Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | 2C6H11O7.Ni |
| Molecular Weight | 448.9881 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Ni++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O
InChI
InChIKey=DVQYNXRSNFYQRW-IYEMJOQQSA-L
InChI=1S/2C6H12O7.Ni/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
| Molecular Formula | Ni |
| Molecular Weight | 58.6934 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H11O7 |
| Molecular Weight | 195.1473 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionSources: http://www.tera.org/ART/Nickel/Ni%20main%20text.PDFhttp://nj.gov/health/eoh/rtkweb/documents/fs/1342.pdfhttp://www.espimetals.com/index.php/676-msds/nickel-fluoride/692-nickel-fluoridehttp://nj.gov/health/eoh/rtkweb/documents/fs/1346.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27748567 | https://www.ncbi.nlm.nih.gov/pubmed/27824316http://www.tuks.nl/WFCProject/pdf/Electrodepositon_of_Nickel.pdfhttps://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C-10.pdfhttps://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdfCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8187719
Sources: http://www.tera.org/ART/Nickel/Ni%20main%20text.PDFhttp://nj.gov/health/eoh/rtkweb/documents/fs/1342.pdfhttp://www.espimetals.com/index.php/676-msds/nickel-fluoride/692-nickel-fluoridehttp://nj.gov/health/eoh/rtkweb/documents/fs/1346.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27748567 | https://www.ncbi.nlm.nih.gov/pubmed/27824316http://www.tuks.nl/WFCProject/pdf/Electrodepositon_of_Nickel.pdfhttps://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C-10.pdfhttps://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdf
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8187719
Nickel (II) oxide is an olive gray powder, insoluble in water and soluble in acids. It is produced industrially and used mainly as an intermediate in the production of nickel alloys and as a hydrogenation catalyst. Long-term inhalation of NiO is damaging to the lungs, causing lesions and in some cases cancer.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: map04064 |
|||
Target ID: GO:0044839 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | ECZEMOL Approved UseEczemol® is indicated for the treatment of moderate to severe eczema and atopic dermatitis. It has been found to work well with a variety of combination therapies. |
|||
PubMed
| Title | Date | PubMed |
|---|---|---|
| Differential Toxicities of Nickel Salts to the Nematode Caenorhabditis elegans. | 2016-08 |
|
| The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells. | 2016-07 |
|
| Involvement of L-type Ca²⁺ channel and toll-like receptor-4 in nickel-induced interleukin-8 gene expression. | 2016-01 |
|
| Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor. | 2015-03-01 |
|
| A not cytotoxic nickel concentration alters the expression of neuronal differentiation markers in NT2 cells. | 2015-03 |
|
| Substitution effects of a carbonated hydroxyapatite biomaterial against intoxication chloride nickel-exposed rats. | 2015-03 |
|
| Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury). | 2015-03 |
|
| Impact of cadmium, cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells. | 2015-01-02 |
|
| NiCl2-down-regulated antioxidant enzyme mRNA expression causes oxidative damage in the broiler(')s kidney. | 2014-12 |
|
| The effect of divalent metal cations on zinc uptake by mouse Zrt/Irt-like protein 1 (ZIP1). | 2014-09-15 |
|
| Detoxification of rats subjected to nickel chloride by a biomaterial-based carbonated orthophosphate. | 2014-09 |
|
| A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice. | 2014-05-01 |
|
| Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1. | 2014-04 |
|
| Nickel induces interleukin-1β secretion via the NLRP3-ASC-caspase-1 pathway. | 2014-04 |
|
| Genotoxic changes to rodent cells exposed in vitro to tungsten, nickel, cobalt and iron. | 2014-03-10 |
|
| Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish. | 2014-03-10 |
|
| MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells. | 2014-02-27 |
|
| Dietary nickel chloride induces oxidative stress, apoptosis and alters Bax/Bcl-2 and caspase-3 mRNA expression in the cecal tonsil of broilers. | 2014-01 |
|
| Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination. | 2014 |
|
| Crucial role of Toll-like receptors in the zinc/nickel-induced inflammatory response in vascular endothelial cells. | 2013-12-15 |
|
| Dietary nickel chloride restrains the development of small intestine in broilers. | 2013-11 |
|
| Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells. | 2013-09 |
|
| Disturbance of aerobic metabolism accompanies neurobehavioral changes induced by nickel in mice. | 2013-09 |
|
| p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells. | 2013-06-15 |
|
| Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators. | 2013-06 |
|
| L-tyrosinatonickel(II) complex: synthesis and structural, spectroscopic, magnetic, and biological properties of 2{[Ni(L-Tyr)2(bpy)]}·3H2O·CH3OH. | 2013-04-15 |
|
| Differential gene expression profile of the calanoid copepod, Pseudodiaptomus annandalei, in response to nickel exposure. | 2013-03 |
|
| Effect of Ni(II) on inflammatory gene expression in THP1 monocytic cells. | 2013-03 |
|
| Differentiation of skin sensitizers from irritant chemicals by interleukin-1α and macrophage inflammatory protein-2 in murine keratinocytes. | 2013-01-10 |
|
| Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma. | 2013 |
|
| GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression. | 2013 |
|
| Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. | 2012-07-20 |
|
| Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation. | 2012-07 |
|
| Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells. | 2012-04 |
|
| Co-exposure to nickel and cobalt chloride enhances cytotoxicity and oxidative stress in human lung epithelial cells. | 2012-02-01 |
|
| Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells. | 2011-12-09 |
|
| An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8. | 2011-12 |
|
| Nickel(II) induced JNK activation-regulated mitochondria-dependent apoptotic pathway leading to cultured rat pancreatic β-cell death. | 2011-11-18 |
|
| Activation of Akt/GSK3β and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells. | 2011-11 |
|
| Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line. | 2011 |
|
| Highly selective biaryl cross-coupling reactions between aryl halides and aryl Grignard reagents: a new catalyst combination of N-heterocyclic carbenes and iron, cobalt, and nickel fluorides. | 2009-08-26 |
|
| Effect of nickel and iron co-exposure on human lung cells. | 2004-04-15 |
|
| Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study. | 1999-05 |
|
| Daily intake of essential minerals and metallic micropollutants from foods in France. | 1998-06-30 |
|
| Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. | 1996-09 |
|
| How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? | 1996-09 |
|
| Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease. | 1991 |
|
| Occupational asthma from nickel sensitivity: II. Factors influencing the interaction of Ni2+, HSA, and serum antibodies with nickel related specificity. | 1984-02 |
|
| Carcinogenicity of nickel(II)hydroxides and nickel(II)sulfate in Wistar rats and its relation to the in vitro dissolution rates. | 1983 |
|
| NAS-benzidine reaction of blood cells-new simple peroxidase staining method using nickel-ammonium sulfate. | 1951-08 |
Patents
Sample Use Guides
Less than 0.1 mg Ni/day (<0.001 mg Ni/kg/day for a 70 kg adult).
Route of Administration:
Oral
The effect of 44 different metal salts on the activity of the reverse transcriptase
(RT) of the human immunodeficiency virus was investigated in vitro. For each metal compound, at least two concentrations were tested (10^-4 M and 10^-5 M). At 100 uM and 10 uM Ni2+ inhibited the RT activity on 5% and 11% of the control, respectively.
| Substance Class |
Chemical
Created
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2EQ06R5QSQ
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ACTIVE MOIETY |