U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula 2C6H11O7.Fe.2H2O
Molecular Weight 482.17
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERROUS GLUCONATE

SMILES

O.O.[Fe++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=OKGNXSFAYMSVNN-SYAJEJNSSA-L
InChI=1S/2C6H12O7.Fe.2H2O/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;/h2*2-5,7-11H,1H2,(H,12,13);;2*1H2/q;;+2;;/p-2/t2*2-,3-,4+,5-;;;/m11.../s1

HIDE SMILES / InChI
Molecular Formula Fe
Molecular Weight 55.845
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C6H12O7
Molecular Weight 196.1553
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including http://www.minapharm.com/Public/ProductDetails.aspx?ProductCode=FERRO_SANO&langParam=en

Iron(II) gluconate (also known as a ferrous gluconate) is used in the treatment of hypochromic anemia. The real problem of iron therapy is not the theoretical utilization of iron, or the reticulocyte response, or even the daily increase of hemoglobin. These are important only as they indicate the return of the patients' blood to normal in a reasonably short time without undue inconvenience. Most patients suffering from hypochromic anemia respond well to most forms of iron when administered in adequate dosage. For the patients who cannot tolerate the usual iron compounds, it is important to have a medication which is effective and which causes minimum disturbance. Ferrous gluconate is such a medicament.

Originator

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Not Provided
504
Unknown

Approved Use

Unknown
Palliative
Not Provided
504
Unknown

Approved Use

Unknown
Primary
Approved
8429
Ferro Sanol Duodenal

Approved Use

Ferro Sanol is an iron substitute in case of latent or manifest iron deficiency with and without development of anaemia.
PubMed

PubMed

TitleDatePubMed
FERROUS IODIDE AS A SUBSTITUTE FOR VITAMIN A IN RATS.
1932 Jul 1
FERROUS IODIDE AND LINOLEIC ACID IN VITAMIN A DEFICIENCY. A REPLY TO CERTAIN CRITICISMS.
1932 Nov 11
THE ADMINISTRATION OF FERROUS IODIDE AND LINOLEIC ACID TO RATS DEPRIVED OF VITAMIN A.
1932 Sep 30
THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA.
1937 Jul
[Ferrous lactate as an oral iron preparation for therapeutic use].
1954 Nov 27
Clinical appraisal of drugs with special reference to a new chelate hematinic.
1957 Jul 11
[FERROUS ASPARTATE IN THERAPY].
1964 Jan 1
[Historical notes on the therapy of depression].
1986 Nov 22
Determination of water in ferrous lactate by near infrared reflectance spectroscopy with a fibre-optic probe.
1997 Oct
Decreased treatment failure rates following duodenal release ferrous glycine sulfate in iron deficiency anemia associated with autoimmune gastritis and Helicobacter pylori gastritis.
2007
Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice.
2009
Bioleaching of heavy metals from sewage sludge by indigenous iron-oxidizing microorganisms using ammonium ferrous sulfate and ferrous sulfate as energy sources: a comparative study.
2009 Nov 15
The effect of iron treatment on adhesion molecules in patients with iron deficiency anemia.
2010 Dec
Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: Risk factors for early atherosclerosis.
2011 Jun 10
Tolerability of different oral iron supplements: a systematic review.
2013 Apr
Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows.
2013 Jul
A practical and successful desensitization protocol for immediate hypersensitivity reactions to iron salts.
2014
Synthesis of phosphabenzenes by an iron-catalyzed [2+2+2] cycloaddition reaction of diynes with phosphaalkynes.
2015 Jun 22
Reactivity enhancement of iron sulfide nanoparticles stabilized by sodium alginate: Taking Cr (VI) removal as an example.
2017 Jul 5
Atomic Layer Deposition of Iron Sulfide and Its Application as a Catalyst in the Hydrogenation of Azobenzenes.
2017 Mar 13
Continuous sulfidogenic wastewater treatment with iron sulfide sludge oxidation and recycle.
2017 May 1
Patents

Patents

CN105565963
36
US20020127665
36
US2009028810
36
US20150202224
36
US2877253
36
US3091626
36
US5534268
36
US6407138
36
US8080520
36
US8802114
36

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:05:04 GMT 2023
Edited
by admin
on Fri Dec 15 15:05:04 GMT 2023
Record UNII
U1B11I423Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERROUS GLUCONATE
EP   FCC   INCI   MART.   USP   VANDF   WHO-DD  
INCI  
Official Name English
IRON (AS FERROUS GLUCONATE) [VANDF]
Common Name English
FERROUS GLUCONATE DIHYDRATE
MI  
Common Name English
IRON(II) GLUCONATE
Common Name English
E-579
Code English
FERROUS GLUCONATE [EP IMPURITY]
Common Name English
INS NO.579
Code English
Ferrous gluconate [WHO-DD]
Common Name English
D-GLUCONIC ACID, IRON(II) SALT (2:1), DIHYDRATE
Common Name English
FERGON
Brand Name English
FERROUS GLUCONATE [MART.]
Common Name English
IRON, BIS(D-GLUCONATO-.KAPPA.O1,.KAPPA.O2)-, HYDRATE (1:2)
Systematic Name English
IRON GLUCONATE
Common Name English
Ferrous gluconate dihydrate [WHO-DD]
Common Name English
IRON (II) DI-D-GLUCONATE DEHYDRATE
Common Name English
FERROUS GLUCONATE [FCC]
Common Name English
FERROUS GLUCONATE [VANDF]
Common Name English
IRON(II) GLUCONATE (1:2) DIHYDRATE
Common Name English
FERROUS GLUCONATE [INCI]
Common Name English
D-GLUCONIC ACID, IRON(2+) SALT, DIHYDRATE
Systematic Name English
D-GLUCONIC ACID, IRON(2+) SALT, HYDRATE (2:1:2)
Systematic Name English
FERROUS GLUCONATE DIHYDRATE [MI]
Common Name English
GLUCONIC ACID, IRON(2+) SALT, DIHYDRATE, D-
Systematic Name English
FERROUS GLUCONATE [USP MONOGRAPH]
Common Name English
INS-579
Code English
FERROUS-GLUCONATE
Common Name English
Classification Tree Code System Code
WHO-VATC QB03AA03
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
JECFA EVALUATION INS-579
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-579
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
CFR 21 CFR 184.1308
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
WHO-ATC B03AA03
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
Code System Code Type Description
RXCUI
24942
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY RxNorm
SMS_ID
100000138196
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
MESH
C011819
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
CONCEPT Dietary Supplement
EVMPD
SUB13867MIG
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
DRUG CENTRAL
4491
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
MERCK INDEX
m5344
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY Merck Index
CAS
22830-45-1
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
ALTERNATIVE
EVMPD
SUB77590
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
DRUG BANK
DB14488
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
PUBCHEM
198008
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
EPA CompTox
DTXSID20924633
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
CAS
12389-15-0
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
SUPERSEDED
CAS
6047-12-7
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
DAILYMED
U1B11I423Z
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
FDA UNII
U1B11I423Z
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
NCI_THESAURUS
C29048
Created by admin on Fri Dec 15 15:05:04 GMT 2023 , Edited by admin on Fri Dec 15 15:05:04 GMT 2023
PRIMARY
Related Record Type Details
Structure of FERROUS CATION
PARENT -> SALT/SOLVATE
Structure of GLUCONIC ACID
PARENT -> SALT/SOLVATE
Structure of FERROUS GLUCONATE ANHYDROUS
ANHYDROUS->SOLVATE
Related Record Type Details
Structure of FERROUS CATION
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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