GLUCONIC ACID

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H12O7
Molecular Weight	196.1553
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O

InChI

InChIKey=RGHNJXZEOKUKBD-SQOUGZDYSA-N

InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C6H12O7
Molecular Weight	196.1553
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.drugs.com/cdi/ferrlecit.html | https://www.ncbi.nlm.nih.gov/pubmed/28371203http://hrcak.srce.hr/file/161891

Gluconic acid is a natural compound produced from glucose through a simple dehydrogenation reaction catalysed by glucose oxidase. Gluconic acid and its salts are used in the formulation of food, pharmaceutical and hygienic products.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Ferritin light chain 6 Target ID: P02792\|\|\|Q9BTZ8 Gene ID: 2512.0 Gene Symbol: FTL Target Organism: Homo sapiens (Human) Sources: https://www.drugbank.ca/drugs/DB09517	Binding Agent 1059

Conditions

Condition	Modality	Targets	Highest Phase	Product
Iron deficiency anemia 55 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28391437 https://www.ncbi.nlm.nih.gov/pubmed/26385819 https://www.ncbi.nlm.nih.gov/pubmed/21304025	Primary		Approved 8360	Ferrlecit Approved Use Ferrlecit is indicated for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Launch Date 9.1929602E11
Unknown 2565

C_max

Value	Dose	Co-administered	Analyte	Population
12.9 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
95 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
2 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-034998	http://www.3bsc.com/index/pro_info.php?id=56931
AA Blocks	AA00I9C2	https://www.aablocks.com/goods/Goods/detail?id=AA00I9C2
AHH Chemical co.,ltd	MT-52123	http://www.ahhchemical.com/product/MT-52123.html
AK Scientific, Inc. (AKSCI)	V2121	http://www.aksci.com/item_detail.php?cat=V2121
Aaron Chemicals	AR00IA3U	http://www.aaronchem.com/526-95-4
Acadechem	ACDS-070451	http://www.acadechemical.com/product/145150
Achemtek	0104-021202	http://www.achemtek.com/526-95-4
Acros Organics	AC119890100	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics-2/AC119890100
Acros Organics	AC119890010	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics/AC119890010
Acros Organics	AC119890025	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics/AC119890025
Alfa Aesar	A16806	https://www.alfa.com/en/catalog/A16806/
Alfa Chemistry	157663-13-3	https://www.alfa-chemistry.com/cas_157663-13-3.htm
Angene	AGN-PC-0WADE6	http://www.angenechemical.com/productshow/AGN-PC-0WADE6.html
Aurora Fine Chemicals LLC	A13.111.613	http://online.aurorafinechemicals.com/info?ID=A13.111.613
Avantor Inc	200012-582	https://us.vwr.com/store/product/7516629/sodium-d-gluconate
Avantor Inc	700006-244	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
Avantor Inc	700006-248	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
Avantor Inc	700006-250	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
BLD Pharm	BD305849	http://www.bldpharm.com/products/526-95-4.html
BioSynth	W-109086	https://www.biosynth.com/en/products/life-science/other-biochemicals/products/W-109086.html
Chem Scene	CS-0015343	http://www.chemscene.com/526-95-4.html
Chemspace	CSSB00016994743	https://chem-space.com/CSSB00016994743
Hairui	HR101553	http://www.hairuichem.com/en/product/526-95-4.html
Lab Network	LN00195400	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00195400
Matrix Scientific	99017	https://www.matrixscientific.com/099017.html
MedChem Express	HY-Y0569	https://www.medchemexpress.com/D-Gluconic_acid.html
MuseChem	M102068	https://www.musechem.com/product/M102068.html
MuseChem	R030627	https://www.musechem.com/product/R030627.html
Oakwood	240908	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=121907&ExtHyperLink=1
Oakwood	98946	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=161824&ExtHyperLink=1
Selleck Chemicals	S3595	http://www.selleckchem.com/products/d-gluconic-acid.html
Sigma-Aldrich	G1951_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/g1951?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	12-0635_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/120635?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S054794	http://www.sinfoobiotech.com/product/1058192
Smolecule	S576289	https://www.smolecule.com/products/s576289
TCI (Tokyo Chemical Industry)	G0036	http://www.tcichemicals.com/eshop/en/us/commodity/G0036/index.html
TCI (Tokyo Chemical Industry)	G0038	http://www.tcichemicals.com/eshop/en/us/commodity/G0038/index.html
THE BioTek	bt-432274	https://www.thebiotek.com/product/others/bt-432274
VladaChem	VL279528-25G	https://www.vladachem.com/product.php?products=526-95-4
abcr GmbH	AB116914	http://www.abcr.com/shop/en/AB116914
iChemical	EBD72662	http://www.ichemical.com/products/526-95-4.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs

PubMed

Title	Date	PubMed

Adverse reactions associated with mobile therapeutic apheresis: analysis of 17,940 procedures.	2001	11746539
Effects of P5, a novel oxazolo(3,2-a)pyridine derivative with a long-acting antihypertensive activity, on different agonist-mediated pressor responses in pithed rats.	2001 Apr	11679017
Crystallization and preliminary X-ray crystallographic studies of recombinant thermoresistant gluconate kinase GntK from Escherichia coli.	2001 Aug	11468405
Iron sucrose or ferric gluconate?	2001 Dec	11728988
Post-natal ontogeny of stanniocalcin gene expression in rodent kidney and regulation by dietary calcium and phosphate.	2001 Dec	11737588
Biosynthesis of poly(3-hydroxybutyrate-co-3-mercaptobutyrate) as a sulfur analogue to poly(3-hydroxybutyrate) (PHB).	2001 Fall	11710011
Cryptdin-3 induces novel apical conductance(s) in Cl- secretory, including cystic fibrosis, epithelia.	2001 Feb	11208524
Observations on amphotericin B treatment of kala-azar given in a rural set up in Bihar, India.	2001 Jan	11280166
Inhibitors of the Cl-/HCO3- exchanger activate an anion channel with similar features in the epithelial cells of rabbit gallbladder: patch-clamp analysis.	2001 Jan	11212209
Azospirillum doebereinerae sp. nov., a nitrogen-fixing bacterium associated with the C4-grass Miscanthus.	2001 Jan	11211255
Method development and validation for the determination of various sulfur-containing anions and other anions in the corrosion process by capillary ion electrophoresis with indirect detection.	2001 Jan	11206909
Usefulness of the combination of pre- and intraoperative selective intraarterial calcium injection to detect residual insulinomas.	2001 Jan	11201370
Saphenous vein endothelial cell viability: a comparative study of endoscopic and open saphenectomy for coronary artery bypass grafting.	2001 Jan-Mar	11303993
Simplified citrate anticoagulation for continuous renal replacement therapy.	2001 Jul	11422774
Gluconobacter oxydans: its biotechnological applications.	2001 Jul	11361077
Imaging and localization of pancreatic insulinomas.	2001 Jul-Aug	11566091
Organ heavy-metal accumulation during parenteral nutrition is associated with pathologic abnormalities in rats.	2001 Jul-Aug	11448580
Hypocalcaemia and hypomagnesaemia due to hydrofluoric acid.	2001 Jun	11463875
Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus.	2001 Jun	11444416
A randomized, controlled parallel-group trial on efficacy and safety of iron sucrose (Venofer) vs iron gluconate (Ferrlecit) in haemodialysis patients treated with rHuEpo.	2001 Jun	11390726
Ionochromic properties of long-wave-sensitive cones in the goldfish retina: an electrophysiological and microspectrophotometric study.	2001 Jun	11369039
Heterologous expression of the acyl-acyl carrier protein thioesterase gene from the plant Umbellularia californica mediates polyhydroxyalkanoate biosynthesis in recombinant Escherichia coli.	2001 Mar	11330715
Management of extravasation injuries.	2001 May	11374477
Blocking swelling-activated chloride current inhibits mouse liver cell proliferation.	2001 May 1	11313437
Aluminium toxicity and iron homeostasis.	2001 Nov	11709207
Functional atrioventricular block in a preterm infant.	2001 Nov	11668169
Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes.	2001 Nov 1	11597353
Hypocalcemia in the newborn.	2001 Oct	11758136
Chemical mechanism of beta-xylosidase from Trichoderma reesei QM 9414: pH-dependence of kinetic parameters.	2001 Oct	11728634
Considerations for optimal iron use for anemia due to chronic kidney disease.	2001 Oct	11726002
On-line coupling of a miniaturized bioreactor with capillary electrophoresis, via a membrane interface, for monitoring the production of organic acids by microorganisms.	2001 Sep	11678187
Thioglucosidase activity from Sphingobacterium sp. strain OTG1.	2001 Sep	11601617
[Possible treatments of glottic spasm].	2001 Sep	11593774
Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry.	2001 Sep 14	11587333
Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties.	2001 Spring	11749154
Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism.	2002 Jan	11746779
The available intravenous iron formulations: History, efficacy, and toxicology.	2017 Jun	28371203

Patents

Sample Use Guides

In Vivo Use Guide

8 weeks of IV ferric gluconate 125 mg weekly

Route of Administration: Intravenous

In Vitro Use Guide

The effect of iron(III)-gluconate (Ferlixit) at various concentrations on the malondialdehyde production in isolated rat liver mitochondria was studied. Concentratiors of iron as low as 100 uM are able to elicit a significant enhancement of lipid peroxidation. process.

Substance Class	Chemical Created by `admin` on `Wed Jul 05 22:50:12 UTC 2023` Edited by `admin` on `Wed Jul 05 22:50:12 UTC 2023`
Record UNII	R4R8J0Q44B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLUCONIC ACID

Official Name

English

GLUCONIC ACID [VANDF]

Common Name

English

GLUCONIC ACID, D-

Common Name

English

GLUCONAL GA-50

Common Name

English

GLUCONIC ACID [MART.]

Common Name

English

NSC-77381

Code

English

MALTONIC ACID

Common Name

English

GLUCONIC ACID [MI]

Common Name

English

DEXTRONIC ACID

Common Name

English

E-574

Code

English

INS NO.574

Code

English

PENTAHYDROXYCAPROIC ACID

Systematic Name

English

D-GLUCONIC ACID

Common Name

English

Gluconic acid [WHO-DD]

Common Name

English

GLUCONIC ACID [HSDB]

Common Name

English

GLUCONIC ACID [INCI]

Common Name

English

INS-574

Code

English

Classification Tree Code System Code

DSLD

1108 (Number of products:5)