FERROUS GLUCONATE

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C6H11O7.Fe.2H2O
Molecular Weight	482.17
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.[Fe++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=OKGNXSFAYMSVNN-SYAJEJNSSA-L

InChI=1S/2C6H12O7.Fe.2H2O/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;/h2*2-5,7-11H,1H2,(H,12,13);;2*1H2/q;;+2;;/p-2/t2*2-,3-,4+,5-;;;/m11.../s1

HIDE SMILES / InChI

Molecular Formula	Fe
Molecular Weight	55.845
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H12O7
Molecular Weight	196.1553
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14116934http://www.foodchemadditives.com/products/Ferrous-Lactatehttp://nj.gov/health/eoh/rtkweb/documents/fs/0928.pdfDOI: 10.1021/ja00949a016 Retrived from http://pubs.acs.org/doi/abs/10.1021/ja00949a016https://www.drugs.com/inactive/ferrous-oxide-389.htmlhttp://www.druglead.com/cds/ferrous-iodide.htmlhttp://www.drugfuture.com/chemdata/ferroglycine-sulfate.htmlhttps://www.ncbi.nlm.nih.gov/pubmed/16694502
Curator's Comment: description was created based on several sources, including http://www.minapharm.com/Public/ProductDetails.aspx?ProductCode=FERRO_SANO&langParam=en

Iron(II) gluconate (also known as a ferrous gluconate) is used in the treatment of hypochromic anemia. The real problem of iron therapy is not the theoretical utilization of iron, or the reticulocyte response, or even the daily increase of hemoglobin. These are important only as they indicate the return of the patients' blood to normal in a reasonably short time without undue inconvenience. Most patients suffering from hypochromic anemia respond well to most forms of iron when administered in adequate dosage. For the patients who cannot tolerate the usual iron compounds, it is important to have a medication which is effective and which causes minimum disturbance. Ferrous gluconate is such a medicament.

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Anemia 68 Sources: http://www.medicatione.com/?c=ing&s=ferrous%20aspartate	Palliative	Not Provided 504	Unknown Approved Use Unknown
Unknown 2578
Hypochromic anemia 36 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16694502	Palliative	Not Provided 504	Unknown Approved Use Unknown
Unknown 2578
Unknown 2578
Unknown 2578
Iron deficiency 80 Sources: http://www.minapharm.com/Public/ProductDetails.aspx?ProductCode=FERRO_SANO&langParam=en	Primary	Approved 8429	Ferro Sanol Duodenal Approved Use Ferro Sanol is an iron substitute in case of latent or manifest iron deficiency with and without development of anaemia.
Unknown 2578

PubMed

Title	Date	PubMed
THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA.	1937 Jul	16694502
Clinical appraisal of drugs with special reference to a new chelate hematinic.	1957 Jul 11	13452048
[FERROUS ASPARTATE IN THERAPY].	1964 Jan 1	14116934
Determination of water in ferrous lactate by near infrared reflectance spectroscopy with a fibre-optic probe.	1997 Oct	9408841
Decreased treatment failure rates following duodenal release ferrous glycine sulfate in iron deficiency anemia associated with autoimmune gastritis and Helicobacter pylori gastritis.	2007	17426393
Bioleaching of heavy metals from sewage sludge by indigenous iron-oxidizing microorganisms using ammonium ferrous sulfate and ferrous sulfate as energy sources: a comparative study.	2009 Nov 15	19586718
The effect of iron treatment on adhesion molecules in patients with iron deficiency anemia.	2010 Dec	20039148

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:05:04 UTC 2023` Edited by `admin` on `Fri Dec 15 15:05:04 UTC 2023`
Record UNII	U1B11I423Z
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FERROUS GLUCONATE

Official Name

English

IRON (AS FERROUS GLUCONATE) [VANDF]

Common Name

English

FERROUS GLUCONATE DIHYDRATE

Common Name

English

IRON(II) GLUCONATE

Common Name

English

E-579

Code

English

FERROUS GLUCONATE [EP IMPURITY]

Common Name

English

INS NO.579

Code

English

Ferrous gluconate [WHO-DD]

Common Name

English

D-GLUCONIC ACID, IRON(II) SALT (2:1), DIHYDRATE

Common Name

English

FERGON

Brand Name

English

FERROUS GLUCONATE [MART.]

Common Name

English

IRON, BIS(D-GLUCONATO-.KAPPA.O1,.KAPPA.O2)-, HYDRATE (1:2)

Systematic Name

English

IRON GLUCONATE

Common Name

English

Ferrous gluconate dihydrate [WHO-DD]

Common Name

English

IRON (II) DI-D-GLUCONATE DEHYDRATE

Common Name

English

FERROUS GLUCONATE [FCC]

Common Name

English

FERROUS GLUCONATE [VANDF]

Common Name

English

IRON(II) GLUCONATE (1:2) DIHYDRATE

Common Name

English

FERROUS GLUCONATE [INCI]

Common Name

English

D-GLUCONIC ACID, IRON(2+) SALT, DIHYDRATE

Systematic Name

English

D-GLUCONIC ACID, IRON(2+) SALT, HYDRATE (2:1:2)

Systematic Name

English

FERROUS GLUCONATE DIHYDRATE [MI]

Common Name

English

GLUCONIC ACID, IRON(2+) SALT, DIHYDRATE, D-

Systematic Name

English

FERROUS GLUCONATE [USP MONOGRAPH]

Common Name

English

INS-579

Code

English

FERROUS-GLUCONATE

Common Name

English

Classification Tree Code System Code

WHO-VATC

QB03AA03