U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:33:49 GMT 2023
Edited
by admin
on Sat Dec 16 11:33:49 GMT 2023
Protein Type RECEPTOR
Protein Sub Type GROWTH FACTOR RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
RO03J093CP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EPIDERMAL GROWTH FACTOR RECEPTOR
Common Name English
ERBB
Common Name English
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1
Common Name English
EGFR
Common Name English
HER1
Common Name English
HER-1
Common Name English
PROTO-ONCOGENE C-ERBB-1
Common Name English
Code System Code Type Description
FDA UNII
RO03J093CP
Created by admin on Sat Dec 16 11:33:52 GMT 2023 , Edited by admin on Sat Dec 16 11:33:52 GMT 2023
PRIMARY
UNIPROT
P00533
Created by admin on Sat Dec 16 11:33:52 GMT 2023 , Edited by admin on Sat Dec 16 11:33:52 GMT 2023
PRIMARY
From To
1_7 1_34
1_133 1_163
1_166 1_175
1_170 1_183
1_191 1_199
1_195 1_207
1_208 1_216
1_212 1_224
1_227 1_236
1_240 1_267
1_271 1_283
1_287 1_302
1_305 1_309
1_313 1_338
1_446 1_475
1_482 1_491
1_486 1_499
1_502 1_511
1_515 1_531
1_534 1_547
1_538 1_555
1_558 1_567
1_571 1_593
1_596 1_604
1_600 1_612
Glycosylation Link Type Site
N 1_32
N 1_49
N 1_104
N 1_151
N 1_172
N 1_328
N 1_337
N 1_389
N 1_420
N 1_504
N 1_544
N 1_579
N 1_599
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INHIBITOR -> TARGET
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INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
PARENT -> CONSTITUENT ALWAYS PRESENT
INHIBITOR -> TARGET
In an in vitro study to test kinase selectivity profile of NRC-2694 (free base) against a panel of 353 kinases, NRC-2694 was found to be effective (0 or 0.1% of DMSO control) against EGFR, EGFR (E746-A750del), EGFR (G719C), EGFR (G719S), EGFR (L747-E749del, A750P), EGFR (L747-S752del, P753S), EGFR (L747-T751del, Sins), EGFR (L858R), EGFR (L861Q), EGFR (S752-I759del), GAK and LOK kinase.
IN-VITRO
CONJUGATED TOXIN->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR->OFF-TARGET
IC50
CONJUGATED TOXIN->TARGET
INHIBITOR->OFF-TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
WEAK INHIBITOR->TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
CONJUGATED TOXIN->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
CONJUGATED TOXIN->TARGET
INHIBITOR -> TARGET
IC50
LIGAND->TARGET
IMAGING AGENT
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
irreversible selective inhibitor
IRREVERSIBLE INHIBITOR
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
Kills egfr expressing cells in tumor micfro
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IN-VIVO
LIGAND->TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
INHIBITOR
IC50
INHIBITOR -> TARGET
IN-VITRO
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL