U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 11:33:49 GMT 2023
Edited
by admin
on Sat Dec 16 11:33:49 GMT 2023
Protein Type RECEPTOR
Protein Sub Type GROWTH FACTOR RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
RO03J093CP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EPIDERMAL GROWTH FACTOR RECEPTOR
Common Name English
ERBB
Common Name English
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1
Common Name English
EGFR
Common Name English
HER1
Common Name English
HER-1
Common Name English
PROTO-ONCOGENE C-ERBB-1
Common Name English
Code System Code Type Description
FDA UNII
RO03J093CP
Created by admin on Sat Dec 16 11:33:52 GMT 2023 , Edited by admin on Sat Dec 16 11:33:52 GMT 2023
PRIMARY
UNIPROT
P00533
Created by admin on Sat Dec 16 11:33:52 GMT 2023 , Edited by admin on Sat Dec 16 11:33:52 GMT 2023
PRIMARY
From To
1_7 1_34
1_133 1_163
1_166 1_175
1_170 1_183
1_191 1_199
1_195 1_207
1_208 1_216
1_212 1_224
1_227 1_236
1_240 1_267
1_271 1_283
1_287 1_302
1_305 1_309
1_313 1_338
1_446 1_475
1_482 1_491
1_486 1_499
1_502 1_511
1_515 1_531
1_534 1_547
1_538 1_555
1_558 1_567
1_571 1_593
1_596 1_604
1_600 1_612
Glycosylation Link Type Site
N 1_32
N 1_49
N 1_104
N 1_151
N 1_172
N 1_328
N 1_337
N 1_389
N 1_420
N 1_504
N 1_544
N 1_579
N 1_599
Related Record Type Details
ZIRCONIUM PANITUMUMAB ZR-89
RADIOLIGAND->TARGET
Structure of (3R,4R)-4-AMINO-1-((4-((3-METHOXYPHENYL)AMINO)PYRROLO(2,1-F)(1,2,4)TRIAZIN-5-YL)METHYL)-3-PIPERIDINYL .BETA.-D-GLUCOPYRANOSIDURONIC ACID
INHIBITOR -> TARGET
IC50
CETUXIMAB
INHIBITOR -> TARGET
Structure of WHI-P 154
INHIBITOR -> TARGET
IZALONTAMAB
INHIBITOR -> TARGET
LAPRITUXIMAB EMTANSINE
INHIBITOR -> TARGET
Structure of NERATINIB DIMETHYLAMINE N-OXIDE
INHIBITOR -> TARGET
Structure of ABIVERTINIB
INHIBITOR -> TARGET
FUTUXIMAB
INHIBITOR -> TARGET
TOMUZOTUXIMAB
INHIBITOR -> TARGET
DULIGOTUZUMAB
INHIBITOR -> TARGET
Structure of CANERTINIB
INHIBITOR -> TARGET
ALLOGENEIC HUMAN AMNION/CHORION MEMBRANE
PARENT -> CONSTITUENT ALWAYS PRESENT
Structure of NRC-2694
INHIBITOR -> TARGET
In an in vitro study to test kinase selectivity profile of NRC-2694 (free base) against a panel of 353 kinases, NRC-2694 was found to be effective (0 or 0.1% of DMSO control) against EGFR, EGFR (E746-A750del), EGFR (G719C), EGFR (G719S), EGFR (L747-E749del, A750P), EGFR (L747-S752del, P753S), EGFR (L747-T751del, Sins), EGFR (L858R), EGFR (L861Q), EGFR (S752-I759del), GAK and LOK kinase.
IN-VITRO
AVID-100
CONJUGATED TOXIN->TARGET
Structure of N-DESMETHYL NERATINIB
INHIBITOR -> TARGET
AMIVANTAMAB
INHIBITOR -> TARGET
SERCLUTAMAB
LIGAND->TARGET
Structure of 4,6-QUINAZOLINEDIAMINE, N4-(3-CHLORO-4-((3-FLUOROPHENYL)METHOXY)PHENYL)-
INHIBITOR -> TARGET
IC50
Structure of ZORIFERTINIB
INHIBITOR -> TARGET
IC50
Structure of SPH-5030
INHIBITOR->OFF-TARGET
IC50
SERCLUTAMAB TALIRINE
CONJUGATED TOXIN->TARGET
Structure of IBRUTINIB
INHIBITOR->OFF-TARGET
IC50
Structure of DOSIMERTINIB
INHIBITOR -> TARGET
IC50
Structure of AFATINIB
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
Structure of VARLITINIB
INHIBITOR -> TARGET
Structure of NERATINIB
INHIBITOR -> TARGET
BAFISONTAMAB
INHIBITOR -> TARGET
DEPATUXIZUMAB MAFODOTIN
LIGAND->TARGET
Structure of ERLOTINIB
INHIBITOR -> TARGET
MODOTUXIMAB
INHIBITOR -> TARGET
LAPRITUXIMAB
INHIBITOR -> TARGET
NIMOTUZUMAB
INHIBITOR -> TARGET
PANITUMUMAB
INHIBITOR -> TARGET
AVID-100
INHIBITOR -> TARGET
Izalontamab Brengitecan
INHIBITOR -> TARGET
Structure of Tigozertinib
WEAK INHIBITOR->TARGET
IC50
ABT-806I
INHIBITOR -> TARGET
Structure of Oritinib
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
Structure of (3R,4R)-4-AMINO-1-((4-((4-HYDROXY-3-METHOXYPHENYL)AMINO)PYRROLO(2,1-F)(1,2,4)TRIAZIN-5-YL)METHYL)-3-PIPERIDINOL
INHIBITOR -> TARGET
IC50
Structure of DACOMITINIB ANHYDROUS
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
Structure of XILIERTINIB
INHIBITOR -> TARGET
IC50
ANTI-EGFR MONOCLONAL ANTIBODY MIXTURE MM-151 ANTIBODY COMPONENT 3
INHIBITOR -> TARGET
LOSATUXIZUMAB VEDOTIN
CONJUGATED TOXIN->TARGET
DEPATUXIZUMAB
INHIBITOR -> TARGET
Structure of 2-PROPENAMIDE, N-(4-((3-CHLORO-4-HYDROXYPHENYL)AMINO)-6-QUINAZOLINYL)-
INHIBITOR -> TARGET
IC50
Structure of PYROTINIB
INHIBITOR -> TARGET
IC50
Structure of SAPITINIB
INHIBITOR -> TARGET
Structure of AEE-788
INHIBITOR -> TARGET
Structure of BEFOTERTINIB
INHIBITOR -> TARGET
QRH-882260
LIGAND->TARGET
Structure of FALNIDAMOL
INHIBITOR -> TARGET
MRG-003
CONJUGATED TOXIN->TARGET
Structure of BMS-690514
INHIBITOR -> TARGET
IC50
CETUXIMAB SAROTALOCAN
LIGAND->TARGET
IMAGING AGENT
DEPATUXIZUMAB MAFODOTIN
INHIBITOR -> TARGET
Structure of AV-412 FREE BASE
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
Structure of EPITINIB
INHIBITOR -> TARGET
NECITUMUMAB
INHIBITOR -> TARGET
Becotatug
INHIBITOR -> TARGET
Structure of POZIOTINIB
INHIBITOR -> TARGET
MATUZUMAB
INHIBITOR -> TARGET
ZALUTUMUMAB
INHIBITOR -> TARGET
Structure of VANDETANIB
INHIBITOR -> TARGET
ABT-806I
RADIOLIGAND->TARGET
Structure of GEFITINIB
INHIBITOR -> TARGET
Structure of ALLITINIB
INHIBITOR -> TARGET
irreversible selective inhibitor
IRREVERSIBLE INHIBITOR
IC50
Structure of NEPTINIB
INHIBITOR -> TARGET
DEMUPITAMAB
INHIBITOR -> TARGET
Structure of LAPATINIB
INHIBITOR -> TARGET
Structure of NERATINIB PYRIDINE N-OXIDE
INHIBITOR -> TARGET
Structure of N-(4-((3-CHLORO-4-((3-FLUOROPHENYL)METHOXY)PHENYL)AMINO)-6-QUINAZOLINYL)-2,3-DIHYDROXYPROPANAMIDE
INHIBITOR -> TARGET
IC50
TAK-186 activated dimer
INHIBITOR -> TARGET
Kills egfr expressing cells in tumor micfro
Structure of PKI-166
INHIBITOR -> TARGET
Structure of PELITINIB
INHIBITOR -> TARGET
Pamvatamig
INHIBITOR -> TARGET
IN-VIVO
LOSATUXIZUMAB
LIGAND->TARGET
ETEVRITAMAB
LIGAND->TARGET
Structure of BRIGATINIB
INHIBITOR -> TARGET
INHIBITOR
IC50
Structure of SUTETINIB
INHIBITOR -> TARGET
IN-VITRO
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
NCATS
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