U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula 2C6H11O7.Fe.2H2O
Molecular Weight 482.17
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERROUS GLUCONATE

SMILES

O.O.[Fe++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=OKGNXSFAYMSVNN-SYAJEJNSSA-L
InChI=1S/2C6H12O7.Fe.2H2O/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;/h2*2-5,7-11H,1H2,(H,12,13);;2*1H2/q;;+2;;/p-2/t2*2-,3-,4+,5-;;;/m11.../s1

HIDE SMILES / InChI
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Fe
Molecular Weight 55.845
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C6H12O7
Molecular Weight 196.1553
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3541174 | https://books.google.ru/books?id=7mxyBgAAQBAJ&pg=PA13&lpg=PA13&dq=%22ferrous+iodide%22+anemia&source=bl&ots=ZGyFhUiJZ4&sig=IZOhRVaGmlwX7GcqgoE6rnCsCa4&hl=ru&sa=X&ved=0ahUKEwjYu7PCyYHUAhWiQpoKHR6cCfcQ6AEIUjAJ#v=onepage&q=%22ferrous%20iodide%22&f=false

There is no information about biological and pharmacological application of Iron(II) fluoride (also known as ferrous fluoride). It is known, that this substance is used to catalyze some organic reactions.

Originator

Approval Year

1921
1468
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Not Provided
511
Unknown

Approved Use

Unknown
Palliative
Not Provided
511
Unknown

Approved Use

Unknown
Primary
Approved
8583
Ferro Sanol Duodenal

Approved Use

Ferro Sanol is an iron substitute in case of latent or manifest iron deficiency with and without development of anaemia.
Curative
Approved
8583
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
PubMed

PubMed

TitleDatePubMed
Reactivity enhancement of iron sulfide nanoparticles stabilized by sodium alginate: Taking Cr (VI) removal as an example.
2017-07-05
Continuous sulfidogenic wastewater treatment with iron sulfide sludge oxidation and recycle.
2017-05-01
Atomic Layer Deposition of Iron Sulfide and Its Application as a Catalyst in the Hydrogenation of Azobenzenes.
2017-03-13
Synthesis of phosphabenzenes by an iron-catalyzed [2+2+2] cycloaddition reaction of diynes with phosphaalkynes.
2015-06-22
A practical and successful desensitization protocol for immediate hypersensitivity reactions to iron salts.
2014
Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows.
2013-07
Tolerability of different oral iron supplements: a systematic review.
2013-04
Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: Risk factors for early atherosclerosis.
2011-06-10
The effect of iron treatment on adhesion molecules in patients with iron deficiency anemia.
2010-12
Bioleaching of heavy metals from sewage sludge by indigenous iron-oxidizing microorganisms using ammonium ferrous sulfate and ferrous sulfate as energy sources: a comparative study.
2009-11-15
Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice.
2009
Decreased treatment failure rates following duodenal release ferrous glycine sulfate in iron deficiency anemia associated with autoimmune gastritis and Helicobacter pylori gastritis.
2007
Determination of water in ferrous lactate by near infrared reflectance spectroscopy with a fibre-optic probe.
1997-10
[Historical notes on the therapy of depression].
1986-11-22
[FERROUS ASPARTATE IN THERAPY].
1964-01-01
Clinical appraisal of drugs with special reference to a new chelate hematinic.
1957-07-11
[Ferrous lactate as an oral iron preparation for therapeutic use].
1954-11-27
THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA.
1937-07
FERROUS IODIDE AND LINOLEIC ACID IN VITAMIN A DEFICIENCY. A REPLY TO CERTAIN CRITICISMS.
1932-11-11
THE ADMINISTRATION OF FERROUS IODIDE AND LINOLEIC ACID TO RATS DEPRIVED OF VITAMIN A.
1932-09-30
FERROUS IODIDE AS A SUBSTITUTE FOR VITAMIN A IN RATS.
1932-07-01
Patents

Patents

CN105565963
37
US20020127665
37
US2009028810
37
US20150202224
37
US2877253
37
US3091626
37
US5534268
37
US6407138
37
US8080520
37
US8802114
37

Sample Use Guides

In Vivo Use Guide
Adults should usually take one capsule a day. In cases of pronounced iron deficiency, adults can be given a dosage 2 to 3 times higher at the beginning of therapy. A daily dose of more than 5 mg Fe2+/kg body weight should in-well founded exceptional cases not be exceeded.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:45:49 GMT 2025
Edited
by admin
on Mon Mar 31 17:45:49 GMT 2025
Record UNII
U1B11I423Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERROUS GLUCONATE DIHYDRATE
MI  
Preferred Name English
FERROUS GLUCONATE
EP   FCC   INCI   MART.   USP   VANDF   WHO-DD  
INCI  
Official Name English
IRON (AS FERROUS GLUCONATE) [VANDF]
Common Name English
IRON(II) GLUCONATE
Common Name English
E-579
Code English
FERROUS GLUCONATE [EP IMPURITY]
Common Name English
INS NO.579
Code English
Ferrous gluconate [WHO-DD]
Common Name English
D-GLUCONIC ACID, IRON(II) SALT (2:1), DIHYDRATE
Common Name English
FERGON
Brand Name English
FERROUS GLUCONATE [MART.]
Common Name English
IRON, BIS(D-GLUCONATO-.KAPPA.O1,.KAPPA.O2)-, HYDRATE (1:2)
Systematic Name English
IRON GLUCONATE
Common Name English
Ferrous gluconate dihydrate [WHO-DD]
Common Name English
IRON (II) DI-D-GLUCONATE DEHYDRATE
Common Name English
FERROUS GLUCONATE [FCC]
Common Name English
FERROUS GLUCONATE [VANDF]
Common Name English
IRON(II) GLUCONATE (1:2) DIHYDRATE
Common Name English
D-GLUCONIC ACID, IRON(2+) SALT, DIHYDRATE
Systematic Name English
D-GLUCONIC ACID, IRON(2+) SALT, HYDRATE (2:1:2)
Systematic Name English
FERROUS GLUCONATE DIHYDRATE [MI]
Common Name English
GLUCONIC ACID, IRON(2+) SALT, DIHYDRATE, D-
Systematic Name English
FERROUS GLUCONATE [USP MONOGRAPH]
Common Name English
INS-579
Code English
FERROUS-GLUCONATE
Common Name English
Classification Tree Code System Code
WHO-VATC QB03AA03
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
JECFA EVALUATION INS-579
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
CODEX ALIMENTARIUS (GSFA) INS-579
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
CFR 21 CFR 184.1308
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
WHO-ATC B03AA03
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
Code System Code Type Description
RXCUI
24942
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY RxNorm
SMS_ID
100000138196
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
MESH
C011819
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
CONCEPT Dietary Supplement
EVMPD
SUB13867MIG
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
DRUG CENTRAL
4491
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
MERCK INDEX
m5344
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY Merck Index
CAS
22830-45-1
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
ALTERNATIVE
EVMPD
SUB77590
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
DRUG BANK
DB14488
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
PUBCHEM
198008
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
EPA CompTox
DTXSID601018448
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
CAS
12389-15-0
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
SUPERSEDED
CAS
6047-12-7
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
DAILYMED
U1B11I423Z
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
FDA UNII
U1B11I423Z
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
NCI_THESAURUS
C29048
Created by admin on Mon Mar 31 17:45:49 GMT 2025 , Edited by admin on Mon Mar 31 17:45:49 GMT 2025
PRIMARY
Related Record Type Details
Structure of FERROUS CATION
PARENT -> SALT/SOLVATE
Structure of Gluconic Acid
PARENT -> SALT/SOLVATE
Structure of FERROUS GLUCONATE ANHYDROUS
ANHYDROUS->SOLVATE
Related Record Type Details
Structure of FERROUS CATION
ACTIVE MOIETY
NIH
NCATS
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DISCLAIMER
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