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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 08:06:13 GMT 2025
Edited
by admin
on Wed Apr 02 08:06:13 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
981YA69AO3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
JMT-101
Preferred Name English
Becotatug
INN  
Official Name English
Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-Mus musculus monoclonal JMT101 ?1-chain), disulfide with human-Mus musculus monoclonal JMT101 ?-chain, dimer
Common Name English
becotatug [INN]
Common Name English
JMT101
Code English
gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV4-4*08 (79.4%)-(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*03, G1m3, nG1m1 (CH1R120 (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12
Common Name English
immunoglobulin G1-kappa, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)], humanized monoclonal antibody
Common Name English
JMT 101 [WHO-DD]
Common Name English
JMT101 (FULLY HUMAN MONOCLONAL IGG1 ANTIBODY TARGETING EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR))
Common Name English
Code System Code Type Description
NCI_THESAURUS
C178313
Created by admin on Wed Apr 02 08:06:13 GMT 2025 , Edited by admin on Wed Apr 02 08:06:13 GMT 2025
PRIMARY
SMS_ID
300000046876
Created by admin on Wed Apr 02 08:06:13 GMT 2025 , Edited by admin on Wed Apr 02 08:06:13 GMT 2025
PRIMARY
FDA UNII
981YA69AO3
Created by admin on Wed Apr 02 08:06:13 GMT 2025 , Edited by admin on Wed Apr 02 08:06:13 GMT 2025
PRIMARY
CAS
2648260-93-7
Created by admin on Wed Apr 02 08:06:13 GMT 2025 , Edited by admin on Wed Apr 02 08:06:13 GMT 2025
PRIMARY
INN
12391
Created by admin on Wed Apr 02 08:06:13 GMT 2025 , Edited by admin on Wed Apr 02 08:06:13 GMT 2025
PRIMARY
From To
1_22 1_95
2_22 2_95
2_146 2_202
2_222 4_214
2_263 2_323
1_146 1_202
2_369 2_427
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_222 3_214
1_228 2_228
1_231 2_231
1_263 1_323
1_369 1_427
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_299
N 2_299
Related Record Type Details
Becotatug Vedotin
CONJUGATE->CONJUGATE COMPONENT
EPIDERMAL GROWTH FACTOR RECEPTOR
TARGET -> INHIBITOR
Related Record Type Details
Becotatug
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] C-TERMINUS PIDOLIC ACID SZB83O1W42
AMINO ACID REMOVAL [1_449] [2_449] N-TERMINUS LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
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