Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C6H12O7.H3N |
| Molecular Weight | 213.1858 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O
InChI
InChIKey=XLCNHLXQKYRGKZ-JJKGCWMISA-N
InChI=1S/C6H12O7.H3N/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);1H3/t2-,3-,4+,5-;/m1./s1
| Molecular Formula | C6H12O7 |
| Molecular Weight | 196.1553 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | H3N |
| Molecular Weight | 17.0305 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P02792|||Q9BTZ8 Gene ID: 2512.0 Gene Symbol: FTL Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Ferrlecit Approved UseFerrlecit is indicated for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Launch Date1999 |
|||
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
12.9 μg/mL |
1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GLUCONATE ION plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
95 μg × h/mL |
1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GLUCONATE ION plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
2 h |
1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GLUCONATE ION plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
OverviewOther
| Other Inhibitor | Other Substrate | Other Inducer |
|---|---|---|
Drug as perpetrator
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
| inconclusive [IC50 35.5162 uM] | ||||
| inconclusive [IC50 63.1577 uM] | ||||
| no | ||||
| no | ||||
| yes [IC50 89.2126 uM] |
Tox targets
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Adverse reactions associated with mobile therapeutic apheresis: analysis of 17,940 procedures. | 2001 |
|
| Effects of P5, a novel oxazolo(3,2-a)pyridine derivative with a long-acting antihypertensive activity, on different agonist-mediated pressor responses in pithed rats. | 2001 Apr |
|
| Properties and modulation of alpha human atrial natriuretic peptide (alpha-hANP)-formed ion channels. | 2001 Aug |
|
| Crystallization and preliminary X-ray crystallographic studies of recombinant thermoresistant gluconate kinase GntK from Escherichia coli. | 2001 Aug |
|
| Water-soluble adamantane-terminated dendrimers possessing a rhenium core. | 2001 Aug 10 |
|
| Iron sucrose or ferric gluconate? | 2001 Dec |
|
| Post-natal ontogeny of stanniocalcin gene expression in rodent kidney and regulation by dietary calcium and phosphate. | 2001 Dec |
|
| Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds. | 2001 Dec 1 |
|
| Cloning of a Serratia marcescens DNA fragment that induces quinoprotein glucose dehydrogenase-mediated gluconic acid production in Escherichia coli in the presence of stationary phase Serratia marcescens. | 2001 Dec 18 |
|
| Biosynthesis of poly(3-hydroxybutyrate-co-3-mercaptobutyrate) as a sulfur analogue to poly(3-hydroxybutyrate) (PHB). | 2001 Fall |
|
| Saphenous vein endothelial cell viability: a comparative study of endoscopic and open saphenectomy for coronary artery bypass grafting. | 2001 Jan-Mar |
|
| Excipient-excipient interaction in the design of sustained-release theophylline tablets: in vitro and in vivo evaluation. | 2001 Jul |
|
| Cadmium in zinc-containing mineral supplements. | 2001 Jul |
|
| A successful monitoring for intraoperative calcium stimulation test in complete resection of pancreatic insulinoma. | 2001 Jul |
|
| Apical membrane of native OMCD(i) cells has nonselective cation channels. | 2001 Jul |
|
| Gluconobacter oxydans: its biotechnological applications. | 2001 Jul |
|
| Primary hypoparathyroidism in a cat complicated by suspect iatrogenic calcinosis cutis. | 2001 Jul-Aug |
|
| Sugar-free zinc gluconate glycine lozenges (Cold-Eeze) do not adversely affect glucose control in patients with type 1 or type 2 diabetes mellitus. | 2001 Jul-Aug |
|
| Significance of interferon-gamma in coronary artery bypass surgery. | 2001 Jul-Sep |
|
| Comparison of two platelet additive solutions. | 2001 Jun |
|
| A randomized, controlled parallel-group trial on efficacy and safety of iron sucrose (Venofer) vs iron gluconate (Ferrlecit) in haemodialysis patients treated with rHuEpo. | 2001 Jun |
|
| Intravenous calcium gluconate in the treatment of hydrofluoric acid burns. | 2001 Jun |
|
| Ionochromic properties of long-wave-sensitive cones in the goldfish retina: an electrophysiological and microspectrophotometric study. | 2001 Jun |
|
| Heterologous expression of the acyl-acyl carrier protein thioesterase gene from the plant Umbellularia californica mediates polyhydroxyalkanoate biosynthesis in recombinant Escherichia coli. | 2001 Mar |
|
| Calcium L-edge XANES study of some calcium compounds. | 2001 Mar 1 |
|
| Variation of enzyme activities at a branched pathway involved in the utilization of gluconate in Escherichia coli. | 2001 May |
|
| Lymph osmolality and rehydration from NaCl solutions by toads, Bufo marinus. | 2001 May |
|
| Periplasmic PQQ-dependent glucose oxidation in free-living and symbiotic rhizobia. | 2001 May |
|
| Production of glucose-fructose oxidoreductase and ethanol by Zymomonas mobilis ATCC 29191 in medium containing corn steep liquor as a source of vitamins. | 2001 May |
|
| Management of extravasation injuries. | 2001 May |
|
| Aluminium toxicity and iron homeostasis. | 2001 Nov |
|
| Functional atrioventricular block in a preterm infant. | 2001 Nov |
|
| An atypical chemical burn. | 2001 Nov 3 |
|
| Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production. | 2001 Oct |
|
| Hypocalcemia in the newborn. | 2001 Oct |
|
| Chemical mechanism of beta-xylosidase from Trichoderma reesei QM 9414: pH-dependence of kinetic parameters. | 2001 Oct |
|
| Considerations for optimal iron use for anemia due to chronic kidney disease. | 2001 Oct |
|
| Lack of allergic reaction to Ferrlecit in a patient with a history of severe pruritic reaction with INFeD. | 2001 Oct |
|
| Background osmolyte current involved in cell volume regulation of neuroblastoma x glioma hybrid NG108-15 cells. | 2001 Sep |
|
| On-line coupling of a miniaturized bioreactor with capillary electrophoresis, via a membrane interface, for monitoring the production of organic acids by microorganisms. | 2001 Sep |
|
| Intraoperative ultrasound and preoperative localization detects all occult insulinomas; discussion 1025-6. | 2001 Sep |
|
| Solubility and relative absorption of copper, iron, and zinc in two milk-based liquid infant formulae. | 2001 Sep |
|
| Hydrofluoric acid burn from a household rust remover. | 2001 Sep 3 |
|
| Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. | 2001 Sep-Oct |
|
| Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties. | 2001 Spring |
|
| Novel degradable polymers combining D-gluconic acid, a sugar of vegetal origin, with lactic and glycolic acids. | 2001 Winter |
|
| Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism. | 2002 Jan |
|
| In vitro study on the effects of iron sucrose, ferric gluconate and iron dextran on redox-active iron and oxidative stress. | 2010 |
|
| The available intravenous iron formulations: History, efficacy, and toxicology. | 2017 Jun |
|
| Oral sucrosomial iron versus intravenous iron in anemic cancer patients without iron deficiency receiving darbepoetin alfa: a pilot study. | 2017 Sep |
Patents
Sample Use Guides
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:49:58 GMT 2025
by
admin
on
Mon Mar 31 18:49:58 GMT 2025
|
| Record UNII |
QHP99G979J
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
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Preferred Name | English | ||
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Common Name | English | ||
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| Code System | Code | Type | Description | ||
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DTXSID401345067
Created by
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19222-41-4
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QHP99G979J
Created by
admin on Mon Mar 31 18:49:58 GMT 2025 , Edited by admin on Mon Mar 31 18:49:58 GMT 2025
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242-892-6
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admin on Mon Mar 31 18:49:58 GMT 2025 , Edited by admin on Mon Mar 31 18:49:58 GMT 2025
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25203
Created by
admin on Mon Mar 31 18:49:58 GMT 2025 , Edited by admin on Mon Mar 31 18:49:58 GMT 2025
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|---|---|---|---|---|
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PARENT -> SALT/SOLVATE | |||
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PARENT -> SALT/SOLVATE |
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