U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C30H35N7O2
Molecular Weight 525.6446
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AUMOLERTINIB

SMILES

COC1=CC(N(C)CCN(C)C)=C(NC(=O)C=C)C=C1NC2=NC(=CC=N2)C3=CN(C4CC4)C5=C3C=CC=C5

InChI

InChIKey=DOEOECWDNSEFDN-UHFFFAOYSA-N
InChI=1S/C30H35N7O2/c1-6-29(38)32-24-17-25(28(39-5)18-27(24)36(4)16-15-35(2)3)34-30-31-14-13-23(33-30)22-19-37(20-11-12-20)26-10-8-7-9-21(22)26/h6-10,13-14,17-20H,1,11-12,15-16H2,2-5H3,(H,32,38)(H,31,33,34)

HIDE SMILES / InChI

Molecular Formula C30H35N7O2
Molecular Weight 525.6446
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Thu Jul 06 09:02:33 UTC 2023
Edited
by admin
on Thu Jul 06 09:02:33 UTC 2023
Record UNII
T4RS462G19
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AUMOLERTINIB
USAN   INN  
Official Name English
HS-10296
Code English
EQ-143
Code English
ALMONERTINIB
Common Name English
N-(5-((4-(1-CYCLOPROPYL-1H-INDOL-3-YL)PYRIMIDIN-2-YL)AMINO)-2-((2-(DIMETHYLAMINO)ETHYL)(METHYL)AMINO)-4-METHOXYPHENYL)ACRYLAMIDE
Systematic Name English
aumolertinib [INN]
Common Name English
2-PROPENAMIDE, N-(5-((4-(1-CYCLOPROPYL-1H-INDOL-3-YL)-2-PYRIMIDINYL)AMINO)-2-((2-(DIMETHYLAMINO)ETHYL)METHYLAMINO)-4-METHOXYPHENYL)-
Systematic Name English
AUMOLERTINIB [USAN]
Common Name English
EQ143
Code English
EGFR T790M INHIBITOR HS-10296
Common Name English
Aumolertinib [WHO-DD]
Common Name English
Code System Code Type Description
FDA UNII
T4RS462G19
Created by admin on Thu Jul 06 09:02:33 UTC 2023 , Edited by admin on Thu Jul 06 09:02:33 UTC 2023
PRIMARY
CAS
1899921-05-1
Created by admin on Thu Jul 06 09:02:33 UTC 2023 , Edited by admin on Thu Jul 06 09:02:33 UTC 2023
PRIMARY
SMS_ID
300000032232
Created by admin on Thu Jul 06 09:02:33 UTC 2023 , Edited by admin on Thu Jul 06 09:02:33 UTC 2023
PRIMARY
USAN
JK-232
Created by admin on Thu Jul 06 09:02:33 UTC 2023 , Edited by admin on Thu Jul 06 09:02:33 UTC 2023
PRIMARY
INN
11295
Created by admin on Thu Jul 06 09:02:33 UTC 2023 , Edited by admin on Thu Jul 06 09:02:33 UTC 2023
PRIMARY INN
PUBCHEM
121280087
Created by admin on Thu Jul 06 09:02:33 UTC 2023 , Edited by admin on Thu Jul 06 09:02:33 UTC 2023
PRIMARY
NCI_THESAURUS
C133691
Created by admin on Thu Jul 06 09:02:33 UTC 2023 , Edited by admin on Thu Jul 06 09:02:33 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
IRREVERSIBLE INHIBITOR
Related Record Type Details
ACTIVE MOIETY