U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C6H8O7.Na.Sb
Molecular Weight 336.8733
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM ANTIMONYLGLUCONATE

SMILES

C([C@]([H])([C@]([H])([C@@]([H])([C@]([H])(C(=O)[O-])O)[O-])[O-])[O-])O.[Na+].[Sb+3]

InChI

InChIKey=JEKOQEIHGHQVEI-ZBHRUSISSA-M
InChI=1S/C6H9O7.Na.Sb/c7-1-2(8)3(9)4(10)5(11)6(12)13;;/h2-5,7,11H,1H2,(H,12,13);;/q-3;+1;+3/p-1/t2-,3-,4+,5-;;/m1../s1

HIDE SMILES / InChI

Molecular Formula C6H8O7
Molecular Weight 192.1238
Charge -4
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Sb
Molecular Weight 121.7598
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Sodium antimonylgluconate (triostam) is a trivalent antimony compound. It was used for the treatment of schistosomiasis. Usually given intravenously.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q27778
Gene ID: NA
Gene Symbol: PFK
Target Organism: Schistosoma mansoni (Blood fluke)
200.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
TRIOSTAM

Approved Use

For the treatment of various types of a protozoal infection called leishmaniasis.
PubMed

PubMed

TitleDatePubMed
USE OF "TRIOSTAM" (SODIUM ANTIMONYLGLUCONATE) AGAINST RECTAL SCHISTOSOMIASIS IN TANGANYIKA.
1964 Mar
THE INTENSIVE TREATMENT OF RECTAL SCHISTOSOMIASIS WITH TRIOSTAM (SODIUM ANTIMONYLGLUCONATE).
1965 Jan
Stokes-Adams attacks following sodium antimonylgluconate (Triostam).
1966 Nov 19
Comparative trials of antimonial drugs in urinary schistosomiasis.
1968
Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.
1995 Jun 1
Patents

Sample Use Guides

The drug should be used at a total dosage not exceeding 25 mg. per kg. and a daily dosage not exceeding 6 mg. per kg.,
Route of Administration: Intravenous
In Vitro Use Guide
Both L. donovani trypanothione reductase and human erythrocyte glutathione reductase are inhibited by Sodium antimonylgluconate (5-100uM) in a timedependent manner.
Substance Class Chemical
Created
by admin
on Sat Jun 26 10:33:22 UTC 2021
Edited
by admin
on Sat Jun 26 10:33:22 UTC 2021
Record UNII
1U72RT57II
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM ANTIMONYLGLUCONATE
Common Name English
SODIUM SALT OF A TRIVALENT ANTIMONY DERIVATIVE OF GLUCONIC ACID
Common Name English
SODIUM ANTIMONY GLUCONATE
Common Name English
TRIOSTAM
Brand Name English
ANTIMONY SODIUM GLUCONATE SODIUM ANTIMONYLGLUCONATE [MI]
Common Name English
ANTIMONY SODIUM GLUCONATE (V)
Common Name English
ANTIMONY SODIUM GLUCONATE SODIUM ANTIMONYLGLUCONATE
MI  
Common Name English
SODIUM ANTIMONY (III) GLUCONATE
Common Name English
TRIOSTIB
Common Name English
Code System Code Type Description
EVMPD
SUB127002
Created by admin on Sat Jun 26 10:33:23 UTC 2021 , Edited by admin on Sat Jun 26 10:33:23 UTC 2021
PRIMARY
FDA UNII
1U72RT57II
Created by admin on Sat Jun 26 10:33:23 UTC 2021 , Edited by admin on Sat Jun 26 10:33:23 UTC 2021
PRIMARY
ChEMBL
CHEMBL2108095
Created by admin on Sat Jun 26 10:33:23 UTC 2021 , Edited by admin on Sat Jun 26 10:33:23 UTC 2021
PRIMARY
MERCK INDEX
M1962
Created by admin on Sat Jun 26 10:33:23 UTC 2021 , Edited by admin on Sat Jun 26 10:33:23 UTC 2021
PRIMARY Merck Index
ECHA (EC/EINECS)
235-699-3
Created by admin on Sat Jun 26 10:33:23 UTC 2021 , Edited by admin on Sat Jun 26 10:33:23 UTC 2021
PRIMARY
CAS
12550-17-3
Created by admin on Sat Jun 26 10:33:23 UTC 2021 , Edited by admin on Sat Jun 26 10:33:23 UTC 2021
PRIMARY
PUBCHEM
76968133
Created by admin on Sat Jun 26 10:33:23 UTC 2021 , Edited by admin on Sat Jun 26 10:33:23 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE