SODIUM ANTIMONYLGLUCONATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H8O7.Na.Sb
Molecular Weight	336.873
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Sb+3].OC[C@@H]([O-])[C@@H]([O-])[C@H]([O-])[C@@H](O)C([O-])=O

InChI

InChIKey=JEKOQEIHGHQVEI-ZBHRUSISSA-M

InChI=1S/C6H9O7.Na.Sb/c7-1-2(8)3(9)4(10)5(11)6(12)13;;/h2-5,7,11H,1H2,(H,12,13);;/q-3;+1;+3/p-1/t2-,3-,4+,5-;;/m1../s1

HIDE SMILES / InChI

Molecular Formula	C6H8O7
Molecular Weight	192.1235
Charge	-4
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Sb
Molecular Weight	121.76
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14287627 | https://www.ncbi.nlm.nih.gov/pubmed/14128585 | https://www.ncbi.nlm.nih.gov/pubmed/14433281 | https://www.ncbi.nlm.nih.gov/pubmed/13187569

Sodium antimonylgluconate (triostam) is a trivalent antimony compound. It was used for the treatment of schistosomiasis. Usually given intravenously.

Approval Year

Targets

Primary Target	Pharmacology	Potency
Trypanothione reductase 5 Target ID: CHEMBL2176840 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7607216	Inhibitor 8297
Glutathione reductase 11 Target ID: CHEMBL2755 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7607216	Inhibitor 8297
ATP-dependent 6-phosphofructokinase 21 Target ID: Q27778 Gene ID: NA Gene Symbol: PFK Target Organism: Schistosoma mansoni (Blood fluke) Sources: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332489	Inhibitor 8297	200.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Leishmaniasis 20 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5302298 https://www.ncbi.nlm.nih.gov/pubmed/14287627 https://www.ncbi.nlm.nih.gov/pubmed/14287627	Curative		Approved 8429	TRIOSTAM Approved Use For the treatment of various types of a protozoal infection called leishmaniasis.

PubMed

Title	Date	PubMed
Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.	1995 Jun 1	7607216

Patents

Sample Use Guides

In Vivo Use Guide

The drug should be used at a total dosage not exceeding 25 mg. per kg. and a daily dosage not exceeding 6 mg. per kg.,

Route of Administration: Intravenous

In Vitro Use Guide

Both L. donovani trypanothione reductase and human erythrocyte glutathione reductase are inhibited by Sodium antimonylgluconate (5-100uM) in a timedependent manner.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:51:51 UTC 2023` Edited by `admin` on `Fri Dec 15 15:51:51 UTC 2023`
Record UNII	1U72RT57II
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM ANTIMONYLGLUCONATE

Common Name

English

SODIUM SALT OF A TRIVALENT ANTIMONY DERIVATIVE OF GLUCONIC ACID

Common Name

English

SODIUM ANTIMONY GLUCONATE

Common Name

English

TRIOSTAM

Brand Name

English

ANTIMONY SODIUM GLUCONATE SODIUM ANTIMONYLGLUCONATE [MI]

Common Name

English

ANTIMONY SODIUM GLUCONATE (V)

Common Name

English

ANTIMONY SODIUM GLUCONATE SODIUM ANTIMONYLGLUCONATE

Common Name

English

SODIUM ANTIMONY (III) GLUCONATE

Common Name

English

TRIOSTIB

Common Name

English

Code System Code Type Description

EVMPD

SUB127002