gluconate in Escherichia coli.
2001 May
Bursting activity in leech Retzius neurons induced by low external chloride.
2001 May
HCO3- potentiates the cAMP-dependent secretory response of the human distal colon through a DIDS-sensitive pathway.
2001 May
Lymph osmolality and rehydration from NaCl solutions by toads, Bufo marinus.
2001 May
Periplasmic PQQ-dependent glucose oxidation in free-living and symbiotic rhizobia.
2001 May
Management of extravasation injuries.
2001 May
Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production.
2001 Oct
Hypocalcemia in the newborn.
2001 Oct
99mTc-labeling experiments on CCK(4) by a direct method.
2001 Oct
Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients.
2001 Oct
Lack of allergic reaction to Ferrlecit in a patient with a history of severe pruritic reaction with INFeD.
2001 Oct
Background osmolyte current involved in cell volume regulation of neuroblastoma x glioma hybrid NG108-15 cells.
2001 Sep
Intraoperative ultrasound and preoperative localization detects all occult insulinomas; discussion 1025-6.
2001 Sep
Solubility and relative absorption of copper, iron, and zinc in two milk-based liquid infant formulae.
2001 Sep
Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry.
2001 Sep 14
Anion modulation of the slowly activating vacuolar channel.
2001 Sep 15
Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans.
2001 Sep-Oct
Novel degradable polymers combining D-gluconic acid, a sugar of vegetal origin, with lactic and glycolic acids.
2001 Winter
In vitro study on the effects of iron sucrose, ferric gluconate and iron dextran on redox-active iron and oxidative stress.
2010
The available intravenous iron formulations: History, efficacy, and toxicology.
2017 Jun
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:15:08 UTC 2021
Edited
by admin
on Sat Jun 26 04:15:08 UTC 2021
Record UNII
R4R8J0Q44B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLUCONIC ACID
HSDB   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
GLUCONIC ACID [VANDF]
Common Name English
GLUCONIC ACID, D-
Common Name English
GLUCONAL GA-50
Common Name English
GLUCONIC ACID [MART.]
Common Name English
NSC-77381
Code English
MALTONIC ACID
Common Name English
GLUCONIC ACID [MI]
Common Name English
DEXTRONIC ACID
Common Name English
E-574
Code English
INS NO.574
Code English
PENTAHYDROXYCAPROIC ACID
Systematic Name English
D-GLUCONIC ACID
Common Name English
GLUCONIC ACID [HSDB]
Common Name English
GLUCONIC ACID [WHO-DD]
Common Name English
GLUCONIC ACID [INCI]
Common Name English
INS-574
Code English
Classification Tree Code System Code
DSLD 1108 (Number of products:5)
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
EPA PESTICIDE CODE 104
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
JECFA EVALUATION INS-574
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
NCI_THESAURUS C360
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
Code System Code Type Description
EVMPD
SUB13980MIG
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
DRUG BANK
DB13180
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
CAS
526-95-4
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
HSDB
487
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
DRUG CENTRAL
3264
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
FDA UNII
R4R8J0Q44B
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
NCI_THESAURUS
C61777
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
MERCK INDEX
M5762
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY Merck Index
EPA CompTox
526-95-4
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
PUBCHEM
10690
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
WIKIPEDIA
GLUCONIC ACID
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
ECHA (EC/EINECS)
208-401-4
Created by admin on Sat Jun 26 04:15:10 UTC 2021 , Edited by admin on Sat Jun 26 04:15:10 UTC 2021
PRIMARY
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