Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H26N4O3 |
| Molecular Weight | 418.4882 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=NC=NC(NC3=CC=CC(=C3)C#C)=C2C=C1OCCCN4CCOCC4
InChI
InChIKey=WBKHQQZRHCECKK-UHFFFAOYSA-N
InChI=1S/C24H26N4O3/c1-3-18-6-4-7-19(14-18)27-24-20-15-23(22(29-2)16-21(20)25-17-26-24)31-11-5-8-28-9-12-30-13-10-28/h1,4,6-7,14-17H,5,8-13H2,2H3,(H,25,26,27)
| Molecular Formula | C24H26N4O3 |
| Molecular Weight | 418.4882 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:44:36 UTC 2023
by
admin
on
Sat Dec 16 09:44:36 UTC 2023
|
| Record UNII |
O898S9836V
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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Common Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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16129168
Created by
admin on Sat Dec 16 09:44:36 UTC 2023 , Edited by admin on Sat Dec 16 09:44:36 UTC 2023
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936446-61-6
Created by
admin on Sat Dec 16 09:44:36 UTC 2023 , Edited by admin on Sat Dec 16 09:44:36 UTC 2023
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O898S9836V
Created by
admin on Sat Dec 16 09:44:36 UTC 2023 , Edited by admin on Sat Dec 16 09:44:36 UTC 2023
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C187045
Created by
admin on Sat Dec 16 09:44:36 UTC 2023 , Edited by admin on Sat Dec 16 09:44:36 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> INHIBITOR |
In an in vitro study to test kinase selectivity profile of NRC-2694 (free base) against a panel of 353 kinases, NRC-2694 was found to be effective (0 or 0.1% of DMSO control) against EGFR, EGFR (E746-A750del), EGFR (G719C), EGFR (G719S), EGFR (L747-E749del, A750P), EGFR (L747-S752del, P753S), EGFR (L747-T751del, Sins), EGFR (L858R), EGFR (L861Q), EGFR (S752-I759del), GAK and LOK kinase.
IN-VITRO
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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