Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | 3C6H11O7.Fe.3H2O |
| Molecular Weight | 695.333 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 12 / 12 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.[Fe+3].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O
InChI
InChIKey=QUIAVNOOCZTWEL-AGRODQNPSA-K
InChI=1S/3C6H12O7.Fe.3H2O/c3*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;/h3*2-5,7-11H,1H2,(H,12,13);;3*1H2/q;;;+3;;;/p-3/t3*2-,3-,4+,5-;;;;/m111..../s1
| Molecular Formula | HO |
| Molecular Weight | 17.0073 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H12O7 |
| Molecular Weight | 196.1553 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | Fe |
| Molecular Weight | 55.845 |
| Charge | 3 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Sodium ferric gluconate complex (brand name Ferrlecit by Sanofi) is an intravenously administered iron product. Ferrlecit is an iron complex. It works by providing the body with its necessary level of iron. Ferric gluconate has been shown to be effective in dialysis
and non-dialysis associated anemia of chronic kidney
disease (CKD). It has also been shown to be effective in
improving responses to EPO in chemotherapy induced
anemia.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P02792|||Q9BTZ8 Gene ID: 2512.0 Gene Symbol: FTL Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Ferrlecit Approved UseFerrlecit is indicated for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Launch Date9.1929602E11 |
|||
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
12.9 μg/mL |
1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GLUCONATE ION plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
95 μg × h/mL |
1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GLUCONATE ION plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
2 h |
1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GLUCONATE ION plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Crystallization and preliminary X-ray crystallographic studies of recombinant thermoresistant gluconate kinase GntK from Escherichia coli. | 2001 Aug |
|
| Observations on amphotericin B treatment of kala-azar given in a rural set up in Bihar, India. | 2001 Jan |
|
| Identification of a new class of biopolymer: bacterial synthesis of a sulfur-containing polymer with thioester linkages. | 2001 Jan |
|
| Gluconobacter oxydans: its biotechnological applications. | 2001 Jul |
|
| Primary hypoparathyroidism in a cat complicated by suspect iatrogenic calcinosis cutis. | 2001 Jul-Aug |
|
| Organ heavy-metal accumulation during parenteral nutrition is associated with pathologic abnormalities in rats. | 2001 Jul-Aug |
|
| Significance of interferon-gamma in coronary artery bypass surgery. | 2001 Jul-Sep |
|
| Substrate selectivity of Gluconobacter oxydans for production of 2,5-diketo-D-gluconic acid and synthesis of 2-keto-L-gulonic acid in a multienzyme system. | 2001 Jun |
|
| A deeper investigation on carbohydrate cycling in Sinorhizobium meliloti. | 2001 Jun 15 |
|
| Heterologous expression of the acyl-acyl carrier protein thioesterase gene from the plant Umbellularia californica mediates polyhydroxyalkanoate biosynthesis in recombinant Escherichia coli. | 2001 Mar |
|
| Variation of enzyme activities at a branched pathway involved in the utilization of gluconate in Escherichia coli. | 2001 May |
|
| HCO3- potentiates the cAMP-dependent secretory response of the human distal colon through a DIDS-sensitive pathway. | 2001 May |
|
| Management of extravasation injuries. | 2001 May |
|
| Calcinosis cutis as a complication of parenteral calcium gluconate therapy. | 2001 May |
|
| Intraoperative ultrasound and preoperative localization detects all occult insulinomas; discussion 1025-6. | 2001 Sep |
|
| Solubility and relative absorption of copper, iron, and zinc in two milk-based liquid infant formulae. | 2001 Sep |
|
| Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties. | 2001 Spring |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:30:54 UTC 2023
by
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on
Sat Dec 16 05:30:54 UTC 2023
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| Record UNII |
W108RK810P
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| Record Status |
Validated (UNII)
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| Record Version |
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SUB13867MIG
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C035552
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23724828
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W108RK810P
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ANHYDROUS->SOLVATE | |||
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |