Sodium gluconate

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H11O7.Na
Molecular Weight	218.1371
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=UPMFZISCCZSDND-JJKGCWMISA-M

InChI=1S/C6H12O7.Na/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);/q;+1/p-1/t2-,3-,4+,5-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C6H11O7
Molecular Weight	195.1473
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/cdi/ferrlecit.html | https://www.ncbi.nlm.nih.gov/pubmed/28371203http://hrcak.srce.hr/file/161891

Gluconic acid is a natural compound produced from glucose through a simple dehydrogenation reaction catalysed by glucose oxidase. Gluconic acid and its salts are used in the formulation of food, pharmaceutical and hygienic products.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Ferritin light chain 6 Target ID: P02792\|\|\|Q9BTZ8 Gene ID: 2512.0 Gene Symbol: FTL Target Organism: Homo sapiens (Human) Sources: https://www.drugbank.ca/drugs/DB09517	Binding Agent 1076

Conditions

Condition	Modality	Targets	Highest Phase	Product
Iron deficiency anemia 52 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28391437 https://www.ncbi.nlm.nih.gov/pubmed/26385819 https://www.ncbi.nlm.nih.gov/pubmed/21304025	Primary		Approved 8583	Ferrlecit Approved Use Ferrlecit is indicated for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Launch Date 1999
Unknown 2596

C_max

Value	Dose	Co-administered	Analyte	Population
12.9 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
95 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
2 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 2252	inhibitor 2438		inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP2C19 2057 CYP1A2 2153 CYP19A1 429

Drug as perpetrator

Target	Modality	Activity
CYP2C9 2497	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1671198#sid=144209943	inconclusive [IC50 35.5162 uM]
CYP1A2 2333	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1671199#sid=144209943	inconclusive [IC50 63.1577 uM]
CYP19A1 430	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/743139#sid=144209943	no
CYP3A4 2633	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1671201#sid=144209943	no
CYP2C19 2141	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1671197#sid=144209943	yes [IC50 89.2126 uM]

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1671200#sid=144209943

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-034998	http://www.3bsc.com/index/pro_info.php?id=56931
AA Blocks	AA00I9C2	https://www.aablocks.com/goods/Goods/detail?id=AA00I9C2
Aaron Chemicals	AR00IA3U	http://www.aaronchem.com/526-95-4
abcr GmbH	AB116914	http://www.abcr.com/shop/en/AB116914
Acadechem	ACDS-070451	http://www.acadechemical.com/product/145150
Achemtek	0104-021202	http://www.achemtek.com/526-95-4
Acros Organics	AC119890010	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics/AC119890010
Acros Organics	AC119890025	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics/AC119890025
Acros Organics	AC119890100	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics-2/AC119890100
AHH Chemical co.,ltd	MT-52123	http://www.ahhchemical.com/product/MT-52123.html
AK Scientific, Inc. (AKSCI)	V2121	http://www.aksci.com/item_detail.php?cat=V2121
Alfa Aesar	A16806	https://www.alfa.com/en/catalog/A16806/
Alfa Chemistry	157663-13-3	https://www.alfa-chemistry.com/cas_157663-13-3.htm
Angene	AGN-PC-0WADE6	http://www.angenechemical.com/productshow/AGN-PC-0WADE6.html
Aurora Fine Chemicals LLC	A13.111.613	http://online.aurorafinechemicals.com/info?ID=A13.111.613
Avantor Inc	200012-582	https://us.vwr.com/store/product/7516629/sodium-d-gluconate
Avantor Inc	700006-244	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
Avantor Inc	700006-248	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
Avantor Inc	700006-250	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
BioSynth	W-109086	https://www.biosynth.com/en/products/life-science/other-biochemicals/products/W-109086.html
BLD Pharm	BD305849	http://www.bldpharm.com/products/526-95-4.html
Chem Scene	CS-0015343	http://www.chemscene.com/526-95-4.html
Chemspace	CSSB00016994743	https://chem-space.com/CSSB00016994743
Hairui	HR101553	http://www.hairuichem.com/en/product/526-95-4.html
iChemical	EBD72662	http://www.ichemical.com/products/526-95-4.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Lab Network	LN00195400	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00195400
Matrix Scientific	99017	https://www.matrixscientific.com/099017.html
MedChem Express	HY-Y0569	https://www.medchemexpress.com/D-Gluconic_acid.html
MuseChem	M102068	https://www.musechem.com/product/M102068.html
MuseChem	R030627	https://www.musechem.com/product/R030627.html
Oakwood	240908	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=121907&ExtHyperLink=1
Oakwood	98946	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=161824&ExtHyperLink=1
Selleck Chemicals	S3595	http://www.selleckchem.com/products/d-gluconic-acid.html
Sigma-Aldrich	12-0635_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/120635?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	G1951_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/g1951?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S054794	http://www.sinfoobiotech.com/product/1058192
Smolecule	S576289	https://www.smolecule.com/products/s576289
TCI (Tokyo Chemical Industry)	G0036	http://www.tcichemicals.com/eshop/en/us/commodity/G0036/index.html
TCI (Tokyo Chemical Industry)	G0038	http://www.tcichemicals.com/eshop/en/us/commodity/G0038/index.html
THE BioTek	bt-432274	https://www.thebiotek.com/product/others/bt-432274
VladaChem	VL279528-25G	https://www.vladachem.com/product.php?products=526-95-4

PubMed

Title	Date	PubMed
Oral sucrosomial iron versus intravenous iron in anemic cancer patients without iron deficiency receiving darbepoetin alfa: a pilot study.	2017-09	28391437
The available intravenous iron formulations: History, efficacy, and toxicology.	2017-06	28371203
In vitro study on the effects of iron sucrose, ferric gluconate and iron dextran on redox-active iron and oxidative stress.	2010	20712137
Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism.	2002-01	11746779
Cloning of a Serratia marcescens DNA fragment that induces quinoprotein glucose dehydrogenase-mediated gluconic acid production in Escherichia coli in the presence of stationary phase Serratia marcescens.	2001-12-18	11750805
Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds.	2001-12-01	11692298
Iron sucrose or ferric gluconate?	2001-12	11728988
Post-natal ontogeny of stanniocalcin gene expression in rodent kidney and regulation by dietary calcium and phosphate.	2001-12	11737588
An atypical chemical burn.	2001-11-03	11705565
Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes.	2001-11-01	11597353
Aluminium toxicity and iron homeostasis.	2001-11	11709207
Functional atrioventricular block in a preterm infant.	2001-11	11668169
Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production.	2001-10	11759685
Hypocalcemia in the newborn.	2001-10	11758136
Chemical mechanism of beta-xylosidase from Trichoderma reesei QM 9414: pH-dependence of kinetic parameters.	2001-10	11728634
Considerations for optimal iron use for anemia due to chronic kidney disease.	2001-10	11726002
99mTc-labeling experiments on CCK(4) by a direct method.	2001-10	11578909
Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients.	2001-10	11576360
Lack of allergic reaction to Ferrlecit in a patient with a history of severe pruritic reaction with INFeD.	2001-10	11549911
Imaging and localization of pancreatic insulinomas.	2001-09-22	11566091
Anion modulation of the slowly activating vacuolar channel.	2001-09-15	11562795
Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry.	2001-09-14	11587333
Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans.	2001-09-11	11550076
Significance of interferon-gamma in coronary artery bypass surgery.	2001-09-11	11548832
Hydrofluoric acid burn from a household rust remover.	2001-09-03	11587261
Background osmolyte current involved in cell volume regulation of neuroblastoma x glioma hybrid NG108-15 cells.	2001-09	11765218
On-line coupling of a miniaturized bioreactor with capillary electrophoresis, via a membrane interface, for monitoring the production of organic acids by microorganisms.	2001-09	11678187
Thioglucosidase activity from Sphingobacterium sp. strain OTG1.	2001-09	11601617
[Possible treatments of glottic spasm].	2001-09	11593774
Assessment of selective arterial calcium stimulation and hepatic venous sampling to localize insulin-secreting tumours.	2001-09	11589679
Intraoperative ultrasound and preoperative localization detects all occult insulinomas; discussion 1025-6.	2001-09	11529824
Solubility and relative absorption of copper, iron, and zinc in two milk-based liquid infant formulae.	2001-09	11517734
CFTR modulates programmed cell death by decreasing intracellular pH in Chinese hamster lung fibroblasts.	2001-09	11502558
Water-soluble adamantane-terminated dendrimers possessing a rhenium core.	2001-08-10	11485462
Properties and modulation of alpha human atrial natriuretic peptide (alpha-hANP)-formed ion channels.	2001-08	11558674
Electricity and the treatment of hydrofluoric acid burns--the wave of the future or a jolt from the past?	2001-08	11505153
Iontophoretic delivery of calcium for experimental hydrofluoric acid burns.	2001-08	11505130
Fatal unintentional occupational poisonings by hydrofluoric acid in the U.S.	2001-08	11494350
Clinical features, tissue smear and competitive enzyme linked immunosorbent assay as dignostic and prognostic procedures for visceral leishmaniasis in Yemen.	2001-08	11478434
Excipient-excipient interaction in the design of sustained-release theophylline tablets: in vitro and in vivo evaluation.	2001-07	11548856
Cadmium in zinc-containing mineral supplements.	2001-07	11474903
Substrate selectivity of Gluconobacter oxydans for production of 2,5-diketo-D-gluconic acid and synthesis of 2-keto-L-gulonic acid in a multienzyme system.	2001-06	11563824
Single K+ channels in endocrine cells dispersed from the cricket (Gryllus bimaculatus) corpora allata.	2001-06	11497122
Effects of P5, a novel oxazolo(3,2-a)pyridine derivative with a long-acting antihypertensive activity, on different agonist-mediated pressor responses in pithed rats.	2001-04	11679017
Calcium L-edge XANES study of some calcium compounds.	2001-03-01	11512744
Novel degradable polymers combining D-gluconic acid, a sugar of vegetal origin, with lactic and glycolic acids.	2001	11777404
Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties.	2001	11749154
Adverse reactions associated with mobile therapeutic apheresis: analysis of 17,940 procedures.	2001	11746539
Biosynthesis of poly(3-hydroxybutyrate-co-3-mercaptobutyrate) as a sulfur analogue to poly(3-hydroxybutyrate) (PHB).	2001	11710011
Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris.	2001	11586012

Patents

Sample Use Guides

In Vivo Use Guide

8 weeks of IV ferric gluconate 125 mg weekly

Route of Administration: Intravenous

In Vitro Use Guide

The effect of iron(III)-gluconate (Ferlixit) at various concentrations on the malondialdehyde production in isolated rat liver mitochondria was studied. Concentratiors of iron as low as 100 uM are able to elicit a significant enhancement of lipid peroxidation. process.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:36:48 GMT 2025` Edited by `admin` on `Mon Mar 31 17:36:48 GMT 2025`
Record UNII	R6Q3791S76
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLUCONATE SODIUM

Preferred Name

English

Sodium gluconate

Official Name

English

E576

Common Name

English

D-GLUCONIC ACID, SODIUM SALT (1:1)

Common Name

English

Gluconate sodium [WHO-DD]

Common Name

English

SODIUM GLUCONATE [VANDF]

Common Name

English

D-GLUCONIC ACID, MONOSODIUM SALT

Common Name

English

CLEWAT GL

Brand Name

English

SODIUM D-GLUCONATE

Common Name

English

NSC-759599

Code

English

NATRUM GLUCONICUM

Common Name

English

SODIUM GLUCONATE [II]

Common Name

English

MONOSODIUM GLUCONATE

Common Name

English

SODIUM GLUCONATE [MART.]

Common Name

English

E-576

Common Name

English

INS-576

Code

English

SODIUM GLUCONATE [USP MONOGRAPH]

Common Name

English

INS NO.576

Code

English

GLUCONIC ACID, MONOSODIUM SALT, D-

Common Name

English

SODIUM GLUCONATE [ORANGE BOOK]

Common Name

English

E-576-

Code

English

SODIUM GLUCONATE [FCC]

Common Name

English

FEMA NO. 4934

Code

English

HELSHAS A

Common Name

English

GLUCONIC ACID SODIUM SALT

Common Name

English

GLUCONIC ACID SODIUM SALT [MI]

Common Name

English

BVD ADDICRETE

Brand Name

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-576