Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | 3C6H11O7.Fe |
| Molecular Weight | 641.287 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 12 / 12 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Fe+3].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O
InChI
InChIKey=CZNVSLGYWMSMKE-OPDGVEILSA-K
InChI=1S/3C6H12O7.Fe/c3*7-1-2(8)3(9)4(10)5(11)6(12)13;/h3*2-5,7-11H,1H2,(H,12,13);/q;;;+3/p-3/t3*2-,3-,4+,5-;/m111./s1
| Molecular Formula | C6H11O7 |
| Molecular Weight | 195.1473 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | Fe |
| Molecular Weight | 55.845 |
| Charge | 3 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Sodium ferric gluconate complex (brand name Ferrlecit by Sanofi) is an intravenously administered iron product. Ferrlecit is an iron complex. It works by providing the body with its necessary level of iron. Ferric gluconate has been shown to be effective in dialysis
and non-dialysis associated anemia of chronic kidney
disease (CKD). It has also been shown to be effective in
improving responses to EPO in chemotherapy induced
anemia.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P02792|||Q9BTZ8 Gene ID: 2512.0 Gene Symbol: FTL Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Ferrlecit Approved UseFerrlecit is indicated for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Launch Date9.1929602E11 |
|||
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
12.9 μg/mL |
1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GLUCONATE ION plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
95 μg × h/mL |
1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GLUCONATE ION plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
2 h |
1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GLUCONATE ION plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Adverse reactions associated with mobile therapeutic apheresis: analysis of 17,940 procedures. | 2001 |
|
| Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. | 2001 |
|
| Effects of P5, a novel oxazolo(3,2-a)pyridine derivative with a long-acting antihypertensive activity, on different agonist-mediated pressor responses in pithed rats. | 2001 Apr |
|
| Properties and modulation of alpha human atrial natriuretic peptide (alpha-hANP)-formed ion channels. | 2001 Aug |
|
| Electricity and the treatment of hydrofluoric acid burns--the wave of the future or a jolt from the past? | 2001 Aug |
|
| Iontophoretic delivery of calcium for experimental hydrofluoric acid burns. | 2001 Aug |
|
| Fatal unintentional occupational poisonings by hydrofluoric acid in the U.S. | 2001 Aug |
|
| Clinical features, tissue smear and competitive enzyme linked immunosorbent assay as dignostic and prognostic procedures for visceral leishmaniasis in Yemen. | 2001 Aug |
|
| Crystallization and preliminary X-ray crystallographic studies of recombinant thermoresistant gluconate kinase GntK from Escherichia coli. | 2001 Aug |
|
| Water-soluble adamantane-terminated dendrimers possessing a rhenium core. | 2001 Aug 10 |
|
| Post-natal ontogeny of stanniocalcin gene expression in rodent kidney and regulation by dietary calcium and phosphate. | 2001 Dec |
|
| Iron sucrose or ferric gluconate? | 2001 Dec |
|
| Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds. | 2001 Dec 1 |
|
| Cloning of a Serratia marcescens DNA fragment that induces quinoprotein glucose dehydrogenase-mediated gluconic acid production in Escherichia coli in the presence of stationary phase Serratia marcescens. | 2001 Dec 18 |
|
| Biosynthesis of poly(3-hydroxybutyrate-co-3-mercaptobutyrate) as a sulfur analogue to poly(3-hydroxybutyrate) (PHB). | 2001 Fall |
|
| Excipient-excipient interaction in the design of sustained-release theophylline tablets: in vitro and in vivo evaluation. | 2001 Jul |
|
| Cadmium in zinc-containing mineral supplements. | 2001 Jul |
|
| Effects of naloxone on calcium turnover in cows affected by milk fever. | 2001 Jul |
|
| Imaging and localization of pancreatic insulinomas. | 2001 Jul-Aug |
|
| Significance of interferon-gamma in coronary artery bypass surgery. | 2001 Jul-Sep |
|
| Substrate selectivity of Gluconobacter oxydans for production of 2,5-diketo-D-gluconic acid and synthesis of 2-keto-L-gulonic acid in a multienzyme system. | 2001 Jun |
|
| Single K+ channels in endocrine cells dispersed from the cricket (Gryllus bimaculatus) corpora allata. | 2001 Jun |
|
| Hypocalcaemia and hypomagnesaemia due to hydrofluoric acid. | 2001 Jun |
|
| Calcium L-edge XANES study of some calcium compounds. | 2001 Mar 1 |
|
| Aluminium toxicity and iron homeostasis. | 2001 Nov |
|
| Functional atrioventricular block in a preterm infant. | 2001 Nov |
|
| Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes. | 2001 Nov 1 |
|
| An atypical chemical burn. | 2001 Nov 3 |
|
| Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production. | 2001 Oct |
|
| Hypocalcemia in the newborn. | 2001 Oct |
|
| Chemical mechanism of beta-xylosidase from Trichoderma reesei QM 9414: pH-dependence of kinetic parameters. | 2001 Oct |
|
| Considerations for optimal iron use for anemia due to chronic kidney disease. | 2001 Oct |
|
| 99mTc-labeling experiments on CCK(4) by a direct method. | 2001 Oct |
|
| Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients. | 2001 Oct |
|
| Lack of allergic reaction to Ferrlecit in a patient with a history of severe pruritic reaction with INFeD. | 2001 Oct |
|
| Background osmolyte current involved in cell volume regulation of neuroblastoma x glioma hybrid NG108-15 cells. | 2001 Sep |
|
| On-line coupling of a miniaturized bioreactor with capillary electrophoresis, via a membrane interface, for monitoring the production of organic acids by microorganisms. | 2001 Sep |
|
| Thioglucosidase activity from Sphingobacterium sp. strain OTG1. | 2001 Sep |
|
| [Possible treatments of glottic spasm]. | 2001 Sep |
|
| Assessment of selective arterial calcium stimulation and hepatic venous sampling to localize insulin-secreting tumours. | 2001 Sep |
|
| Intraoperative ultrasound and preoperative localization detects all occult insulinomas; discussion 1025-6. | 2001 Sep |
|
| Solubility and relative absorption of copper, iron, and zinc in two milk-based liquid infant formulae. | 2001 Sep |
|
| CFTR modulates programmed cell death by decreasing intracellular pH in Chinese hamster lung fibroblasts. | 2001 Sep |
|
| Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry. | 2001 Sep 14 |
|
| Anion modulation of the slowly activating vacuolar channel. | 2001 Sep 15 |
|
| Hydrofluoric acid burn from a household rust remover. | 2001 Sep 3 |
|
| Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. | 2001 Sep-Oct |
|
| Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties. | 2001 Spring |
|
| Novel degradable polymers combining D-gluconic acid, a sugar of vegetal origin, with lactic and glycolic acids. | 2001 Winter |
|
| Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism. | 2002 Jan |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:59:27 UTC 2023
by
admin
on
Sat Dec 16 08:59:27 UTC 2023
|
| Record UNII |
C613TM6I6V
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
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| Code System | Code | Type | Description | ||
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300000022113
Created by
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656646
Created by
admin on Sat Dec 16 08:59:27 UTC 2023 , Edited by admin on Sat Dec 16 08:59:27 UTC 2023
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38658-53-6
Created by
admin on Sat Dec 16 08:59:27 UTC 2023 , Edited by admin on Sat Dec 16 08:59:27 UTC 2023
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C613TM6I6V
Created by
admin on Sat Dec 16 08:59:27 UTC 2023 , Edited by admin on Sat Dec 16 08:59:27 UTC 2023
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254-064-1
Created by
admin on Sat Dec 16 08:59:27 UTC 2023 , Edited by admin on Sat Dec 16 08:59:27 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
SOLVATE->ANHYDROUS |
