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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C6H11O7.Ni
Molecular Weight 448.9885
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NICKEL GLUCONATE

SMILES

C([C@]([H])([C@]([H])([C@@]([H])([C@]([H])(C(=O)[O-])O)O)O)O)O.C([C@]([H])([C@]([H])([C@@]([H])([C@]([H])(C(=O)[O-])O)O)O)O)O.[Ni+2]

InChI

InChIKey=DVQYNXRSNFYQRW-IYEMJOQQSA-L
InChI=1S/2C6H12O7.Ni/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1

HIDE SMILES / InChI

Molecular Formula C6H11O7
Molecular Weight 195.1476
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Ni
Molecular Weight 58.6934
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

NICKEL AMMONIUM SULFATE is a "double salt" that is a weak oxidizing agent, giving an acidic solution when dissolved in water. It is used in electroplating. It is a toxic substance and inhalation causes irritation of nose and throat, ingestion causes vomiting, contact with eyes causes irritation so as contact with skin may cause dermatitis.

Originator

Curator's Comment:: Nickel was discovered by Axel Fredrik Cronstedt at 1751 in Sweden.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ECZEMOL

Approved Use

Eczemol® is indicated for the treatment of moderate to severe eczema and atopic dermatitis. It has been found to work well with a variety of combination therapies.
PubMed

PubMed

TitleDatePubMed
Carcinogenicity of nickel(II)hydroxides and nickel(II)sulfate in Wistar rats and its relation to the in vitro dissolution rates.
1983
Nickel oxide: potential carcinogenicity--a review and further evidence.
1984
Occupational asthma from nickel sensitivity: II. Factors influencing the interaction of Ni2+, HSA, and serum antibodies with nickel related specificity.
1984 Feb
Pulmonary deposition and clearance of a nickel oxide aerosol by inhalation.
1985 Feb
Carcinogenesis bioassays of nickel oxides and nickel-copper oxides by intramuscular administration to Fischer-344 rats.
1990 Oct
Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease.
1991
Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements.
1996 Sep
How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential?
1996 Sep
Daily intake of essential minerals and metallic micropollutants from foods in France.
1998 Jun 30
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.
1999 May
Effect of nickel and iron co-exposure on human lung cells.
2004 Apr 15
Molecular biology of nickel carcinogenesis: identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by specific insoluble nickel compounds.
2004 Jan
Effects of nickel, chromate, and arsenite on histone 3 lysine methylation.
2009 Apr 1
Nickel and binary metal mixture responses in Daphnia magna: molecular fingerprints and (sub)organismal effects.
2009 Apr 2
Highly selective biaryl cross-coupling reactions between aryl halides and aryl Grignard reagents: a new catalyst combination of N-heterocyclic carbenes and iron, cobalt, and nickel fluorides.
2009 Aug 26
The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2.
2009 Nov
A plasmacytoid dendritic cell (CD123+/CD11c-) based assay system to predict contact allergenicity of chemicals.
2009 Oct 1
Nickel(II)-induced oxidative stress, apoptosis, G2/M arrest, and genotoxicity in normal rat kidney cells.
2010
Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment.
2011 Apr 16
A novel DC therapy with manipulation of MKK6 gene on nickel allergy in mice.
2011 Apr 22
Nickel differentially regulates NFAT and NF-κB activation in T cell signaling.
2011 Aug 1
Effect of metals on β-actin and total protein synthesis in cultured human intestinal epithelial cells.
2011 Jan-Feb
Nickel promotes the invasive potential of human lung cancer cells via TLR4/MyD88 signaling.
2011 Jul 11
Nickel-induced down-regulation of ΔNp63 and its role in the proliferation of keratinocytes.
2011 Jun 15
Nodal-mediated epigenesis requires dynamin-mediated endocytosis.
2011 Mar
In vitro evaluation of the toxicity induced by nickel soluble and particulate forms in human airway epithelial cells.
2011 Mar
Effects of nickel treatment on H3K4 trimethylation and gene expression.
2011 Mar 24
L-carnitine protects against nickel-induced neurotoxicity by maintaining mitochondrial function in Neuro-2a cells.
2011 May 15
Activation of Akt/GSK3β and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells.
2011 Nov
Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles.
2011 Nov
Nickel exposure induces oxidative damage to mitochondrial DNA in Neuro2a cells: the neuroprotective roles of melatonin.
2011 Nov
Nickel(II) induced JNK activation-regulated mitochondria-dependent apoptotic pathway leading to cultured rat pancreatic β-cell death.
2011 Nov 18
Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation.
2012 Jul
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.
2012 Jul 20
Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma.
2013
GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression.
2013
L-tyrosinatonickel(II) complex: synthesis and structural, spectroscopic, magnetic, and biological properties of 2{[Ni(L-Tyr)2(bpy)]}·3H2O·CH3OH.
2013 Apr 15
Crucial role of Toll-like receptors in the zinc/nickel-induced inflammatory response in vascular endothelial cells.
2013 Dec 15
Differentiation of skin sensitizers from irritant chemicals by interleukin-1α and macrophage inflammatory protein-2 in murine keratinocytes.
2013 Jan 10
Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators.
2013 Jun
p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells.
2013 Jun 15
Differential gene expression profile of the calanoid copepod, Pseudodiaptomus annandalei, in response to nickel exposure.
2013 Mar
Effect of Ni(II) on inflammatory gene expression in THP1 monocytic cells.
2013 Mar
The toxic effects of nickel chloride on liver, erythropoiesis, and development in Wistar albino preimplanted rats can be reversed with selenium pretreatment.
2013 May
Dietary nickel chloride restrains the development of small intestine in broilers.
2013 Nov
Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells.
2013 Sep
Disturbance of aerobic metabolism accompanies neurobehavioral changes induced by nickel in mice.
2013 Sep
NiCl2-down-regulated antioxidant enzyme mRNA expression causes oxidative damage in the broiler(')s kidney.
2014 Dec
The effect of divalent metal cations on zinc uptake by mouse Zrt/Irt-like protein 1 (ZIP1).
2014 Sep 15
Differential Toxicities of Nickel Salts to the Nematode Caenorhabditis elegans.
2016 Aug
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 13:53:49 UTC 2021
Edited
by admin
on Sat Jun 26 13:53:49 UTC 2021
Record UNII
2EQ06R5QSQ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NICKEL GLUCONATE
INCI   WHO-DD  
INCI  
Official Name English
NICKEL(2+) GLUCONATE
Common Name English
NICKEL, BIS(D-GLUCONATO-O1,O2)-
Common Name English
NICKEL GLUCONATE [WHO-DD]
Common Name English
NICKEL GLUCONATE [INCI]
Common Name English
NICCOLUM GLUCONICUM
Common Name English
NICKEL, BIS(D-GLUCONATO-.KAPPA.O1,.KAPPA.O2)-
Common Name English
Code System Code Type Description
PUBCHEM
71587260
Created by admin on Sat Jun 26 13:53:49 UTC 2021 , Edited by admin on Sat Jun 26 13:53:49 UTC 2021
PRIMARY
FDA UNII
2EQ06R5QSQ
Created by admin on Sat Jun 26 13:53:49 UTC 2021 , Edited by admin on Sat Jun 26 13:53:49 UTC 2021
PRIMARY
EPA CompTox
71957-07-8
Created by admin on Sat Jun 26 13:53:49 UTC 2021 , Edited by admin on Sat Jun 26 13:53:49 UTC 2021
PRIMARY
RXCUI
1368209
Created by admin on Sat Jun 26 13:53:49 UTC 2021 , Edited by admin on Sat Jun 26 13:53:49 UTC 2021
PRIMARY RxNorm
CAS
71957-07-8
Created by admin on Sat Jun 26 13:53:49 UTC 2021 , Edited by admin on Sat Jun 26 13:53:49 UTC 2021
PRIMARY
EVMPD
SUB47317
Created by admin on Sat Jun 26 13:53:49 UTC 2021 , Edited by admin on Sat Jun 26 13:53:49 UTC 2021
PRIMARY
ECHA (EC/EINECS)
276-205-6
Created by admin on Sat Jun 26 13:53:49 UTC 2021 , Edited by admin on Sat Jun 26 13:53:49 UTC 2021
PRIMARY
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PARENT -> SALT/SOLVATE
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ACTIVE MOIETY